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To Bone Researchers in the NYC area:
The second NYC mineralized tissue seminar of the Spring 2002
series will be on Thursday night, February 21st. The speaker is
Yixian Qin, Ph.D., Assistant Professor of Biomedical Engineering,
State University of New York, Stony Brook, NY. He will speak on FLUID
FLOW STIMULATES THE FORMATION OF BONE AS DEPENDENT ON TRANSCORTICAL
FLUID PRESSURE GRADIENTS. An abstract of this talk and a description
of Yixian's research interests are given below. The same information
on the other spring seminar speakers will soon be posted on
www.bonenet.net.
February 21, 2002 in room C197 at the CUNY Graduate Center at 7 PM.
Speaker: Yixian Qin, Ph.D., Assistant Professor of Biomedical
Engineering, SUNY Stony Brook
Title: FLUID FLOW STIMULATES THE FORMATION OF BONE AS DEPENDENT ON
TRANSCORTICAL FLUID PRESSURE GRADIENTS
Abstract: Considering the strong anabolic potential of mechanical
stimuli, and the devastating consequences of removing these
regulatory signals, it becomes critical to determine how the bone
cell population perceives subtle changes in their functional
environment. Indeed, improving our understanding of the manner in
which mechanical signals influence the temporal and spatial dynamics
of bone remodeling may help to devise a biomechanically based
intervention for treating osteoporosis, accelerating fracture healing
or promoting bony ingrowth into prostheses. The motion of
interstitial fluid within bone, which arises as a result of
functional load bearing, is hypothesized to be a critical mediator in
the perception and response of skeletal tissue to mechanical stimuli.
However, little is known about the remodeling responses that occur
during in vivo fluid flow stimuli in the absence of matrix
deformation. In particular, how bone-remodeling response to specific
mechanical fluid parameters is unknown. Our recent studies of bone
remodeling and formation demonstrate a strong correlation between the
fluid pressure gradient and the surface new bone formation. Fluid
flow applied at physiological level not only inhibits disuse induced
bone resorption, but also, dose-dependently, encourage bone formation
while applied in dynamic frequency. These results can also extend to
the trabecular region which low magnitude of fluid pressure and/or
surface fluid shear stress can initiate sufficient adaptive response
in trabeculae without matrix strain. The results suggest that the
fluid flow, which arises by functional loading, is an important
mediator in retaining bone quality and quantity, and that small
fluctuations in fluid flow, achieved via pressure differentials, has
potential for therapeutic applications against skeletal disorders
even in the absence of mechanical strain.
RESEARCH INTERESTS OF YIXIAN QIN: Major research efforts in tissue
remodeling and non-invasive assessment of bone physiology and
quality, with emphasis on understanding fluid flow mechanism in
skeletal tissues, and mechanotransduction of physical stimuli.
Related areas of interest extend to diagnostics of skeletal tissue
quality, including osteoporosis, space osteopenia and fracture
healing.
THE MARCH SEMINAR:
March 14th, 2002 in room 9207 at the CUNY Graduate Center at 7 PM.
Speaker: Professor Peter S. Walker PhD, Director of Biomedical
Engineering, Cooper
Union. Honorary/Research Professor, University College London;
University of Nebraska, Omaha; New York University.
Title: PROSPECTS FOR THE FUTURE OF TOTAL KNEE REPLACEMENT.
Abstract: The lecture discusses the evolution of TKR designs up to
this time. Follow up shows survivorship of 95% and better at ten
years. Using this as a solid base, there are now new challenges that
translate into design goals. How can the consistency of the surgery
be improved? How can higher flexion angles be achieved to accommodate
a full lifestyle? How can the time of surgery be minimized? How can
the rehabilitation time be reduced? The potential solutions and
progress so far to these design goals will be discussed.
RESEARCH INTERESTS OF PETER S. WALKER: TKR Design, Joint
Biomechanics, Minimally Invasive Surgery, Joint Resurfacing, Knee
Simulating Machines.
SPECIAL EVENT
THE MICROSCOPE AND THE SKELETON: A DIGITAL PHOTOMICROGRAPHY OF HARD TISSUES
Exhibition Dates: February 19 - March 16, 2002
Where: Bertha and Karl Leubsdorf Art Gallery
HUNTER COLLEGE
SW corner of 68th Street and Lexington Avenue, New York
Opening Reception: Tuesday, February 19, 5:30-7:30 p.m.
