View Full Version : pediatric tissue information request.

Alex Depaula
04-02-2007, 12:40 AM
This is a response to Al Vangura Jr. who was looking for pediatric
tissue for research:

C. Alex DePaula, Ph.D.
Senior Scientist
Musculoskeletal Transplant Foundation, 125 May Street, Edison, NJ 08837.
Voice: 732-661-2261, Fax: 732-661-2309

-----Original Message-----
From: Jeff Dauber
Sent: Monday, April 02, 2007 10:26 AM
To: Alex DePaula
Cc: Mike Real; Christine Norton
Subject: RE: [BIOMCH-L] Paediatric Cadavers

Hello Alex,

Hope all is well.

IIAM has received some pediatric donors. These types of referrals are
rare (to IIAM) I can't speak for other similar programs or for the
Medical college programs though I would imagine that this type of
donation would be rare in those settings as well. We sometimes get
offered tissues from full term still born infants or other very young
infant tissues.

Our donor development is focused primarily around the geriatric
community as well as Hospice. I can get the thoughts of our development
team regarding potential sources of this type of tissue.

Oddly enough we (IIAM) currently have the upper and lower extremities
from a 6 year old female. The tissue was donated 3 years ago and we have
not been able to find placement. If you know of an interested party
please let me know. I can have our client services supervisor (Christine
Norton) contact them and relay pertinent information. Thanks

Jeff Dauber
Associate Director IIAM

-----Original Message-----
From: * Biomechanics and Movement Science listserver
Behalf Of Al Vangura Jr.
Sent: Friday, March 23, 2007 2:14 PM
Subject: Re: [BIOMCH-L] Paediatric Cadavers

Thanks to all who responded.

Responses to my posting yesterday are listed below which revealed two
major points:

1) there is ample interest in this topic

2) It will be extremely difficult to acquire paediatric cadaveric
tissues for research

An additional question for the list.... Is there anything that we can do
as a group to educate the public about the need for parents to offer
donations which can lead to decreased injury for other children, even
after the untimely loss of their own child? Example... could a petition
be sent to CPSC or FDA in an attempt to educate them about the need for
paediatric cadavers for injury research?

Peter Davidson wrote: I have been investigating arm fracture in children
that last 7 years using computer modelling. I have not used cadaver data
but I'm very interested in your request. Do you have more information
about your research? We should keep in contact. Below are my
publications in this area. I can send you pdfs if you like.

Alicia Koontz wrote: I would think that ped cadavers would be pretty
hard to find. Well, I don't know anything about ped failure loads, but
BC Deemer, a pretty far along PhD student over in RST at one point in
his long research career investigated ped falls and developed computer
models and simulations to evaluate whether fractures could occur in a
given 'fall' situation so he would have to have some information about
loading tolerances. I'm not sure he is on the list to see your message,
but you can try emailing him.

Qingan Zhu, Ph.D. wrote: I did the three-point bending failure tests on
the humeral, radius and ulna of children (2-12) couple years ago when I
worked in China. Please let me know if it helpful.

Kevin Miller wrote: If you get any response to this, would you mind
letting me know? I am working on the lower extremity and would love to
get some feet. Thank you in advance.

Andrew Mahar wrote: You can contact NDRI based in Philadelphia on this
issue. However, I have never been able to obtain pediatric specimens in
amounts to actually conduct a study. We do pediatric spine, trauma and
hip research and nearly all of our data comes from experimental or
numerical modeling. Jason R. Kerrigan wrote: I would be surprised if you
were able to legally obtain any pediatric post mortem tissue in the
United States. As you are likely aware, there is amassive need for
pediatric injury criteria and constitutive models in the automotive
safety field for dummy/computational model development/improvement.
However, even universities with long histories of research exemplifying
the highest technical (and ethical) standards are virtually unable to
obtain such tissue. However, this remains a dynamic situation and thus I
would be interested inany responses you get.

Michael Dahl wrote: You're going to have a hard time finding pediatric
specimens. Research we've done on spine injuries using pediatric
specimens were mostly done using baboons, and the data were then
multiplied by a scaling factor to approximate children. We were able to
validate our scaling factors by testing a handful of pediatric tissues,
but each specimen had to be personally obtained by discussing the
research with parents who had lost their children to accidental
circumstances or suicide. Since the research was for car crash safety, a
couple families decided that it was a worthy contribution. I would look
into an animal model, since there is a lot of data on scaling already,
it is cheaper, and easier to obtain.

J. Marcus Hollis wrote: In general they are not available at that age in
my experience. You might have to go to mathematical or animal models.
Ekin Akalan wrote:

you may take a look at www.lifemodeller.com
they have impact contact tutorial.
You may have get some benefit from tutorials

> Date: Thu, 22 Mar 2007 11:28:38 -0400> From: avangura@HOTMAIL.COM>
> Subject: [BIOMCH-L] Paediatric Cadavers> To: BIOMCH-L@NIC.SURFNET.NL>

> > Hello list,> I am attempting to examine the failure loads of the
> forearm during falls to the outstretched hands of children. Can anyone

> supply contact information for groups who could provide cadaveric
> upper extremities for children ages 5-12 years old? Thank you in
> advance.> > Regards,> > Al Vangura Jr.> Keystone Engineering
> Consultants, Inc> 724-255-7176>

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