View Full Version : muscle cell mechanics

unknown user
02-06-1997, 02:00 AM
Dear Biomch-l readers,

In order to study the aetiology of pressure sores we (dept. of Computational
and Experimental Mechanics, Eindhoven University of Technology & dept. of
Human Movement Sciences, Maastricht University) are developing a numerical
model and an animal model to obtain knowledge about the basic mechanisms
whereby 'external' mechanical loads (i.e. applied to the skin) result in soft
tissue degeneration, especially muscle tissue degeneration.

In addition, I am involved in the development and characterization of an
'in-vitro' model to study muscle cell deformation and damage as a consequence
of compressive loading. For this purpose I would like to compress cultured
myotubes in agarose gel and visualize them by (confocal) microscopy.
This technique is used before in other cells, but little information is
available about muscle cells in agarose and/or under compression.
I would like to knnow if someone has experience with this kind of research
or has information about muscle cells or muscle tissue under compression.

Thanking you in advance,

Carlijn Bouten
Eindhoven University of Technology
The Netherlands