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Amit Bhrany
04-12-2003, 08:00 AM
Hello,

My name is Amit Bhrany, and I am conducting burst pressure studies on rat
esophagi. I insert a 22-guage catheter into the lumen of an approximately
10-mm segment of rat esophagi. I then affix the proximal end of the
esophagus to catheter via a suture and close the distal end in the same
manner. I infuse saline at a constant rate into the esophagus until it
bursts. My main goal is to determine the bursting pressure of each
esophageal segment.

I have two questions. The first is that when I tie off the esophagi, the
length of the segments are not always constant. They range from 7-13 mm in
length. I would think that as long as I am only concerned with the burst
pressure of the walls of the esophagus in a closed system, that the
differences in length should not affect the actual burst pressure. Is the
preceding really true, or can I not compare burst pressures of esophagi with
differing lengths?

My second question stems from the fact that the catheter is not always
inserted the exact same length into the lumen of the esophagus. When the
esophagus bursts, the wall is not touching the catheter, but is it safe to
assume that the amount of volume the catheter takes up does not affect the
measurement?

I thank you all for your consideration and would appreciate any assistance
you could provide.

Sincerely,


Amit


--
Amit Bhrany M.D.
Department of Otolaryngology- Head and Neck Surgery
University of Washington
Box 356515
Seattle, WA 98195

abhrany@u.washington.edu
(206) 221-5828: office
(206) 340-7869: pager

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