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Steve Cowin
11-22-2001, 12:01 PM
To Bone Researchers in the NYC area:
The NYC mineralized tissue seminar will have its third
seminar in its new millennium series on Wednesday night this week
November 28th. The speaker is Nancy P. Camacho, PhD., Associate
Scientist, Mineralized Tissue Section, Research Division, Hospital
for Special Surgery, New York, NY and Visiting Assistant Professor of
Biomedical Engineering, The City College of the City University of
New York. She will speak on BISPHOSPHONATES IN OSTEOGENESIS
IMPERFECTA: ARE WE MAKING BRITTLE BONES MORE BRITTLE? An abstract of
this talk and a description of her research interests are given
below. The same information on the other fall seminar speakers is
posted on www.bonenet.net and will be circulated as the date of each
seminar approaches.

Speaker: Nancy P. Camacho, PhD., Associate Scientist, Mineralized
Tissue Section, Research Division, Hospital for Special Surgery, New
York, NY

Title: BISPHOSPHONATES IN OSTEOGENESIS IMPERFECTA: ARE WE MAKING
BRITTLE BONES MORE BRITTLE?


Abstract: Recently, bisphosphonates have been proposed as a therapy
for children with Osteogenesis Imperfecta (OI), a heritable disease
characterized by brittle bones and multiple fractures. There have
also been recent reports of potential negative effects of
bisphosphonates on bone quality, namely increased microdamage and
brittleness. In our current studies, we are investigating the effects
of alendronate on bone quality in an animal model of OI, the oim/oim
mouse. Femoral three-point bend biomechanical tests combined with
geometric analysis, infrared imaging and quantitative backscattered
electron imaging (qBEI) measurements of tissue density have been
carried out to determine material properties of cortical and
metaphyseal bone in growing oim/oim and wildtype (+/+) mice treated
with alendronate for short term studies (8 week period), and long
term studies (24 weeks). In addition, we have investigated the
effects of alendronate when given intermittently versus continuously.
The results of these studies support the theory that alendronate
treatment is effective in reducing fractures in OI, that continuous
treatment is more effective than intermittent, and that increased
tissue mineral density is an important determinant of brittleness in
both non-treated oim/oim and alendronate-treated wildtype mice bone.
Further insights into the effects of bisphosphonates on bone
properties will aid in the determination of the best approach for
treatment of children such that bone strength and bone quality are
maximized.

RESEARCH INTERESTS OF NANCY CAMACHO: Ultrastructure and mechanical
behavior of bone and cartilage; Spectroscopic imaging of mineral and
matrix organization in connective tissues; Mineralization
abnormalities in bone disease; Osteogenesis Imperfecta; Pathologic
calcification; Effect of therapeutics on fracture healing.

WHERE AND WHEN: The seminar series is to be held this Fall in room
3309 at the City University of New York (CUNY) Graduate Center (GC)
on Wednesdays from 7 to 8:30 PM. There will be some socializing
before the seminar in the GC snack bar on the first floor, besides
the usual snacks and drinks the 365 Express also carries beer and
some other alcoholic beverages.

TRAVEL TO THE CITY UNIVERSITY OF NEW YORK (CUNY) GRADUATE CENTER (GC)

The Graduate Center (GC) of the City University of New York
(CUNY) is located in the newly renovated Altman Building at 365 5th
Avenue. The Altman Building occupies a city block bounded by 35th and
34th street on the north and south, respectively, and by Madison
Avenue and 5th Avenue and on the east and west, respectively. The
Altman Building is catty-corner from the Empire State Building. The
GC shares this building with the Science Division of the New York
Public Library and Oxford University Press. The entrance to the GC is
on 5th Avenue between, and almost equidistant from, East 34th Street
and East 35th Street.

The Pennsylvania Station (Amtrak, LLRR and New Jersey
Transit) is between 31st street and 33rd street on 7th Avenue. Grand
Central Station (Metro North) is on 42nd Street at Park Avenue. Park
Avenue is two blocks east of 5th Avenue (Madison is in between). Both
of these main line stations are short walks from the GC. The PATH
trains to New Jersey have a station at 34th Street and 6th Avenue.
There is also a heliport at 34th Street and East river, 6 avenue
blocks to the east.

Almost all the Manhattan subway lines have a station on 34th
Street and within several avenue blocks of the GC. There are a number
of bus lines that run on 34th street and on 5th Avenue. There are a
number of parking garages around the GC. There is money to support
parking for interested students, apply to Steve Cowin
(scccc@cunyvm.cuny,edu).

THE LOCATION OF THE BONE SEMINAR ACTIVITIES WITHIN THE GRADUATE CENTER (GC)

When you enter the GC from 5th Avenue there is a reception
counter in the center of a reception room and the elevators are
straight ahead. If you arrive at the GC with a few minutes to spare
before 7 PM you should consider stopping at the 365 Express on the
1st floor for sandwiches, snacks and drinks and to socialize with the
other seminar attendees and the evening's speaker. The 365 Express is
directly off the GC reception room on the 1st floor (the room you
entered from the street), off the southeast corner of the room. The
seminar room is on the 3rd floor (#3309) and accessible by elevator.
Before you are allowed to walk down the hall to the bank of elevators
you must identify yourself to the security people. This can be done
with a CUNY ID or a picture ID (and your signature in a guest book).
When you get off the elevator on the 3rd floor you head east, then
north, then east again to arrive at room 3309.

CLOSING NOTES

Future seminars are posted on www.bonenet.net, a website dedicated to
research on the mechanosensory system in bone. (This website is
operational, but not fully developed and suggestions for further
development of the site would be appreciated.) You may request a
reminder for each seminar by sending an email to Steve Cowin
(scccc@cunyvm.cuny.edu).

We will welcome your attendance and hope that you will pass along
this information to interested colleagues. Please direct your
questions, requests for more information and feedback to me. I thank
Jonathan Kaufman for enhancing the clarity of this communication.

Kind regards, Steve Cowin
--

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Stephen C. Cowin
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New York, NY 10024

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WORK ADDRESS:
Stephen C. Cowin
Director, New York Center for Biomedical Engineering
School of Engineering
The City College
138th Street and Convent Avenue
New York, NY 10031-9198, U. S. A.
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