View Full Version : PhD Candidate Position (AIO) in the Orthopaedic Biomechanics Group at TU/eindhoven

03-28-2011, 03:44 PM
The Eindhoven University of Technology, department of Biomedical Engineering has a vacancy for

PhD Student “Development of a mechanobiological model for the prediction of tissue remodeling after lumbar spine treatment” (V50.1328)

The Department of Biomedical Engineering is a joint department of the Eindhoven University of Technology and the University of Maastricht interfacing and integrating engineering and biomedical sciences from the two universities. The department is organized into 4 divisions: 1) molecular bioengineering, 2) biomechanics and tissue engineering, 3) biomedical imaging and informatics, and 4) biosignals and regulation. In the second division is the Orthopedic Biomechanics Section whose general objective is to improve our understanding of function and damage of orthopedic tissues, esp. bone, cartilage and intervertebral disc. Ultimately, these insights are used to develop and improve strategies for treatment of pathologies. For this purpose, we regularly combine experimental and computational approaches. Results from experimental studies on cells and/or tissues are captured in theories that are evaluated using computer models, and predictions by these models are helpful for the design and interpretation of further experiments.

Project description
Background: About 25% of the active EU population suffers from low back pain at some point in their lives. Surgery leads to satisfactory short-term pain relief, but long/mid-term outcomes are less positive in terms of progressive degeneration and pain recurrence. A EU consortium was formed to create a clinical tool to help predict the outcomes of lumbar spine treatments based on patient-specific biomechanical and mechanobiological rationales. The task of the Eindhoven group will be to adapt our current osmoporovisco-elastic disc model to that of a degenerated disc and to incorporate mechanobiological and nutrient adaptive effects. A full adaptive spinal motion segment model will be built by combining the disc model with another model of vertebral bone adaptation. Another challenge will be to make this model patient-specific by working with consortium partners to assess model parameter values from clinically assessable evaluation.

We are seeking a candidate facile with computational analysis and knowledgeable of biological processes. The candidate should be recently graduated from a MSc. program in biomedical engineering, mechanical engineering, (bio)physics or a related field, with,
• Knowledge and experience in biomedical science and technology,
• Strong affinity for multidisciplinary research and engineering science,
• Experience with finite element modeling and ex vivo biomechanical testing,
• Capacity to write and communicate fluently in English.

Appointment and Salary
We offer:
• a challenging job at a dynamic and ambitious University
• an appointment for four years
• gross monthly salaries are in accordance with the Collective Labor Agreement of the Dutch Universities (CAO NU), increasing from € 2042 per month initially, to € 2612 in the fourth year.
• an attractive package of fringe benefits (including excellent work facilities, child care and sport facilities)

The project will be supervised by dr. Bert van Rietbergen and Prof. dr. K. Ito (email k.ito@tue.nl, tel +31.40.2473851). More personnel information can be obtained from Y. Bloemers-Kluijtmans, personnel dept. (email: y.bloemers@tue.nl, tel +