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Steve Cowin
05-02-2003, 09:31 AM
>Date: Fri, 2 May 2003 19:26:15 -0400
>To: BIOMCH-L@NIC.SURFNET.NL
>From: Steve Cowin
>Subject: NYC Bone Seminar on April 10: Steve Cowin on BONES HAVE EARS
>Cc:
>Bcc:
>X-Attachments:
>
>To Bone Researchers in the NYC area:
> The NYC Mineralized Tissue Seminar will have its third spring
>seminar on Thursday night May 8th in room C201 at the CUNY Graduate
>Center at 7 PM. The speaker is STEVE COWIN, Departments of
>Biomedical and Mechanical Engineering, CCNY. He will speak on BONES
>HAVE EARS. An abstract for the seminar is below.
> The Bone Seminar Series has as its focus the mechanosensory
>system in bone. The series sponsors eight seminars a year beginning
>in September and continuing until April or May. The seminar program
>is regularly posted on www.bonenet.net, a website dedicated to
>research on the mechanosensory system in bone.
>
>XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
>
>THE SPRING 2003 BONE SEMINAR PROGRAM
>
>The first three seminar series will be held in Room C201 (on the
>concourse level, below the ground floor) at the CUNY Graduate Center
>on Thursdays from 7 to 8:30 PM. The fourth seminar on June 5th will
>be held in Room 9204. The CUNY Graduate Center is in the Altman
>Building at the corner of 34th Street and 5th Avenue, catty-corner
>from the Empire State Building. There will be some socializing
>before the seminar in the seminar room from 5:45 PM. Also, from 5:45
>PM until 7 PM there will be food (fruit plate, vegetable plate,
>cookies) and drink (coffee and soft drinks) available in the seminar
>room. There is also a Graduate Center snack bar on the first floor;
>besides the usual snacks and drinks the 365 Express also carries
>beer and wine.
>There are several subway lines nearby and it is less than a
>ten-minute walk to either Grand Central Station or Penn Station.
>There is money to support parking for graduate students, apply to
>Steve Cowin (contact information at the bottom).
>
>XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
>
>MAY 8th, 2003 in room C201 at the CUNY Graduate Center at 7 PM.
>
>Title: BONES HAVE EARS
>
>Abstract: The structural adaptations of living require a cell-based
>mechanosensing system with a sensor cell that perceives the
>mechanical deformation of the mineralized matrix in which the cell
>resides, a cell-based mechanosensing system not unlike that in the
>ear. One of the most perplexing features of this mechanosensory
>system in bone is the very low strain level that a whole bone
>experiences in vivo compared to that needed to produce a response in
>cells. The amplitudes of the in vivo strains generally fall in the
>range 0.04 to 0.3 percent for animal locomotion and seldom exceed
>0.1 percent. These strains are nearly two orders of magnitude less
>than those needed (1% to 10%) to elicit biochemical signals
>necessary for communication of the sensing cells with the cells that
>deposit and resorb bone tissue. There is a paradox in the bone
>mechanosensing system in that the strains that activate the bone
>cells are at least an order of magnitude larger than the strains to
>which the whole bone organ is subjected. A hierarchical model
>ranging over length scales that differ by 9 orders of magnitude,
>from the subcellular level to the whole bone level, is used to
>resolve this paradox. Using this extended model, it is possible to
>explain how the fluid flow around a bone cell process can lead to
>strains on the cell process structure that are two orders of
>magnitude greater than the ambient strains in the mineralized matrix
>in which the cell resides. This bone mechanosensory system has many
>features in common with the auditory system.
>
>
>RESEARCH INTERESTS OF STEVE COWIN: His principal research interest
>is the mechanics of materials, particularly in determining the
>influence of microstructure on the gross mechanical behavior of
>granular, composite, and biological materials. He concentrated on
>bone mechanics for many years and has been interested in tissue
>building process in skeletal tissues in recent years.
>
>XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
>
>ORGANIZATION OF THE SEMINAR SERIES
>
>The Interinstitutional Steering Committee (ISC) will make decisions
>concerning the seminar series, including the selection of speakers.
>Interesting, high quality seminar speakers are sought. Seminar
>attendees are asked to help in the identification of investigators
>with new results relative to the bone research, questions of current
>interest and distinguished bone researchers visiting New York City
>who might be persuaded to present a seminar. Presentations by
>advanced graduate students and post-docs are encouraged.
>The members of the Interinstitutional Steering Committee (ISC) are
>Adele Boskey (Head of the Mineralized Tissue Section at the Hospital
>for Special Surgery and Professor of Biochemistry at the Weill
>Medical College of Cornell University), Timothy Bromage (Director of
>the Hard Tissue Research Unit and Professor of Anthropology at
>Hunter College of CUNY), Stephen C. Cowin (Director of the New York
>Center for Biomedical Engineering (NYCBE) and Professor of
>Biomedical and Mechanical Engineering at the City College of the
>City University of New York (CUNY)), Susannah P. Fritton (Director
>of the Tissue Mechanics Laboratory, New York Center for Biomedical
>Engineering and Associate Professor of Biomedical Engineering at the
>City College of CUNY), X. Edward Guo (Director of the Bone
>Bioengineering Laboratory and Assistant Professor of Bioengineering
>at Columbia University), Clinton T. Rubin (Professor and Chair of
>the Department of Biomedical Engineering, and Director of the Center
>for Advanced Technology in Medical Biotechnology at SUNY Stony
>Brook) and Mitchell B. Schaffler (Director of Orthopaedic Research
>and Professor of Orthopedics, Cell Biology and Anatomy at the Mount
>Sinai School of Medicine). Each of these people represents a
>community consisting of senior bone research people, graduate
>students and, in most cases, undergraduate students.
>
>PLEASE DIRECT YOUR QUESTIONS AND FEEDBACK TO
>
>Stephen C. Cowin
>Director, New York Center for Biomedical Engineering
>School of Engineering
>The City College
>138th Street and Convent Avenue
>New York, NY 10031-9198, U. S. A.
>
>Phone (212) 799-7970 (Office at Home)
>Fax (212) 799-7970 (Office at Home)
>Phone (212) 650-5208 (Work)
>Email


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For bone research information, visit .
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PREFERRED MAILING ADDRESS
Stephen C. Cowin
2166 Broadway
Apartment 12D
New York, NY 10024

Phone (212) 799-7970 (Office at Home)
Fax (212) 799-7970 (Office at Home)
Phone (212) 650-5208 (Work)
Fax (212) 650-6727 (Work)
Email

WORK ADDRESS:
Stephen C. Cowin
Director, New York Center for Biomedical Engineering
Departments of Biomedical and Mechanical Engineering
The City College
138th Street and Convent Avenue
New York, NY 10031-9198, U. S. A.
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For information about the New York Center for Biomedical
Engineering visit
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