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Steve Cowin
02-03-2008, 07:24 AM
Hi Folks:

The Spring 2008 Bone Seminar Series begins on February 19th with a
seminar presented by Bob Majeska (Mount Sinai) entitled Bone
Remodeling and Skeletal Metastasis: Making Things Too Cozy?

Details about all seminars appear below as well as on our website:
http://bonenet.net

The contents of the rest of this email are as follows:
[1] Bone Seminar Series: General Information
[2] February 19th, 2008 Bob Majeska (MSSM); Host; Karl Jepson
[3] March 18th, 2008 Van P. Thompson, (NYU Dental) Host; Tim Bromage
[4] April 8th, 2008 Steven R. Goldring (HSS) Host: Ericka Calton
[4] May 13th, 2008 Peter S. Walker (NYU-HJD) Host: Steve Cowin

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THE BONE SEMINAR SERIES

The Bone Seminar Series has as its focus the mechanosensory system in
bone. Seminar program and workshop information are regularly posted
on www.bonenet.net, a website dedicated to research on the
mechanosensory system in bone. Please send comments on the website to
the webmaster, Bill Green or to me
.

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THE SPRING 2008 BONE SEMINAR PROGRAM

The seminars this Spring will be held on Tuesdays from 7:00 to about
8:30 PM in the rooms indicated in the CUNY Graduate Center at the
corner of 34th Street and 5th Avenue, catty-corner from the Empire
State Building. There are several subway lines nearby, and it is less
than a ten-minute walk to either Grand Central Station or Penn
Station. There is money to support parking for graduate students;
apply to Steve Cowin (contact information at the bottom).

SOCIAL BEFORE EACH SEMINAR

Before each seminar, please join us for an hour or so of socializing
and exchanging ideas beginning at 5:45 PM (to 6:45). All seminar
attendees are invited to gather at the Heartland Brewery (see below)
prior to the presentation. The speakers and others will be downstairs
at the Heartland Brewery starting at 5:45 PM. Appetizers will be
provided as well as non-alcoholic beverages. Supplemental beverages
(i.e, alcoholic) will require out-of-pocket cash. Please note that
there will be no food or beverages provided at the seminar so come
early to the Heartland for both and for good conversations. Ask
downstairs at the Heartland Brewery for the Bone Seminar Group.

Heartland Brewery
350 5th Ave (Corner of 5th and 34th--Empire State Building-
Across 5th from the CUNY Graduate Center)
212 563 3433

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Tuesday February 19, 2008 _CUNY Graduate Center, Room 9204, 7:00 PM
Speaker: Robert J. Majeska, PhD, Department of Orthopaedics, Mount
Sinai School of Medicine
Host: Karl Jepson, Mount Sinai School of Medicine
Topic: Bone Remodeling and Skeletal Metastasis: Making Things Too Cozy?__

Dr. Majeska's Research Interests: Cell biology of bone and related
connective tissues; the contribution of fundamental cell-level
processes (e.g., proliferation, differentiation and responsiveness to
environmental stimuli) to tissue-level processes (e.g., growth,
modeling/remodeling, repair, cancer). Specific interests lie in
cell-matrix interactions, fracture healing, and metastasis.

Abstract: Certain forms of cancer, including breast and prostate
carcinoma, preferentially metastasize to the skeleton, and indeed
appear to prefer certain sites within certain bones. Responsibility
for this tissue- and site-selectivity is thought to lie largely with
bone itself, following Paget's century-old "seed-and-soil" hypothesis
that metastasis depends on the ability of remote host tissues to
provide a favorable environment for the survival and growth of tumor
cells. Both experimental evidence and clinical experience have
supported Paget's hypothesis as it relates to skeletal metastasis,
and have implicated bone remodeling, particularly bone resorption, as
its underlying mechanistic basis. In this presentation, I will review
evidence that bone resorption favors the development of metastatic
lesions in bone by promoting the growth and survival of tumor cells
present in bone or marrow, describe results from our laboratory
indicating that resorption may also regulate even earlier steps in
metastasis, i.e., initial arrest and extravasation of circulating
tumor cells, and finally discuss the use and effectiveness of bone
resorption inhibitors like bisphosphonates as antimetastatic agents.

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Tuesday March 18, 2008 _CUNY Graduate Center, Room 9204, 7:00 PM_
Speaker: Van P. Thompson, DDS, PhD, Professor and Chair, Department
of Biomaterials and Biomimetics, NYU College of Dentistry
Host: Tim Bromage, NYU College of Dentistry
Topic: Enamel: Nature's Epithelially Derived, Damage-tolerant Ceramic__

Dr. Thompson's Research Interests: Tissue adhesion to metal and
ceramics, fatigue and damage in biomaterials, engineering of tissue
response to scaffold structures.

Abstract: Recent studies have elucidated the damage and fatigue modes
of ceramic layer structure analogs of enamel supported by dentin.
Conventional static tests indicate that dental crown porcelains and
structural ceramic cores are stronger than enamel, while fatigue
testing indicates that enamel has evolved to accommodate damage modes
that cause clinical failure in all-ceramic crowns. The lecture will
compare the fatigue and failure modes of ceramics with enamel.
Emphasis will be on how the enamel structure, including rod and rod
decussation, limit damage. Evidence suggesting self-repair of enamel
will be presented.

