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BIOIMAGING AND BIOMECHANICS IN TISSUE ENGINEERING APPLICATIONS OF BONE REPAIR
Institute for Biomedical Engineering
Swiss Federal Institute of Technology (ETH) and University of Zürich
Tackling osteoporosis in a rapidly aging population is an increasing priority world-wide.
Loss of bone density results from a shift in the equilibrium between bone formation and
resorption in favor of resorption. The presence of osteoporosis, found predominantly in
the elderly, leaves the patient with a high incidence of fractures and reduces the
potential for repair. Ultimately, osteoporosis leads to reduced quality of life with
significant pain and morbidity. Novel materials, based on injectable fibrin scaffold
technologies, have recently been developed by an industry partner for orthopedic
applications. These scaffolds offer a new technique which can deliver active factors in a
highly controlled manner to localized areas in osteoporotic bone. This type of approach
offers exciting prospects for bone tissue engineering, repair of defects, enhancing bone
density, and improved implant fixation in bone weakened by osteoporosis and age-related
bone loss.
The project will focus initially on the analysis of materials in animal models which
closely reflect the clinical situation. In addition, we will establish new and accurate,
analytical methods based on micro-computed tomography (uCT) for 3D imaging of bone as well
as biomechanical testing. Using these techniques we will study the repair process in both
animals and humans together with the materials in situ. The position will facilitate
collaboration between the industry and academic partner with the potential to drive the
project through pre-clinical and clinical phases. The post will come with responsibilities
including sourcing necessary materials, coordinating and assisting with animal
experiments, development of uCT protocols and biomechanical testing as well as finding
correlations amongst the data. Subsequently, this scientist may be responsible for
building cooperation with surgeons together with planning and implementing clinical
studies.
We are looking for a highly motivated, creative and independently working person with a
doctoral degree in either Electrical, Mechanical or Biomedical Engineering. An in-depth
training in bioimaging and/or biomechanics is absolutely required. Applicant must have
good skills in spoken and written English to work in an international, young and dynamic
team. Knowledge of German as well as a background in biology or biomedical engineering is
an advantage.
The project is funded through the Swiss Commission of Technology and Innovation and is
part of a collaboration with Kuros Biosurgery (www.kuros.ch), a University spin-off
company located in Zürich which mission is to develop commercially successful therapies
for biosurgery, tissue repair and regeneration. The position is available immediately and
is initially for two years. Salaries are highly competitive and in accordance with the
guidelines of the Swiss Federal Institute of Technology.
A letter of application, a statement of research interests, a complete curriculum vitae
including university transcripts, and a list of three references should be sent to
(preferably by email):
Prof. Ralph Müller, Ph.D.
Institute for Biomedical Engineering
Swiss Federal Institute of Technology and University of Zürich
Moussonstrasse 18, 8044 Zürich, Switzerland
Email: ralph.mueller@biomed.ee.ethz.ch
Web: http://www.bioelectronics.ethz.ch/
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Institute for Biomedical Engineering
Swiss Federal Institute of Technology (ETH) and University of Zürich
Tackling osteoporosis in a rapidly aging population is an increasing priority world-wide.
Loss of bone density results from a shift in the equilibrium between bone formation and
resorption in favor of resorption. The presence of osteoporosis, found predominantly in
the elderly, leaves the patient with a high incidence of fractures and reduces the
potential for repair. Ultimately, osteoporosis leads to reduced quality of life with
significant pain and morbidity. Novel materials, based on injectable fibrin scaffold
technologies, have recently been developed by an industry partner for orthopedic
applications. These scaffolds offer a new technique which can deliver active factors in a
highly controlled manner to localized areas in osteoporotic bone. This type of approach
offers exciting prospects for bone tissue engineering, repair of defects, enhancing bone
density, and improved implant fixation in bone weakened by osteoporosis and age-related
bone loss.
The project will focus initially on the analysis of materials in animal models which
closely reflect the clinical situation. In addition, we will establish new and accurate,
analytical methods based on micro-computed tomography (uCT) for 3D imaging of bone as well
as biomechanical testing. Using these techniques we will study the repair process in both
animals and humans together with the materials in situ. The position will facilitate
collaboration between the industry and academic partner with the potential to drive the
project through pre-clinical and clinical phases. The post will come with responsibilities
including sourcing necessary materials, coordinating and assisting with animal
experiments, development of uCT protocols and biomechanical testing as well as finding
correlations amongst the data. Subsequently, this scientist may be responsible for
building cooperation with surgeons together with planning and implementing clinical
studies.
We are looking for a highly motivated, creative and independently working person with a
doctoral degree in either Electrical, Mechanical or Biomedical Engineering. An in-depth
training in bioimaging and/or biomechanics is absolutely required. Applicant must have
good skills in spoken and written English to work in an international, young and dynamic
team. Knowledge of German as well as a background in biology or biomedical engineering is
an advantage.
The project is funded through the Swiss Commission of Technology and Innovation and is
part of a collaboration with Kuros Biosurgery (www.kuros.ch), a University spin-off
company located in Zürich which mission is to develop commercially successful therapies
for biosurgery, tissue repair and regeneration. The position is available immediately and
is initially for two years. Salaries are highly competitive and in accordance with the
guidelines of the Swiss Federal Institute of Technology.
A letter of application, a statement of research interests, a complete curriculum vitae
including university transcripts, and a list of three references should be sent to
(preferably by email):
Prof. Ralph Müller, Ph.D.
Institute for Biomedical Engineering
Swiss Federal Institute of Technology and University of Zürich
Moussonstrasse 18, 8044 Zürich, Switzerland
Email: ralph.mueller@biomed.ee.ethz.ch
Web: http://www.bioelectronics.ethz.ch/
-----------------------------------------------------------------
To unsubscribe send SIGNOFF BIOMCH-L to LISTSERV@nic.surfnet.nl
For information and archives: http://isb.ri.ccf.org/biomch-l
Please consider posting your message to the Biomch-L Web-based
Discussion Forum: http://movement-analysis.com/biomch_l
-----------------------------------------------------------------