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Steve Cowin
10-04-2002, 05:34 AM
To Bone Researchers in the NYC area:
The NYC mineralized tissue seminar will have its second
seminar in the Fall 2002 series on Thursday night, October 10th. The
speaker is Karl Jepsen who is an Assistant Professor in the
Department of Orthopaedics at the Mount Sinai School of Medicine. He
will speak on BONES, GENES, AND EVERYTHING IN BETWEEN. An abstract of
this talk and a description of Karl's research interests are given
below. The same information on the other fall seminar speakers is
posted on www.bonenet.net and will be circulated as the date of each
seminar approaches. If possible, would you please print out the two
attachments and post them at your institution. One is a one-page
announcement of Karl's talk and the other is an announcement of the
Fall 2002 bone seminar series listing all the talks on one page.

OCTOBER 10th, 2002 in room 9205 at the CUNY Graduate Center at 7 PM.

Speaker: KARL J. JEPSEN, PhD, Assistant Professor, Department of
Orthopaedics, Mount Sinai School of Medicine

Title: BONES, GENES, AND EVERYTHING IN BETWEEN

Abstract: Osteoporotic fracture incidence and underlying risk factors
like low peak bone mass are heritable, but the genetic basis of
osteoporosis remains poorly understood. Based on beam theory, stating
that mechanical properties depend on both the amount and quality of a
structure's constituent materials, we investigated the relationship
between whole bone mechanical properties and a set of morphological
and compositional traits in femurs of eight inbred mouse strains.
K-means cluster analysis revealed that individual femora could be
classified reliably according to genotype based on the combination of
bone area (tissue amount), moment of inertia (tissue distribution)
and ash content (tissue quality). This trait combination explained
66-88% of the inter-strain variability in four whole bone mechanical
properties that describe all aspects of the failure process,
including measures of brittleness. Stiffness and maximum load were
functionally linked to cortical area, while measures of brittleness
were linked to ash content. In contrast, work-to-failure was not
directly linked to a single trait but depended on a combination of
trait magnitudes. Based on these findings, which were entirely
consistent with established mechanical theory, we developed a
hierarchical paradigm relating the mechanical properties that define
bone fragility with readily measurable phenotypic traits that exhibit
clear heritability. This paradigm may help guide the search for genes
that underlie fracture susceptibility and osteoporosis; moreover,
because the traits we examined appear to be measurable by
non-invasive means, this approach may also prove directly applicable
to osteoporosis risk assessment.

RESEARCH INTERESTS OF KARL JEPSEN: Major research efforts in
mechanical testing of bone and the effects of heritability on the
mechanical properties of bone.

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POSTER PRESENTATION AT THE SEMINAR: In addition to the podium
speaker, there is the possibility of two poster presentations at each
seminar. The poster boards will be in the room of the podium talk.
The podium talk will begin at 7 PM and the poster presenters are
asked to have their posters up by 6:30 PM and to be available between
6:30 and 7 PM and between 8 and 8:30 PM to discuss their poster with
the attendees. In order to make a poster presentation send Steve
Cowin (scccc@cunyvm.cuny.edu) the following three items for the
announcement of the seminar and posters: (1) poster presenter name
and affiliation, (2) title and abstract and (3) research interests of
the poster presenter. Please transmit this information about 10 days
before the seminar. If there are more than two submissions,
Preference will be given to posters related to the topic talk.
Students would be encouraged to submit posters.
The poster boards supplied by the CUNY graduate school have a
"pin-able" area that is 45 inches wide and about 65 inches tall.
However the bottom of the board is so very low it is only good for
creatures whose eyes are about 20 inches above the ground, thus there
is a usable area of about 45 inches square.

ORGANIZATION OF THE SEMINAR SERIES

The Interinstitutional Steering Committee (ISC) will make decisions
concerning the seminar series, including the selection of speakers.
Interesting, high quality seminar speakers are sought. Seminar
attendees are asked to help in the identification of investigators
with new results relative to the bone research, questions of current
interest and distinguished bone researchers visiting New York City
who might be persuaded to present a seminar. Presentations by
advanced graduate students and post-docs are encouraged.
The members of the Interinstitutional Steering Committee (ISC) are
Adele Boskey (Head of the Mineralized Tissue Section at the Hospital
for Special Surgery and Professor of Biochemistry at the Weill
Medical College of Cornell University), Timothy Bromage (Director of
the Hard Tissue Research Unit and Professor of Anthropology at Hunter
College of CUNY), Stephen C. Cowin (Director of the New York Center
for Biomedical Engineering (NYCBE) and Professor of Biomedical and
Mechanical Engineering at the City College of the City University of
New York (CUNY)), Susannah P. Fritton (Director of the Tissue
Mechanics Laboratory, New York Center for Biomedical Engineering and
Associate Professor of Biomedical Engineering at the City College of
CUNY), X. Edward Guo (Director of the Bone Bioengineering Laboratory
and Assistant Professor of Bioengineering at Columbia University),
Clinton T. Rubin (Professor and Chair of the Department of Biomedical
Engineering, and Director of the Center for Advanced Technology in
Medical Biotechnology at SUNY Stony Brook) and Mitchell B. Schaffler
(Director of Orthopaedic Research and Professor of Orthopedics, Cell
Biology and Anatomy at the Mount Sinai School of Medicine). Each of
these people represents a community consisting of senior bone
research people, graduate students and, in most cases, undergraduate
students.

PLEASE DIRECT YOUR QUESTIONS AND FEEDBACK TO

Stephen C. Cowin
Director, New York Center for Biomedical Engineering
School of Engineering
The City College
138th Street and Convent Avenue
New York, NY 10031-9198, U. S. A.

Phone (212) 799-7970 (Office at Home)
Fax (212) 799-7970 (Office at Home)
Phone (212) 650-5208 (Work)
Email

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Stephen C. Cowin
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Phone (212) 799-7970 (Office at Home)
Fax (212) 799-7970 (Office at Home)
Phone (212) 650-5208 (Work)
Fax (212) 650-6727 (Work)
Email

WORK ADDRESS:
Stephen C. Cowin
Director, New York Center for Biomedical Engineering
School of Engineering
The City College
138th Street and Convent Avenue
New York, NY 10031-9198, U. S. A.
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