PDA

View Full Version : NYC Bone Seminar 10/24; "Trabecular bone formation by mechanicaland PTH stimulation"



Steve Cowin
10-21-2001, 05:22 AM
To Bone Researchers in the NYC area:
The NYC mineralized tissue seminar begins its new millennium
series on Wednesday night this week, October 24th. The speaker is X.
Edward Guo, Ph.D., Associate Professor of Biomedical Engineering,
Director of Bone Bioengineering Laboratory, Department of Biomedical
Engineering, Columbia University, New York. He will speak on
TRABECULAR BONE FORMATION BY MECHANICAL AND PTH STIMULATION. An
abstract of this talk and a description of his research interests are
given below. The same information on the other fall seminar speakers
is posted on www.bonenet.net and will be circulated as the date of
each seminar approaches.

Speaker: X. Edward Guo, Ph.D., Associate Professor of Biomedical
Engineering, Director of Bone Bioengineering Laboratory, Department
of Biomedical Engineering, Columbia University, New York

Title: TRABECULAR BONE FORMATION BY MECHANICAL AND PTH STIMULATION

Abstract: Trabecular bone adapts in response to its mechanical
environment. A quantitative characterization of the relationship
between trabecular bone adaptation and mechanical loading is
important in the understanding of the etiology of age-related bone
fractures, optimal design of total joint replacements, and bone loss
due to microgravity. In addition, trabecular bone responds to
changes in its hormonal factors such as parathyroid hormone (PTH),
which is an important factor that mediates bone response to
mechanical stimuli. In this study, the effect of PTH on trabecular
bone adaptation to mechanical load was investigated using an in vivo
rat tail vertebra model.
Both PTH and mechanical loading stimulate bone formation in
trabecular bone through the increase in MAR. These results
demonstrate the synergistic interaction between PTH and mechanical
stimuli. Furthermore, the results suggest that this synergetic
effect of PTH on trabecular bone adaptation by mechanical loading is
mostly through the recruitment of osteoblasts. For the first time, a
direct correlation between bone formation activities and local
mechanical parameters in trabecular bone tissue has been established.

RESEARCH INTERESTS OF X. EDWARD GUO: Major research efforts in bone
biomechanics, with emphasis on understanding the cellular/molecular
mechanisms of bone response to mechanical and hormone stimulation
using both in vivo and in vitro models; computational modeling of
bone microstructure and constitutive modeling of biological tissues.

NOTE: PRIOR TO ED GUO'S SEMINAR THERE WILL BE A PRESENTATION TO
PROFESSOR ALBERT HIRSCHMAN OF SUNY DOWNSTATE MEDICAL CENTER
(RETIRED). THE PURPOSE IS TO EXPRESS OUR APPRECIATION TO AL FOR HIS
COMMITMENT TO THE PUBLIC SEMINAR SERIES ON MINERALIZED TISSUE
RESEARCH (THE BONE AND TOOTH CLUB) FOR OVER THIRTY YEARS.

WHERE AND WHEN: The seminar series is to be held this Fall in room
3309 at the City University of New York (CUNY) Graduate Center (GC)
on Wednesdays from 7 to 8:30 PM. A space is available for socializing
before the seminar. The paragraphs below detail the location of the
seminar room and the socializing area.

TRAVEL TO THE CITY UNIVERSITY OF NEW YORK (CUNY) GRADUATE CENTER (GC)

The Graduate Center (GC) of the City University of New York
(CUNY) is located in the newly renovated Altman Building at 365 5th
Avenue. The Altman Building occupies a city block bounded by 35th and
34th street on the north and south, respectively, and by Madison
Avenue and 5th Avenue and on the east and west, respectively. The
Altman Building is catty-corner from the Empire State Building. The
GC shares this building with the Science Division of the New York
Public Library and Oxford University Press. The entrance to the GC is
on 5th Avenue between, and almost equidistant from, East 34th Street
and East 35th Street.

