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kpark58
03-05-2008, 03:53 PM
Dear Subscribers



I am trying to create an appropriate model of a coronary arterial system
for testing the ease of deliverability of catheters (designed to be
delivered through a guiding catheter introduced through the femoral
artery, and then to the lesion in the diseased coronary artery), both
qualitatively (assessment by cardiologists) and quantitatively
(equipping the rig with a load cell). I have used glass tubes and
silicone tubes to simulate the arteries at various times, but neither
approximates the artery in an ideal way (i.e. cardiologists subjectively
determine that they approximate the arteries). I have also heard of
people using HP-PE (e.g. Schmidt et al. of Rostock University). Although
there is a lot of literature to be found with respect to model artery
compliance, frictional properties are harder to find. I have two
questions related to this and would appreciate any comments from
subscribers:



1. Is anyone aware of studies that show that a certain tubing
material offers a better simulation for arterial friction? I perform the
tests at 37C with flowing PBS. There are of course advantages to using
flexible polymer materials so that the artery geometry can be altered,
but I can live without this requirement. Is there any literature
comparing tubing performance for my application or similar?
2. Does anyone know whether I can obtain access to a database or
other collection of coronary artery measurements, particularly
curvature, either from cadaveric study or from 3d imaging techniques, to
aid in setting up typical as well as challenging anatomy for testing
catheters (particularly for stent delivery)?



Kind Regards

Ken Park

DISA Vascular

Cape Town, South Africa