Steve Cowin
02-20-2003, 01:55 AM
To Bone Researchers in the NYC area:
The NYC Mineralized Tissue Seminar will have its first spring
seminar on Thursday night February 27th in room C201 at the CUNY
Graduate Center at 7 PM. The speaker is MITCH SCHAFFLER , Mount
Sinai School of Medicine. He will speak on MECHANICAL FACTORS AND
REMODELING OF COMPACT BONE An abstract for the seminar is below.
The Bone Seminar Series has as its focus the mechanosensory
system in bone. The series sponsors eight seminars a year beginning
in September and continuing until April or May. The seminar program
is regularly posted on www.bonenet.net, a website dedicated to
research on the mechanosensory system in bone.



The seminar series will be held in Room C201 (on the concourse level,
below the ground floor) at the CUNY Graduate Center on Thursdays from
7 to 8:30 PM. The CUNY Graduate Center is in the Altman Building at
the corner of 34th Street and 5th Avenue, catty-corner from the
Empire State Building. There will be some socializing before the
seminar in the seminar room from 5:45 PM. Also, from 5:45 PM until 7
PM there will be food (fruit plate, vegetable plate, cookies) and
drink (coffee and soft drinks) available in the seminar room. There
is also a Graduate Center snack bar on the first floor; besides the
usual snacks and drinks the 365 Express also carries beer and wine.
There are several subway lines nearby and it is less than a
ten-minute walk to either Grand Central Station or Penn Station.
There is money to support parking for graduate students, apply to
Steve Cowin (contact information at the bottom).


FEBRUARY 27th, 2003 in room C201 at the CUNY Graduate Center at 7 PM.
(Please note that an earlier announcement indicated a different room

Speaker: MITCHELL B. SCHAFFLER, Ph.D., Professor of Orthopaedics,
Cell Biology and Anatomy & Director of Orthopaedic Research,
Department of Orthopaedics, The Mount Sinai School of Medicine and
Co-Director, New York Center for Biomedical Engineering, City College
of New York


Abstract: Skeletal tissues maintain a balance between mechanical wear
and tear (i.e. fatigue) damage and intrinsic, matrix-level repair.
Imbalance in this damage-repair homeostasis, either because of
excessively rapid damage accumulation or because of ineffective,
inadequate or inappropriate biological responses to chronic injury,
leads to pathology and, ultimately, mechanical failure of skeletal
elements. These processes are implicated in a wide range of
conditions, including overuse injuries, tissue fragility in aging,
tendon and ligament failures and degenerative joint disease.
A major function of Haversian (osteonal) remodeling is to
remove and replace regions of compact bone that accumulate
microdamage due to fatigue. However, little is known about the
damage or remodeling responses that occur at the levels of fatigue
expected to result from normal wear and tear. In particular, how
bone-remodeling units "target" microscopically damaged areas of bone
is unknown. Our recent studies of remodeling-repair of microdamage
find that intracortical resorption effectively removes both
linear-type microcracks and diffuse matrix damage. Alterations of
osteocyte and canalicular integrity are observed in microdamaged
areas. Resorption spaces were also seen within areas of cortex in
which no bone matrix damage occurred, but alterations of osteocyte
and canalicular integrity were evident. Recent studies indicate that
these alterations of osteocyte integrity correspond to osteocyte
apoptosis, or programmed cell death. Thus, osteocyte death or damage
may provide a key stimulus for this signaling or targeting the
remodeling process in bone.

RESEARCH INTERESTS OF MITCH SCHAFFLER: Major research efforts in bone
biomechanics and tissue physiology, with emphasis on understanding
mechanical wear and tear (fatigue) processes in skeletal tissues, and
the cellular/molecular mechanisms used in the detection and repair of
connective tissue matrix injury. Related areas of interest extend to
aging and skeletal fragility, including osteoporosis, and the healing
and regeneration of bone.



The Interinstitutional Steering Committee (ISC) will make decisions
concerning the seminar series, including the selection of speakers.
Interesting, high quality seminar speakers are sought. Seminar
attendees are asked to help in the identification of investigators
with new results relative to the bone research, questions of current
interest and distinguished bone researchers visiting New York City
who might be persuaded to present a seminar. Presentations by
advanced graduate students and post-docs are encouraged.
The members of the Interinstitutional Steering Committee (ISC) are
Adele Boskey (Head of the Mineralized Tissue Section at the Hospital
for Special Surgery and Professor of Biochemistry at the Weill
Medical College of Cornell University), Timothy Bromage (Director of
the Hard Tissue Research Unit and Professor of Anthropology at Hunter
College of CUNY), Stephen C. Cowin (Director of the New York Center
for Biomedical Engineering (NYCBE) and Professor of Biomedical and
Mechanical Engineering at the City College of the City University of
New York (CUNY)), Susannah P. Fritton (Director of the Tissue
Mechanics Laboratory, New York Center for Biomedical Engineering and
Associate Professor of Biomedical Engineering at the City College of
CUNY), X. Edward Guo (Director of the Bone Bioengineering Laboratory
and Assistant Professor of Bioengineering at Columbia University),
Clinton T. Rubin (Professor and Chair of the Department of Biomedical
Engineering, and Director of the Center for Advanced Technology in
Medical Biotechnology at SUNY Stony Brook) and Mitchell B. Schaffler
(Director of Orthopaedic Research and Professor of Orthopedics, Cell
Biology and Anatomy at the Mount Sinai School of Medicine). Each of
these people represents a community consisting of senior bone
research people, graduate students and, in most cases, undergraduate


Stephen C. Cowin
Director, New York Center for Biomedical Engineering
School of Engineering
The City College
138th Street and Convent Avenue
New York, NY 10031-9198, U. S. A.

Phone (212) 799-7970 (Office at Home)
Fax (212) 799-7970 (Office at Home)
Phone (212) 650-5208 (Work)

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