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View Full Version : NYC Bone Seminar on April 10: Helen Lu on DESIGN CONSIDERATIONSIN ORTHOPEDIC TISSUE ENGINEERING OF BONE, SOFT TISSUE,AND INTERFACES



Steve Cowin
04-03-2003, 01:17 AM
To Bone Researchers in the NYC area:
The NYC Mineralized Tissue Seminar will have its second
spring seminar on Thursday night April 10th in room C201 at the CUNY
Graduate Center at 7 PM. The speaker is HELEN LU, Department of
Biomedical Engineering, Columbia University. She will speak on DESIGN
CONSIDERATIONS IN ORTHOPEDIC TISSUE ENGINEERING OF BONE, SOFT TISSUE,
AND INTERFACES. An abstract for the seminar is below.
The Bone Seminar Series has as its focus the mechanosensory system in
bone. The series sponsors eight seminars a year beginning in
September and continuing until April or May. The seminar program is
regularly posted on www.bonenet.net, a website dedicated to research
on the mechanosensory system in bone.

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THE SPRING 2003 BONE SEMINAR PROGRAM

The first three seminar series will be held in Room C201 (on the
concourse level, below the ground floor) at the CUNY Graduate Center
on Thursdays from 7 to 8:30 PM. The fourth seminar on June 5th will
be held in Room 9204. The CUNY Graduate Center is in the Altman
Building at the corner of 34th Street and 5th Avenue, catty-corner
from the Empire State Building. There will be some socializing before
the seminar in the seminar room from 5:45 PM. Also, from 5:45 PM
until 7 PM there will be food (fruit plate, vegetable plate, cookies)
and drink (coffee and soft drinks) available in the seminar room.
There is also a Graduate Center snack bar on the first floor; besides
the usual snacks and drinks the 365 Express also carries beer and
wine.
There are several subway lines nearby and it is less than a
ten-minute walk to either Grand Central Station or Penn Station.
There is money to support parking for graduate students, apply to
Steve Cowin (contact information at the bottom).

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APRIL 10th, 2003 in room C201 at the CUNY Graduate Center at 7 PM.

Speaker: HELEN H. LU, PhD, Department of Biomedical Engineering,
Columbia University.

Title: DESIGN CONSIDERATIONS IN ORTHOPEDIC TISSUE ENGINEERING OF
BONE, SOFT TISSUE, AND INTERFACES

Abstract: Optimal treatment modalities in orthopedics are needed to
meet the demands of an aging yet still active population. Due to
limitations associated with existing biological and synthetic grafts,
tissue engineering has emerged as an alternative approach in
orthopedic repair and regeneration. An area of recent interest is
the design of interfaces to facilitate the integration of bone with
tissues such as muscle, cartilage, ligaments, and tendon. The nature
of the tissue-tissue interface is important in the fixation of
existing implants to bone, and in the integration of a variety of
tissues formed in vitro using tissue engineering approaches.
Development of a bone-soft tissue interface is a highly complex
problem, involving the engineering of both soft and hard tissue, as
well as the interfacial region. This talk will first describe our
research efforts in bone tissue engineering utilizing a composite
scaffold of biodegradable polymers and bioactive ceramics seeded with
bone-forming cells, as well as the use of bone morphogenetic proteins
in promoting mineralization by varied cell sources. Next, results
from our work in tissue engineering of the anterior cruciate ligament
using a three-dimensional, porous, biodegradable, and braided
construct will be presented. The design, in vitro and in vivo
characterizations, and optimization of both soft and hard tissue
engineering constructs will be discussed. Finally, current efforts
in the integration of soft and hard tissues will be described, and
new research directions will be proposed.
RESEARCH INTERESTS OF HELEN LU: Dr. Lu's research focuses on the
regeneration of a functional interface between bone and
ligaments/tendons, as well as the interface connecting bone and
cartilage. Providing a mechanically functional interface between the
biomaterial and bone tissue, and between bone and soft tissue will
significantly improve the long-term stability of the implant. Dr.
Lu's research group at the Biomaterials and Interface Tissue
Engineering Laboratory at Columbia University are developing in vitro
culturing systems to mimic the formation of the interface between
bone and soft tissue (cartilage and ligament) in vivo. These systems
are used to examine the effect of co-culturing on the growth and
differentiation of osteoblasts, chondrocytes and ligament
fibroblasts. Results from these studies are being utilized to design
3-D, tissue engineered scaffold systems that can be applied in the
treatment of osteoarthritis and anterior cruciate ligament injuries.

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ORGANIZATION OF THE SEMINAR SERIES

The Interinstitutional Steering Committee (ISC) will make decisions
concerning the seminar series, including the selection of speakers.
Interesting, high quality seminar speakers are sought. Seminar
attendees are asked to help in the identification of investigators
with new results relative to the bone research, questions of current
interest and distinguished bone researchers visiting New York City
who might be persuaded to present a seminar. Presentations by
advanced graduate students and post-docs are encouraged.
The members of the Interinstitutional Steering Committee (ISC) are
Adele Boskey (Head of the Mineralized Tissue Section at the Hospital
for Special Surgery and Professor of Biochemistry at the Weill
Medical College of Cornell University), Timothy Bromage (Director of
the Hard Tissue Research Unit and Professor of Anthropology at Hunter
College of CUNY), Stephen C. Cowin (Director of the New York Center
for Biomedical Engineering (NYCBE) and Professor of Biomedical and
Mechanical Engineering at the City College of the City University of
New York (CUNY)), Susannah P. Fritton (Director of the Tissue
Mechanics Laboratory, New York Center for Biomedical Engineering and
Associate Professor of Biomedical Engineering at the City College of
CUNY), X. Edward Guo (Director of the Bone Bioengineering Laboratory
and Assistant Professor of Bioengineering at Columbia University),
Clinton T. Rubin (Professor and Chair of the Department of Biomedical
Engineering, and Director of the Center for Advanced Technology in
Medical Biotechnology at SUNY Stony Brook) and Mitchell B. Schaffler
(Director of Orthopaedic Research and Professor of Orthopedics, Cell
Biology and Anatomy at the Mount Sinai School of Medicine). Each of
these people represents a community consisting of senior bone
research people, graduate students and, in most cases, undergraduate
students.

PLEASE DIRECT YOUR QUESTIONS AND FEEDBACK TO

Stephen C. Cowin
Director, New York Center for Biomedical Engineering
School of Engineering
The City College
138th Street and Convent Avenue
New York, NY 10031-9198, U. S. A.

Phone (212) 799-7970 (Office at Home)
Fax (212) 799-7970 (Office at Home)
Phone (212) 650-5208 (Work)
Email

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For bone research information, visit .
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PREFERRED MAILING ADDRESS
Stephen C. Cowin
2166 Broadway
Apartment 12D
New York, NY 10024

Phone (212) 799-7970 (Office at Home)
Fax (212) 799-7970 (Office at Home)
Phone (212) 650-5208 (Work)
Fax (212) 650-6727 (Work)
Email

WORK ADDRESS:
Stephen C. Cowin
Director, New York Center for Biomedical Engineering
School of Engineering
The City College
138th Street and Convent Avenue
New York, NY 10031-9198, U. S. A.
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For information about the New York Center for Biomedical
Engineering visit
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