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pmchugh39
11-07-2004, 10:17 PM
National Centre for Biomedical Engineering Science (NCBES) and the
Regenerative Medicine Institute (REMEDI)




The National Centre for Biomedical Engineering Science (NCBES) is an
interdisciplinary Research Institute at NUI, Galway, established in 1999. In
2003 the Regenerative Medicine Institute (REMEDI) at the NCBES was
established, through an SFI Centre for Science Engineering and Technology
(CSET) award. The goal of REMEDI is to explore the synergies of gene therapy
and adult stem cell therapy to promote tissue repair and regeneration.



Applications are invited for the following Ph.D. postgraduate project
starting spring 2004.



"Investigation of gene delivery from a coated stent"



This project focuses on exploring the area of gene delivery from a polymer
coating on a vascular stent. The background to the project is the use of
gene therapy to deal with restenosis - the reclosure of arteries that has
been shown to occur following balloon angioplasty in a sizable proportion of
cases. The project will involve fundamental experimental studies of gene
elution from polymer coating samples to determine release kenetics, coupled
with an experimental characterization of the polymer coating itself. Using
this fundamental information, a combined experimental-computational study
will be performed to investigate gene delivery from a coated stent in a
realistic anatomical setting. The computational study will involve finite
element simulation of gene elution from a stent, as a function of stent
geometry; this will be validated by in-vitro experimental studies in a
bioreactor where realistic pulsatile physiological flows can be applied.
This will be followed by pre-clinical evaluation. The project has the
overall aim of understanding the fundamentals of vascular stent based gene
delivery and, based on this, developing a stent design for optimum
effectiveness.



Qualifications:

Applicants for this position will ideally have a primary degree (H2.1 or
higher) in biomedical engineering, mechanical engineering or materials
engineering or in a related discipline. A competitive fellowship package,
including university fees and a monthly stipend, is on offer.



For informal discussion contact:



Prof. Peter McHugh

Department of Mechanical and Biomedical Engineering, NUI, Galway

Tel: +353 (0)91 750490, e-mail:
peter.mchugh@nuigalway.ie

www.nuigalway.ie/ncbes and www.nuigalway.ie/mecheng



Applicants should submit their CV with the names and addresses of three
referees, by either e-mail or hardcopy, to: Ms Emma Brinton, NCBES, NUI,
Galway, Ireland, e-mail: emma.brinton@nuigalway.ie. Closing date: Friday,
January 14th, 2005.



The National University of Ireland, Galway is an equal opportunities
employer.





Professor Peter E. McHugh

Department of Mechanical and Biomedical Engineering and

National Centre for Biomedical Engineering Science

National University of Ireland, Galway

Galway, Ireland

Tel: +353 (0)91 750490/524411 x3152

Fax: + 353 (0)91 563991/750596

E-mail: peter.mchugh@nuigalway.ie




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