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Tuesday April 8, 2008 _CUNY Graduate Center, Room 9206, 7:00 PM_ __
Speaker: Steven R. Goldring, MD, St. Giles Chair and Chief Scientific
Officer, Hospital for Special Surgery, Weill Medical College of
Cornell University
Host: Adele Boskey, Ericka F. Calton, Ph.D. Candidate (BME), CCNY, HSS
Topic: Role of Cell-Substrate Interactions: Pathology Teaches Physiology__

Dr. Goldring's Research Interests: Osteoclast biology, mechanisms of
pathologic bone remodeling

Abstract: Osteoclasts are derived from monocyte/macrophage lineage
precursors that are recruited to the bone microenvironment where
locally produced cytokines and growth factors, as well as endocrine
hormones, induce their differentiation into actively resorbing
osteoclasts. Of interest, in both physiologic and pathologic bone
resorption, cells expressing the full morphological and functional
properties of mature osteoclasts are almost invariably restricted to
the immediate bone surface (Shen et al. Arthritis Res Ther, 2006).
This observation suggests that interaction of osteoclast precursors
with the bone substrate may provide signals that are essential for
the terminal differentiation and activation of resorbing osteoclasts.
We have used transcriptional profiling of osteoclasts differentiated
on defined substrates to gain insights into the molecular pathways by
which cell-matrix interactions regulate the genetic repertoire and
functional properties of osteoclasts. Transcriptional analysis was
performed using oligonucleotide array expression profiling on
Affymetrix Mouse Genome 430 2.0 GeneChips. Results were validated
using quantitative RT-PCR. Following microarray normalization and
gene comparison, hierarchical clustering was performed and pathways
regulated by bone matrix adherence identified using the Ingenuity
Pathway Analysis program. In preliminary studies we have identified
genes and molecular pathways that are uniquely regulated by
interaction of osteoclast precursors with the mineralized bone
substrate. The expression of these osteoclast-associated genes has
been verified in vivo by examining their expression pattern in
tissues from patients with specific forms of pathologic
osteoclast-mediated bone resorption. These genes represent potential
novel molecular targets for inhibiting osteoclast-mediated bone
resorption in disorders associated with pathologic bone loss.

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Tuesday May 13, 2008 _CUNY Graduate Center, Room 9204, 7:00 PM_Click
here for directions to the CUNY Graduate Center
Speaker: Peter S. Walker PhD, Professor, Department of Orthopaedic Surgery,
NYU Hospital for Joint Diseases
Host: Steve Cowin, City College of New York
Topic: Can Knee Replacements be Improved? A Holistic View

Dr. Walker's Research Interests: Biomechanics of joints,
osteoarthritis, design and evaluation of artificial joints,
computer-assisted surgery for joint replacement.

Abstract: Almost 40 years of evolution have resulted in artificial
knee designs and surgical techniques, which provide the patient with
restoration of function for over two decades in the majority of the
patients. Further improvements in function could likely be achieved
by the use of more conservative implants, and by earlier intervention
than is the norm for total knees. Even at the stage of carrying out a
TKR, recent research shows that a significant percentage could be
treated with a unicompartmental replacement. However, the function of
total knees themselves could possibly be improved using guided-motion
designs which restored the normal neutral path of motion, and which
provided the optimal laxity and stability during the flexion range.
Finally, in order to obtain consistent alignment and soft tissue
tensions at surgery, more quantitative techniques are required, with
computer-assisted surgery being a promising approach. Research
studies will be described which address the various facets noted
above.

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ORGANIZATION OF THE SEMINAR SERIES

The Interinstitutional Steering Committee (ISC) will make decisions
concerning the seminar series, including the selection of speakers.
Interesting, high quality seminar speakers are sought. Seminar
attendees are asked to help in the identification of investigators
with new results relative to bone research, questions of current
interest and distinguished bone researchers visiting New York City
who might be persuaded to present a seminar. Presentations by
advanced graduate students and post-docs are encouraged.

The members of the Interinstitutional Steering Committee (ISC) are
Adele Boskey (Head of the Mineralized Tissue Section at the Hospital
for Special Surgery and Professor of Biochemistry at the Weill
Medical College of Cornell University), Timothy Bromage (Director,
Hard Tissue Research Unit, New York University College of Dentistry),
Stephen C. Cowin (Professor of Biomedical and Mechanical Engineering
at the City College of the City University of New York (CUNY)),
Susannah P. Fritton (Director of the Tissue Mechanics Laboratory, New
York Center for Biomedical Engineering and Associate Professor of
Biomedical Engineering at the City College of CUNY), X. Edward Guo
(Director of the Bone Bioengineering Laboratory and Associate
Professor of Bioengineering at Columbia University), Clinton T. Rubin
(Professor and Chair of the Department of Biomedical Engineering, and
Director of the Center for Advanced Technology in Medical
Biotechnology at SUNY Stony Brook) and Mitchell B. Schaffler
(Director of Orthopaedic Research and Professor of Orthopedics, Cell
Biology and Anatomy at the Mount Sinai School of Medicine). Each of
these people represents a community consisting of senior bone
research people, graduate students and, in most cases, undergraduate
students.

PLEASE DIRECT YOUR QUESTIONS AND FEEDBACK TO

Stephen C. Cowin
New York Center for Biomedical Engineering
Departments of Biomedical and Mechanical Engineering
School of Engineering
The City College
138th Street and Convent Avenue
New York, NY 10031-9198, U. S. A.

Phone (212) 799-7970 (Office at Home)
Fax (212) 799-7970 (Office at Home)
Phone (212) 650-5208 (Work)
Email