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Preparation of QCT Phantoms for Bone

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  • Preparation of QCT Phantoms for Bone

    I am currently conducting ultrasonic testing of small sections of cortical
    bone to map the elastic moduli of a canine radius for use in the
    construction of a finite element model. The calculations require values
    for the apparent (structural) density of the bone, which I am measuring
    simply by mass/volume of the bone specimens.

    I would like to compare the densities that I am using to densities obtained
    from an intact bone using quantitative CT data. But in order to do the
    QCT, I need to obtain or prepare phantoms for a complete range of
    densities--from 1.0 to 2.0 g/cm3. I have found reports (Genant et al.,
    1981; Ruff, 1986 of liquid phantom solutions containing dipotassium
    hydrogen phosphate (K2HPO4) and ethyl alcohol, but have found no
    description of the exact composition of these solutions. I am basically
    looking for a "cookbook recipe" to prepare suitable liquid phantoms.

    Other papers (Bentzen et al., 1987; Hvid et al., 1989) have reported the
    use of acrylic phantoms while more recent reports indicate the use of solid
    phantoms containing tricalcium phosphate and polymethyl methacrylate
    (Snyder and Schneider, 1991). These phantoms provide a range of density
    suitable for bone, but again only very brief mention is made of the
    materials.

    I would appreciate any information on the preparation of QCT phantoms and
    the determination of apparent density (not bone mineral density) of
    cortical bone using QCT methods. Any comments or suggestions on my
    approach would also be greatly appreciated.

    Thank you.

    John C. Coleman
    Department of Biomedical Engineering
    Tulane University
    New Orleans, LA 70118
    Phone: (504) 865-5897
    E-mail: johnc@bmen.tulane.edu
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