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NYC Bone Seminar on April 10: Helen Lu on DESIGN CONSIDERATIONSIN ORTHOPEDIC TISSUE ENGINEERING OF BONE, SOFT TISSUE,AND INTERFACES

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  • NYC Bone Seminar on April 10: Helen Lu on DESIGN CONSIDERATIONSIN ORTHOPEDIC TISSUE ENGINEERING OF BONE, SOFT TISSUE,AND INTERFACES

    To Bone Researchers in the NYC area:
    The NYC Mineralized Tissue Seminar will have its second
    spring seminar on Thursday night April 10th in room C201 at the CUNY
    Graduate Center at 7 PM. The speaker is HELEN LU, Department of
    Biomedical Engineering, Columbia University. She will speak on DESIGN
    CONSIDERATIONS IN ORTHOPEDIC TISSUE ENGINEERING OF BONE, SOFT TISSUE,
    AND INTERFACES. An abstract for the seminar is below.
    The Bone Seminar Series has as its focus the mechanosensory system in
    bone. The series sponsors eight seminars a year beginning in
    September and continuing until April or May. The seminar program is
    regularly posted on www.bonenet.net, a website dedicated to research
    on the mechanosensory system in bone.

    XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX

    THE SPRING 2003 BONE SEMINAR PROGRAM

    The first three seminar series will be held in Room C201 (on the
    concourse level, below the ground floor) at the CUNY Graduate Center
    on Thursdays from 7 to 8:30 PM. The fourth seminar on June 5th will
    be held in Room 9204. The CUNY Graduate Center is in the Altman
    Building at the corner of 34th Street and 5th Avenue, catty-corner
    from the Empire State Building. There will be some socializing before
    the seminar in the seminar room from 5:45 PM. Also, from 5:45 PM
    until 7 PM there will be food (fruit plate, vegetable plate, cookies)
    and drink (coffee and soft drinks) available in the seminar room.
    There is also a Graduate Center snack bar on the first floor; besides
    the usual snacks and drinks the 365 Express also carries beer and
    wine.
    There are several subway lines nearby and it is less than a
    ten-minute walk to either Grand Central Station or Penn Station.
    There is money to support parking for graduate students, apply to
    Steve Cowin (contact information at the bottom).

    XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX

    APRIL 10th, 2003 in room C201 at the CUNY Graduate Center at 7 PM.

    Speaker: HELEN H. LU, PhD, Department of Biomedical Engineering,
    Columbia University.

    Title: DESIGN CONSIDERATIONS IN ORTHOPEDIC TISSUE ENGINEERING OF
    BONE, SOFT TISSUE, AND INTERFACES

    Abstract: Optimal treatment modalities in orthopedics are needed to
    meet the demands of an aging yet still active population. Due to
    limitations associated with existing biological and synthetic grafts,
    tissue engineering has emerged as an alternative approach in
    orthopedic repair and regeneration. An area of recent interest is
    the design of interfaces to facilitate the integration of bone with
    tissues such as muscle, cartilage, ligaments, and tendon. The nature
    of the tissue-tissue interface is important in the fixation of
    existing implants to bone, and in the integration of a variety of
    tissues formed in vitro using tissue engineering approaches.
    Development of a bone-soft tissue interface is a highly complex
    problem, involving the engineering of both soft and hard tissue, as
    well as the interfacial region. This talk will first describe our
    research efforts in bone tissue engineering utilizing a composite
    scaffold of biodegradable polymers and bioactive ceramics seeded with
    bone-forming cells, as well as the use of bone morphogenetic proteins
    in promoting mineralization by varied cell sources. Next, results
    from our work in tissue engineering of the anterior cruciate ligament
    using a three-dimensional, porous, biodegradable, and braided
    construct will be presented. The design, in vitro and in vivo
    characterizations, and optimization of both soft and hard tissue
    engineering constructs will be discussed. Finally, current efforts
    in the integration of soft and hard tissues will be described, and
    new research directions will be proposed.
    RESEARCH INTERESTS OF HELEN LU: Dr. Lu's research focuses on the
    regeneration of a functional interface between bone and
    ligaments/tendons, as well as the interface connecting bone and
    cartilage. Providing a mechanically functional interface between the
    biomaterial and bone tissue, and between bone and soft tissue will
    significantly improve the long-term stability of the implant. Dr.
    Lu's research group at the Biomaterials and Interface Tissue
    Engineering Laboratory at Columbia University are developing in vitro
    culturing systems to mimic the formation of the interface between
    bone and soft tissue (cartilage and ligament) in vivo. These systems
    are used to examine the effect of co-culturing on the growth and
    differentiation of osteoblasts, chondrocytes and ligament
    fibroblasts. Results from these studies are being utilized to design
    3-D, tissue engineered scaffold systems that can be applied in the
    treatment of osteoarthritis and anterior cruciate ligament injuries.

    XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX

    ORGANIZATION OF THE SEMINAR SERIES

    The Interinstitutional Steering Committee (ISC) will make decisions
    concerning the seminar series, including the selection of speakers.
    Interesting, high quality seminar speakers are sought. Seminar
    attendees are asked to help in the identification of investigators
    with new results relative to the bone research, questions of current
    interest and distinguished bone researchers visiting New York City
    who might be persuaded to present a seminar. Presentations by
    advanced graduate students and post-docs are encouraged.
    The members of the Interinstitutional Steering Committee (ISC) are
    Adele Boskey (Head of the Mineralized Tissue Section at the Hospital
    for Special Surgery and Professor of Biochemistry at the Weill
    Medical College of Cornell University), Timothy Bromage (Director of
    the Hard Tissue Research Unit and Professor of Anthropology at Hunter
    College of CUNY), Stephen C. Cowin (Director of the New York Center
    for Biomedical Engineering (NYCBE) and Professor of Biomedical and
    Mechanical Engineering at the City College of the City University of
    New York (CUNY)), Susannah P. Fritton (Director of the Tissue
    Mechanics Laboratory, New York Center for Biomedical Engineering and
    Associate Professor of Biomedical Engineering at the City College of
    CUNY), X. Edward Guo (Director of the Bone Bioengineering Laboratory
    and Assistant Professor of Bioengineering at Columbia University),
    Clinton T. Rubin (Professor and Chair of the Department of Biomedical
    Engineering, and Director of the Center for Advanced Technology in
    Medical Biotechnology at SUNY Stony Brook) and Mitchell B. Schaffler
    (Director of Orthopaedic Research and Professor of Orthopedics, Cell
    Biology and Anatomy at the Mount Sinai School of Medicine). Each of
    these people represents a community consisting of senior bone
    research people, graduate students and, in most cases, undergraduate
    students.

    PLEASE DIRECT YOUR QUESTIONS AND FEEDBACK TO

    Stephen C. Cowin
    Director, New York Center for Biomedical Engineering
    School of Engineering
    The City College
    138th Street and Convent Avenue
    New York, NY 10031-9198, U. S. A.

    Phone (212) 799-7970 (Office at Home)
    Fax (212) 799-7970 (Office at Home)
    Phone (212) 650-5208 (Work)
    Email

    --

    ************************************
    For bone research information, visit .
    ************************************
    PREFERRED MAILING ADDRESS
    Stephen C. Cowin
    2166 Broadway
    Apartment 12D
    New York, NY 10024

    Phone (212) 799-7970 (Office at Home)
    Fax (212) 799-7970 (Office at Home)
    Phone (212) 650-5208 (Work)
    Fax (212) 650-6727 (Work)
    Email

    WORK ADDRESS:
    Stephen C. Cowin
    Director, New York Center for Biomedical Engineering
    School of Engineering
    The City College
    138th Street and Convent Avenue
    New York, NY 10031-9198, U. S. A.
    *************************************
    For information about the New York Center for Biomedical
    Engineering visit
    *************************************

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