Gallery Hours: Monday - Saturday, 12-6 p.m.
Admission: Free and open to the public
WHERE AND WHEN: The seminar series is to be held this Spring in room
C197 (except for the March seminar which will be in Room 9207) at the
City University of New York (CUNY) Graduate Center (GC) on Thursdays
from 7 to 8:30 PM. The room C197 is in the concourse in the cellar).
There will be some socializing before the seminar in the GC snack bar
on the first floor, the 365 Express.
TRAVEL TO THE CITY UNIVERSITY OF NEW YORK (CUNY) GRADUATE CENTER (GC)
The Graduate Center (GC) of the City University of New York
(CUNY) is located in the newly renovated Altman Building at 365 5th
Avenue. The Altman Building occupies a city block bounded by 35th and
34th street on the north and south, respectively, and by Madison
Avenue and 5th Avenue and on the east and west, respectively. The
Altman Building is catty-corner from the Empire State Building. The
GC shares this building with the Science Division of the New York
Public Library and Oxford University Press. The entrance to the GC is
on 5th Avenue between, and almost equidistant from, East 34th Street
and East 35th Street.
The Pennsylvania Station (Amtrak, LLRR and New Jersey
Transit) is between 31st street and 33rd street on 7th Avenue. Grand
Central Station (Metro North) is on 42nd Street at Park Avenue. Park
Avenue is two blocks east of 5th Avenue (Madison is in between). Both
of these main line stations are short walks from the GC. The PATH
trains to New Jersey have a station at 34th Street and 6th Avenue.
There is also a heliport at 34th Street and East river, 6 avenue
blocks to the east.
Almost all the Manhattan subway lines have a station on 34th
Street and within several avenue blocks of the GC. There are a number
of bus lines that run on 34th street and on 5th Avenue. There are a
number of parking garages around the GC. There is money to support
parking for interested students, apply to Steve Cowin
(scccc@cunyvm.cuny,edu).
THE LOCATION OF THE BONE SEMINAR ACTIVITIES WITHIN THE GRADUATE CENTER (GC)
When you enter the GC from 5th Avenue there is a reception
counter in the center of a reception room and the elevators are
straight ahead. If you arrive at the GC with a few minutes to spare
before 7 PM you should consider stopping at the 365 Express on the
1st floor for sandwiches, snacks and drinks and to socialize with the
other seminar attendees and the evening's speaker. The 365 Express is
directly off the GC reception room on the 1st floor (the room you
entered from the street), off the southeast corner of the room. Room
C197 is in the cellar concourse. (For the March seminar, Room 9207 is
on the 9th floor.)
CLOSING NOTES
Future seminars are posted on www.bonenet.net, a website dedicated to
research on the mechanosensory system in bone. (This website is
operational, but not fully developed and suggestions for further
development of the site would be appreciated.) You may request a
reminder for each seminar by sending an email to Steve Cowin
(scccc@cunyvm.cuny.edu).
We will welcome your attendance and hope that you will pass along
this information to interested colleagues. Please direct your
questions, requests for more information and feedback to me.
Kind regards, Steve Cowin
--
************************************
For bone research information, visit .
************************************
PREFERRED MAILING ADDRESS
Stephen C. Cowin
2166 Broadway
Apartment 12D
New York, NY 10024
Phone (212) 799-7970 (Office at Home)
Fax (212) 799-7970 (Office at Home)
Phone (212) 650-5208 (Work)
Fax (212) 650-6727 (Work)
Email
WORK ADDRESS:
Stephen C. Cowin
Director, New York Center for Biomedical Engineering
School of Engineering
The City College
138th Street and Convent Avenue
New York, NY 10031-9198, U. S. A.
