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Ralph Mueller
05-22-2002, 08:16 AM
Doctoral position in Biomechanics and Bioinformatics

Institute for Biomedical Engineering
Swiss Federal Institute of Technology (ETH) and University of Zürich


LOAD-REGULATED GENES IN BONE

This project is set in the field of experimental biomedical engineering and
connects biology, medicine and engineering.

Bone is a dynamic tissue that can readily adapt to new physiological and
mechanical environments, both in normal day-to-day activities and in
disease. However, the mechanisms for either anabolic (addition of bone mass)
or catabolic (loss of bone mass) bone adaptation are not well understood.
Mechanical loading plays an important role in bone adaptation however little
is known about the mechanisms involved in the load-induced anabolic effects
in trabecular bone, and there is strong evidence that load-regulated genes
play an important role. This project aims to establish an animal model to
study load-induced anabolic activity in trabecular bone, and to identify the
genes related to the trabecular bone adaptation using functional genomics
and bioinformatics.

The successful applicant will adapt, design and build an in-vivo loading
device to apply mechanical load to bone. The device will be compatible for
micro-tomographic imaging of loaded bone, and for biomechanical testing.
Quantitative analysis of the adapted bone will be performed using newly
devised 3D techniques based on the micro-tomographic imaging data as well as
using functional genomics and bioinformatics approaches to find gene
expressed with functional loading of bone. The successful applicant will
work closely with the principal investigator and a post-doctoral fellow, and
will participate in research design, data collection, data
analysis/interpretation and manuscript preparation.

We are looking for a highly motivated, creative and independently working
person with a master of science degree (or equivalent) in either mechanical
or electrical engineering. Design expertise and the willingness to perform
experimentation in small animal models are absolutely required. Applicant
must have very good skills in spoken and written English language to work in
an international, young and dynamic team. Knowledge of German is an
advantage. The position is available immediately.

The project is funded through the ETH Strategic Research Fund. Salaries are
highly competitive and according to the guidelines by the Swiss Federal
Institute of Technology.

A letter of application, a complete curriculum vitae including attended
classes and grades, and a list of two references should be sent to:

Ralph Mueller, Ph.D.
SNF Professor of Bioengineering

Institute for Biomedical Engineering
ETH and University Zuerich
Moussonstrasse 18
8044 Zuerich / Switzerland

tel +41.1.632.4592 fax +41.1.632.1214 www.biomed.ee.ethz.ch/~be

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