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Tammy Haut Donahue
04-29-2003, 09:24 PM
A graduate student fellowship is available beginning the 2003-2004 academic
year to study knee biomechanics. The primary focus of our research group
is to understand how mechanical signals are transduced in the meniscus. The
research will involve the creation of a microstructural finite element
model of the knee joint. The results of the theoretical FEM will be used
as input for a biological models to study the biochemical signaling
pathways in menisci following exposure to mechanical stimuli. This will
involve the stimulation of meniscal cells in vitro using a parallel plate
flow chamber and compression of meniscal explants to quantifying
intracellular signaling mechanisms such as cytosolic calcium oscillations,
and gene and protein expression. Both experimental and computational
approaches will be used to study the response of menisci to mechanical
stimulation to understand diseases like osteoarthritis.

Michigan Technological University is located in Michigan's Upper Peninsula.
The community offers a small-town environment with outstanding four-season
recreational opportunities.

Applicants should have a B.S. or M.S. in Mechanical Engineering, Biomedical
Engineering, or a closely related field. Prior work in finite element
modeling and theoretical mechanics is helpful. Send a statement of interest
and a resume or CV to:


Tammy Haut Donahue
Department of Mechanical Engineering
Michigan Technological University
1400 Townsend Dr.
Houghton, MI 49931

thdonahu@mtu.edu
www.me.mtu.edu/~thdonahu
voice (906)487-2078
fax (906)487-2822

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