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pschneider62
01-14-2011, 05:17 AM
PhD Position in Bioimaging/Biomechanics at
ETH Zurich and The University of Sydney

Job description

The Institute for Biomechanics (http://www.biomech.ethz.ch/) at ETH Zurich (http://www.ethz.ch/index_EN), in collaboration with Orthopaedic Research at The University of Sydney (http://sydney.edu.au/) is seeking to appoint a highly motivated PhD candidate pursuing research in the areas of Bioimaging/Biomechanics. The successful candidate will work within an international and interdisciplinary team of biologists, engineers and physicists at ETH Zurich and will have the opportunity to collaborate closely with the Swiss Light Source (SLS) (http://sls.web.psi.ch/) of the Paul Scherrer Institut (PSI) (http://www.psi.ch/). The motivated candidate will also pursue opportunities to spend at least one year of the PhD at The University of Sydney. The applicant should have a recent master degree in Engineering or a related field. Good skills in both spoken and written English are mandatory to work in an international, young and dynamic team. Knowledge in Bioimaging, Signal Processing, Biomechanics and/or Bioengineering is an advantage. The position is available upon March 2011 or upon mutual agreement. Salaries are highly competitive and are in line with the guidelines of ETH Zurich.

A curriculum vitae, a list of two references and a transcript of all university classes attended (including grades) as well as a one-page statement of your background and research interest should be sent to (preferably by email):

Dr. Philipp Schneider
Institute for Biomechanics
ETH Zurich, Wolfgang-Pauli-Strasse 10, 8093 Zurich, Switzerland
Web: http://www.biomech.ethz.ch/
Email: pschneider@ethz.ch


Project description

Fracture repair is a hot topic for advancement due to clinical need. With recent advances in genetics and new pharmacological treatments there is a strong need for new techniques and methods to facilitate biological quantification for structure-function assessment in skeletal repair research. There, a number of new microstructural imaging modalities have been put forward allowing phenotypic quantification with high precision and accuracy in humans and animals, especially in the mouse. In the Institute for Biomechanics at ETH Zurich, new strategies for quantitative 3D bioimaging are investigated. Micro-computed tomography (ÁCT) is such an approach used to image and quantify bone in three dimensions (3D) providing resolutions ranging from a few millimeters down to one hundred nanometers. Recently, a synchrotron radiation-based computed tomography (SR CT) station has been designed and implemented at the Swiss Light Source (SLS) of the Paul Scherrer Institut (PSI) allowing 3D and fully nondestructive access to the ultrastructure of biological materials. Moreover, composition and material properties of bone tissue are investigated via internal ETH collaboration using other techniques such as Raman spectroscopy and nanoindentation. These technologies will be further developed to quantify bone healing in normal, pathological and pharmacologically treated models of bone repair.

This project has the following aims:

Develop new methods for quantitative phenotyping of fracture repair in bone tissue, using ÁCT, SR CT, Raman spectroscopy, and nanoindentation. Apply these newly developed methods for examining fracture repair in normal, pathological, and treated bone.
Develop and establish image-guided failure assessment (IGFA) for the investigation of microscopic failure behavior of normal, pathological, and treated bone, using SR CT.