*************************************
For information about the New York Center for Biomedical
Engineering visit
*************************************
---------------------------------------------------------------
To unsubscribe send SIGNOFF BIOMCH-L to LISTSERV@nic.surfnet.nl
For information and archives: http://isb.ri.ccf.org/biomch-l
---------------------------------------------------------------
The second NYC mineralized tissue seminar of the Spring 2002
series will be on Thursday night, February 21st. The speaker is
Yixian Qin, Ph.D., Assistant Professor of Biomedical Engineering,
State University of New York, Stony Brook, NY. He will speak on FLUID
FLOW STIMULATES THE FORMATION OF BONE AS DEPENDENT ON TRANSCORTICAL
FLUID PRESSURE GRADIENTS. An abstract of this talk and a description
of Yixian's research interests are given below. The same information
on the other spring seminar speakers will soon be posted on
www.bonenet.net.
February 21, 2002 in room C197 at the CUNY Graduate Center at 7 PM.
Speaker: Yixian Qin, Ph.D., Assistant Professor of Biomedical
Engineering, SUNY Stony Brook
Title: FLUID FLOW STIMULATES THE FORMATION OF BONE AS DEPENDENT ON
TRANSCORTICAL FLUID PRESSURE GRADIENTS
Abstract: Considering the strong anabolic potential of mechanical
stimuli, and the devastating consequences of removing these
regulatory signals, it becomes critical to determine how the bone
cell population perceives subtle changes in their functional
environment. Indeed, improving our understanding of the manner in
which mechanical signals influence the temporal and spatial dynamics
of bone remodeling may help to devise a biomechanically based
intervention for treating osteoporosis, accelerating fracture healing
or promoting bony ingrowth into prostheses. The motion of
interstitial fluid within bone, which arises as a result of
functional load bearing, is hypothesized to be a critical mediator in
the perception and response of skeletal tissue to mechanical stimuli.
However, little is known about the remodeling responses that occur
during in vivo fluid flow stimuli in the absence of matrix
deformation. In particular, how bone-remodeling response to specific
mechanical fluid parameters is unknown. Our recent studies of bone
remodeling and formation demonstrate a strong correlation between the
fluid pressure gradient and the surface new bone formation. Fluid
flow applied at physiological level not only inhibits disuse induced
bone resorption, but also, dose-dependently, encourage bone formation
while applied in dynamic frequency. These results can also extend to
the trabecular region which low magnitude of fluid pressure and/or
surface fluid shear stress can initiate sufficient adaptive response
in trabeculae without matrix strain. The results suggest that the
fluid flow, which arises by functional loading, is an important
mediator in retaining bone quality and quantity, and that small
fluctuations in fluid flow, achieved via pressure differentials, has
potential for therapeutic applications against skeletal disorders
even in the absence of mechanical strain.
RESEARCH INTERESTS OF YIXIAN QIN: Major research efforts in tissue
remodeling and non-invasive assessment of bone physiology and
quality, with emphasis on understanding fluid flow mechanism in
skeletal tissues, and mechanotransduction of physical stimuli.
Related areas of interest extend to diagnostics of skeletal tissue
quality, including osteoporosis, space osteopenia and fracture
healing.
THE MARCH SEMINAR:
March 14th, 2002 in room 9207 at the CUNY Graduate Center at 7 PM.
Speaker: Professor Peter S. Walker PhD, Director of Biomedical
Engineering, Cooper
Union. Honorary/Research Professor, University College London;
University of Nebraska, Omaha; New York University.
Title: PROSPECTS FOR THE FUTURE OF TOTAL KNEE REPLACEMENT.
Abstract: The lecture discusses the evolution of TKR designs up to
this time. Follow up shows survivorship of 95% and better at ten
years. Using this as a solid base, there are now new challenges that
translate into design goals. How can the consistency of the surgery
be improved? How can higher flexion angles be achieved to accommodate
a full lifestyle? How can the time of surgery be minimized? How can
the rehabilitation time be reduced? The potential solutions and
progress so far to these design goals will be discussed.
RESEARCH INTERESTS OF PETER S. WALKER: TKR Design, Joint
Biomechanics, Minimally Invasive Surgery, Joint Resurfacing, Knee
Simulating Machines.
SPECIAL EVENT
THE MICROSCOPE AND THE SKELETON: A DIGITAL PHOTOMICROGRAPHY OF HARD TISSUES
Exhibition Dates: February 19 - March 16, 2002
Where: Bertha and Karl Leubsdorf Art Gallery
HUNTER COLLEGE
SW corner of 68th Street and Lexington Avenue, New York
Opening Reception: Tuesday, February 19, 5:30-7:30 p.m.
