View Full Version : MEDNEWS and VSPLINE

Herman J. Woltring
05-20-1990, 10:22 PM
Dear Biomch-L readers,

The following items were retrieved from MEDNEWS issues HICN316 NWS and HICN317
NWS, as retrieved from LISTSERV@ASUACAD via the request SEND HICN31n NWS:


A three-year study of a treatment for postmenopausal osteoporosis published
in Tuesday's New England Journal of Medicine shows oral diphosphonate therapy
increases bone mass in the spine and decreases the incidence of spinal
fractures. The National Osteoporosis Foundation, dedicated to prevention and
treatment of osteoporosis, is optimistic about the study.


A common but little-talked-about problem among women could discourage
exercising. A study of 326 women by University of Michigan Medical researchers
shows almost half report involuntary urination during exercise. The problem
may be treated with surgery, but doctors recommend changing activities and
avoiding liquids. (From the USA TODAY Life section.)


Major discoveries in the fight against AIDS, arthritis, and septic shock
were announced at the annual meeting of the American Federation for Clinical
Research, the American Society for Clinical Investigation and the Association
of American Physicians. The findings underscore the importance of increased
federal funding for continued research for the cure or improved treatment of


West German researchers studied patients suffering from severe rheumatoid
arthritis that had shown no positive response to conventional drug therapies.
Seven out of 10 patients showed measurable responses to monoclonal antibody
16H5, which was able to halt the progression of the disease for up to one
year. For more information contact: Christy Eagleton, AFCR, 202-223-0030.


VSPLINE from Netlib@research.att.com

Following the Biomch-L discussions on various signal processing methods, it may
be useful to mention a new procedure w.r.t. earlier spline methods. It is for-
matted for processing on a UNIX system, but manual preprocessing for use on a
different system should not be too difficult:

vspline Jeff Fessler, Stanford University
The VSPLINE package contains a set of C subroutines that computes a
non-parametric estimate of a smooth vector-valued function from noisy
measurements. The method is a natural generalization of (scalar)
cubic-spline smoothing. The algorithm is described in full in
"Non-parametric fixed-interval smoothing with vector splines" by Jeff
Fessler, submitted to IEEE Transactions on Acoustics, Speech, and
Signal Processing. (See also gcvspl.)

Send the following requests (lower case, one per line) to the Netlib fileserver
at AT&T Bell Research Labs in Murray Hill, NJ/USA, at the Internet address

send index for gcv
send vspline for gcv

(Intrigueingly, the package is one of the first on Netlib to contain a lengthy
Copyright statement with the nature of a so-called `shrink-wrap licence' for
non-commercial use. It is doubtful under any applicable law whether this li-
cence is legally enforceable without an explicit signature by a retriever of the
package, but default conditions under intellectual property law must be deemed
to apply, e.g., the Fair Use / Fair Dealing provisions under Anglo-American law
and their counterparts in other jurisdictions).


Herman J. Woltring, Eindhoven/NL
(Absent from May 23 to May 29, 1990)