View Full Version : Cardiovascular Physiology and Foreign Agents

Michael Markes
05-05-1994, 12:13 AM
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> From: Michael Markes
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> Subject: Cardiac Physiology and Foreign Agents
> To: BIOMICH-L@HEARN.nic.SURFnet.nl
> Date: Wed, 4 May 94 23:22:24 EDT
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> Fellow Subscribers,
> I am currently an undergraduate student at Michigan Technological University
> who is in the middle of a final project for an advanced Cardio-Pulminary
> Physiology class. For our final project, we have to design a laboratory
> experiment of our own choosing, run the experiment, and document the results
> in a highly detailed oral and written presentation at the end. I chose to
> utilize ECG to examine the effects of various COMMON stimuli and foreign
> agents on the human body. Since we are using ourselves and a limited number
> of volunteers as subjects, and the experiment is being performed in an
> undergraduate setting, we were only limited to certain chemicals and drugs.
> Since we are not allowed to use common high scale vaso-constrictors and
> vaso-dialators such as Acetylcholine, Epinephrin, and Norepinephrin, which are
> common to experimentation, I decided to expose the heart to heat, cold,
> caffeine, nicotene, alcohol, stair-climbing, sodium, sugar, and anti-inflamm.
> drugs. For all of these stimuli, we are looking at changes in blood pressure;
> changes in heart rate; incidenses of max/min ventricular rate; voltage
> changes indicated by the electro-cardiogram trace; changes in P-wave, QRS,
> T-wave structure and duration; and how all of these aspects vary with time,
> differences in age, weight, and gender. For the stimuli, we are using a
> localized ice bath at a limb away from the heart for the cold due to varying
> levels of sesitivity in our subjects and safety reasons, verses icing the
> chest cavity. We are using a sauna for heat, Vivarin for caffeine, chewing
> tobacco for the source of nicotine, 32oz. of beer for the alcohol, and motrin
> for the anti-inflammatory drug. We have been conducting our experiments for
> the last month and have collected all of our data that we have obtained
> visually, manually, and via the Cardiocomp7 pc-based program that we are
> using.
> Now that we have collected our data, we would like to compare it with similar
> studies and obtain more standard information to help with better interpreting
> our data. I am in search of any information from previous studies pertaining
> to any of the stimuli that we are using. Recent studies dealing with short-
> term effects caused by variances in temperature, caffeine, and nicotene would
> strongly be appreciated. For studies using nicotine, the necessary comparing
> studies would be those using nicotine gum verses cigarette smoking because we
> are not considering CO affects in our experiment. If anyone knows of any
> information pertaining to these stimulants and their direct cardiac effects,
> or where information can be found, please feel free to post it or e-mail me
> direct. All information recieved will greatly be appreciated and considered.
> Thanks in advance!
> Michael W. Markes
> Biomedical Engineering
> Michigan Technological University
> mwmarkes@mtu.edu