Gallery Hours: Monday - Saturday, 12-6 p.m.
Admission: Free and open to the public
WHERE AND WHEN: The seminar series is to be held this Spring in room
C197 (except for the March seminar which will be in Room 9207) at the
City University of New York (CUNY) Graduate Center (GC) on Thursdays
from 7 to 8:30 PM. The room C197 is in the concourse in the cellar).
There will be some socializing before the seminar in the GC snack bar
on the first floor, the 365 Express.
TRAVEL TO THE CITY UNIVERSITY OF NEW YORK (CUNY) GRADUATE CENTER (GC)
The Graduate Center (GC) of the City University of New York
(CUNY) is located in the newly renovated Altman Building at 365 5th
Avenue. The Altman Building occupies a city block bounded by 35th and
34th street on the north and south, respectively, and by Madison
Avenue and 5th Avenue and on the east and west, respectively. The
Altman Building is catty-corner from the Empire State Building. The
GC shares this building with the Science Division of the New York
Public Library and Oxford University Press. The entrance to the GC is
on 5th Avenue between, and almost equidistant from, East 34th Street
and East 35th Street.
The Pennsylvania Station (Amtrak, LLRR and New Jersey
Transit) is between 31st street and 33rd street on 7th Avenue. Grand
Central Station (Metro North) is on 42nd Street at Park Avenue. Park
Avenue is two blocks east of 5th Avenue (Madison is in between). Both
of these main line stations are short walks from the GC. The PATH
trains to New Jersey have a station at 34th Street and 6th Avenue.
There is also a heliport at 34th Street and East river, 6 avenue
blocks to the east.
Almost all the Manhattan subway lines have a station on 34th
Street and within several avenue blocks of the GC. There are a number
of bus lines that run on 34th street and on 5th Avenue. There are a
number of parking garages around the GC. There is money to support
parking for interested students, apply to Steve Cowin
(scccc@cunyvm.cuny,edu).
THE LOCATION OF THE BONE SEMINAR ACTIVITIES WITHIN THE GRADUATE CENTER (GC)
When you enter the GC from 5th Avenue there is a reception
counter in the center of a reception room and the elevators are
straight ahead. If you arrive at the GC with a few minutes to spare
before 7 PM you should consider stopping at the 365 Express on the
1st floor for sandwiches, snacks and drinks and to socialize with the
other seminar attendees and the evening's speaker. The 365 Express is
directly off the GC reception room on the 1st floor (the room you
entered from the street), off the southeast corner of the room. Room
C197 is in the cellar concourse. (For the March seminar, Room 9207 is
on the 9th floor.)
CLOSING NOTES
Future seminars are posted on www.bonenet.net, a website dedicated to
research on the mechanosensory system in bone. (This website is
operational, but not fully developed and suggestions for further
development of the site would be appreciated.) You may request a
reminder for each seminar by sending an email to Steve Cowin
(scccc@cunyvm.cuny.edu).
We will welcome your attendance and hope that you will pass along
this information to interested colleagues. Please direct your
questions, requests for more information and feedback to me.
Kind regards, Steve Cowin
--
************************************
For bone research information, visit .
************************************
PREFERRED MAILING ADDRESS
Stephen C. Cowin
2166 Broadway
Apartment 12D
New York, NY 10024
Phone (212) 799-7970 (Office at Home)
Fax (212) 799-7970 (Office at Home)
Phone (212) 650-5208 (Work)
Fax (212) 650-6727 (Work)
WORK ADDRESS:
Stephen C. Cowin
Director, New York Center for Biomedical Engineering
School of Engineering
The City College
138th Street and Convent Avenue
New York, NY 10031-9198, U. S. A.
*************************************
For information about the New York Center for Biomedical
Engineering visit
*************************************
---------------------------------------------------------------
To unsubscribe send SIGNOFF BIOMCH-L to LISTSERV@nic.surfnet.nl
For information and archives: http://isb.ri.ccf.org/biomch-l
---------------------------------------------------------------