View Full Version : PhD place avalaible

Liz Tanner
10-12-1999, 05:28 AM
Could this PhD place please be advertised on Biomech-L. I am sorry it is UK
residents only, but this is funded by a UK rsearch Council they put this

PhD Place available

The IRC in Biomedical Materials of the University of London has one
unfilled PhD place and is looking for a Materials Scientist/Mechanical
Engineer to fill the PhD studentship. This studentship will be based at
Queen Mary and Westfield College.

Background to Project
HAPEX, hydroxyapatite polyethylene composite, has been developed as a bone
replacement material. The mixture of hydroxyapatite and polyethylene means
that the stiffness approaches that of bone, but the lack of internal
organisation, unlike bone, means that the strength is less than that of
bone. The initial clinical use in the late 1980s was in the orbital floor,
both for patients who had lost their orbit and subsequently volume in the
orbital socket and for fractures of the orbital floor, good clinical
results were found (Downes et al., 1991). More recently HAPEX has been
commercialised by Smith & Nephew in the shaft of middle ear implants of a
range of designs (Bonfield & Tanner, 1997). Thus the designs which have
been used are low load bearing, but require the ability of HAPEX to
encourage bone to grow up to it. There are additional devices which are
minor load bearing which could use the combination of biological and
mechanical properties of HAPEX. Additionally, HAPEX has been
hydrostatically extruded at the IRC in Polymer Science at Leeds University,
which increases the stiffness by a factor of two and the strength by a
factor of four. This gives material which can be used in medium load
bearing applications.
The aim of this PhD would be to assess new areas where HAPEX could be used
clinically and then design and manufacture prototypes. The techniques
gained by the student would be designing, finite element analysis to
analysis the stresses on the implants and its supporting bone to ensure
that the implant does not fail or loosen in the bone, compression and
possibly injection moulding. Extensive mechanical test data including the
fatigue and creep behaviour of HAPEX is available. The biological response
to HAPEX has been, and continues to be, assessed and has been found to be
excellent with bone quickly growing upto the material.

Bonfield, W. & Tanner, K.E. (1997) Biomaterials - a New Generation,
Materials World, Vol 5, pp. 18-20.
Downes, R.N., Vardy, S., Tanner, K.E. & Bonfield, W. (1991)
Hydroxyapatite-Polyethylene Composite in Ophthalmic Surgery, In
"Bioceramics 4 - Proceedings of the Fourth International Symposium on
Ceramics in Medicine" Ed by W. Bonfield, G.W. Hastings and K.E. Tanner, Pub
Butterworth-Heinnemann Ltd pp. 239-246.
Revell, P.A., Tanner, K.E. & Freeman, M.A.R. (1996) Comparison of Bone
Graft and Bioactive Bone Substitutes in Promoting Bone Growth into
Implants, in "Bioceramics 9 - Proceedings of the Ninth International
Symposium on Ceramics in Medicine" Ed T. Kokubo, T. Nakamura and F. Mayaji,
Pub Pergamon, pp.193-196.
Tanner, K.E., Davies, G.W. & Bonfield, W. (1998) Processing HAPEX to near
Net Shape, in"Ceramics-Polymer Composites" Ed A. Ravaglioli and A.
Krajewski, Pub IRTEC-CNR, Italy, pp 85-90.

The grant is funded by the UK Engineering and Physical Sciences Research
Council so funding is only avalaible for a UK resident. The minimum
academic requirements are either a 2.1 or a 2.2 with an MSc.

For further details contact Prof Liz Tanner (K.E.Tanner@qmw.ac.uk). Further
information on the IRC in Biomedical Materials can be found at

================================================== ========================
Professor K.E. Tanner
Dean of Engineering and Professor of Biomedical Materials
IRC in Biomedical Materials and Department of Materials
Queen Mary and Westfield College
Mile End Road
E1 4NS

phone national 020 7882 5318 international +44-20-7882-5318
fax national 020 8983 1799 international +44-20-8983-1799
e-mail K.E.Tanner@qmw.ac.uk
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