The Pennsylvania Station (Amtrak, LLRR and New Jersey
Transit) is between 31st street and 33rd street on 7th Avenue. Grand
Central Station (Metro North) is on 42nd Street at Park Avenue. Park
Avenue is two blocks east of 5th Avenue (Madison is in between). Both
of these main line stations are short walks from the GC. The PATH
trains to New Jersey have a station at 34th Street and 6th Avenue.
For the well to do and important, there is a heliport at 34th Street
and East river, 6 avenue blocks to the east.

Almost all the Manhattan subway lines have a station on 34th
Street and within several avenue blocks of the GC. There are a number
of bus lines that run on 34th street and on 5th Avenue. There are a
number of parking garages around the GC. There is money to support
parking for interested students, apply to Steve Cowin
(scccc@cunyvm.cuny,edu).

THE LOCATION OF THE BONE SEMINAR ACTIVITIES WITHIN THE GRADUATE CENTER (GC)

When you enter the GC from 5th Avenue there is a reception
counter in the center of a reception room and the elevators are
straight ahead. Before you are allowed to walk down the hall to the
bank of elevators you must identify yourself to the security people.
This can be done with a CUNY ID or a picture ID (and your signature
in a guest book). There are two possible locations you might be
interested in going for the seminar activities: the first is the
seminar room on the 3rd floor (#3309) and the second is the dining
commons on the 8th floor to visit with people before the seminar. If
it is near the seminar start time of 7 PM you should proceed directly
to 3309 on the 3rd floor. When you get off the elevator on the 3rd
floor you head east, then north, then east again to arrive at room
3309. If you arrive at the GC with a few minutes to spare you should
come up the 8th floor dining commons to socialize with the other
seminar attendees and the evening's speaker. When you get off the
elevator on the 8th floor you head east, then north (or south), then
turn east into the marked dining commons.

If you are heading for the dining commons you may want to
consider visiting the 365 Express on the 1st floor for sandwiches,
snacks and drinks (open to 7 PM). The dining commons is a large room
with a skylight on the 8th floor; it has tables and chairs for
dining, but it has no food service when the adjacent cafeteria is not
open (it closes at 3PM). Therefore if you would like a sandwich,
snack or drink (including juices, sodas, beer and some other
alcoholic drinks) when you are visiting with people in the dining
commons on the 8th floor before a seminar, you may want to consider
purchasing them at the 365 Express on the first floor before you get
on the elevator and take them with you up to the dining commons on
the 8th floor. The 365 Express is directly off the GC reception room
(where you entered) on the 1st floor, off the southeast corner of the
room.

CLOSING NOTES

Future seminars are posted on www.bonenet.net, a website dedicated to
research on the mechanosensory system in bone. (This website is
operational, but not fully developed and suggestions for further
development of the site would be appreciated.) You may request a
reminder for each seminar by sending an email to Steve Cowin
(scccc@cunyvm.cuny.edu).

We hope that this seminar series will appeal to you. We will welcome
your attendance and hope that you will pass along this information to
interested colleagues. Please direct your questions, requests for
more information and feedback to me.

Kind regards Steve Cowin
--

************************************
Phone (212) 799-7970 (Office at Home)
Fax (212) 799-7970 (Office at Home)
Please note that my old fax number at home [(212) 787-3757] is no
longer active.
Phone (212) 650-5208 (Work)
Email


IMPORTANT, PLEASE NOTE
NEW (2001) PREFERRED MAILING ADDRESS
Stephen C. Cowin
2166 Broadway
Apartment 12D
New York, NY 10024

The phone number and zip code are unchanged.

WORK ADDRESS:
Stephen C. Cowin
Director, New York Center for Biomedical Engineering
School of Engineering
The City College
138th Street and Convent Avenue
New York, NY 10031-9198, U. S. A.
*************************************

---------------------------------------------------------------
To unsubscribe send SIGNOFF BIOMCH-L to LISTSERV@nic.surfnet.nl
For information and archives: http://isb.ri.ccf.org/biomch-l
---------------------------------------------------------------