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NYC Bone Seminar - Spring 06 Series

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  • NYC Bone Seminar - Spring 06 Series

    Hi Folks:

    The Spring 2006 Bone Seminar Series begins on
    Tuesday, February 21 with a presentation by
    Racquel LeGeros, Ph.D., the L. Linkow Professor
    at the New York University College of Dentistry.
    She will speak on " Calcium Phosphate-Based
    Biomaterials: an Update."

    Details about the workshop and all seminars
    appear below as well as on our website:
    http://bonenet.net

    The contents of the rest of this email are as follows:
    [1] Bone Seminar Series: General Information
    [2] February 21, 2006 Seminar: Racquel LeGeros, Ph.D.; Host: Tim Bromage
    [3] March 14, 2006 Seminar: Chris Price, Ph.D. candidate Host: Bob Majeska
    [4] April 11, 2006 Seminar: Jeremy Mao, DDS, Ph.D. Host: Ed Guo
    [5] May 9, 2006 Seminar: Tony Valdevit, Host: Peter Walker

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    THE SPRING 2006 BONE SEMINAR SERIES

    The Bone Seminar Series has as its focus the
    mechanosensory system in bone. Seminar program
    and workshop information are regularly posted on
    www.bonenet.net, a website dedicated to research
    on the mechanosensory system in bone. Please send
    comments on the website to the webmaster, Bill
    Green or to me
    . Please let us have your
    comments.

    XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX

    THE SPRING 2006 BONE SEMINAR PROGRAM

    Seminars will be held on Tuesdays from 7:00 to
    about 8:30 PM in the rooms indicated in the CUNY
    Graduate Center at the corner of 34th Street and
    5th Avenue, catty-corner from the Empire State
    Building. There will be some socializing before
    the seminar in the seminar room from 5:45 PM.
    Also, from 5:45 PM until 7:00 PM there will be
    food (fruit plate, vegetable plate, cookies) and
    drink (coffee and soft drinks) available in the
    seminar room. There is also a Graduate Center
    snack bar on the first floor.
    There are several subway lines nearby, and it is
    less than a ten-minute walk to either Grand
    Central Station or Penn Station. There is money
    to support parking for graduate students; apply
    to Steve Cowin (contact information at the
    bottom).

    XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX

    February 21, 2006 in room C202 at the CUNY Graduate Center at 7:00 PM

    Speaker: Racquel LeGeros, Ph.D.; Professor and Associate Chair,
    Department of Biomaterials & Biomimetics,
    L. Linkow Professor in Implant Dentistry
    Director, Calcium Phosphate Research Laboratory
    New York University College of Dentistry

    Host: Tim Bromage

    Title: CALCIUM PHOSPHATE-BASED BIOMATERIALS: AN UPDATE

    Abstract: Bone is a composite of a mineral
    (carbonatehydroxyapatite, CHA) and a polymer
    (collagen). The rational for the use of CaP-based
    biomaterials is their similarity in composition
    to the bone mineral or bone apatite. In addition,
    CaP biomaterials have demonstrated bioactive,
    osteoconductive and sometimes, even
    osteoinductive properties - properties that make
    them superior to other types of biomaterials used
    for similar purposes.
    Commercial and experimental CaP-based
    biomaterials are of biologic (e.g., bovine-bone
    derived, coral-derived) and synthetic origin.
    These include: bioceramics {e.g., hydroxyapatite
    (HA), beta-tricalcium phosphate (-TCP), biphasic
    calcium phosphate (BCP) consisting of an intimate
    mixture of HA and -TCP, substituted apatite
    (e.g., F-containing apatite, FA and CFA),
    substituted -TCP (e.g., Mg-substituted o
    -TCMP)}, calcium phosphate cements (CPC, calcium
    phosphate glasses (CPG), CaP/polymer composites
    (HA/polyethylene, HA or CHA/collagen, HA or
    -TCP/PLGA), coatings (plasma-sprayed,
    electrochemically deposited or precipitated) on
    orthopedic and dental implants.
    Applications (current and potential) of CaP-based
    biomaterials in dentistry and medicine include:
    bone repair, bone substitution, bone
    augmentation, as scaffolds for tissue engineering
    for regeneration of teeth and bones, drug
    delivery, gene therapy and osteoporosis therapy.
    Our research relating to calcium phosphate
    biomaterials will be briefly reviewed.

    RESEARCH INTERESTS OF Racquel LeGeros: Calcium
    phosphates in biological systems; calcium
    phosphate based-biomaterials (scaffolds, implant
    coatings, cements, composites); calcium
    phosphates in osteoporosis therapy.

    XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX

    MARCH 14, 2006 in room C203 at the CUNY Graduate Center at 7:00 PM

    Speaker: Chris Price, Ph.D. candidate in
    Biomedical Sciences at the Graduate School of
    Biomedical Sciences, Mount Sinai School of
    Medicine; Orthopaedics Research Laboratory, Mount
    Sinai School of Medicine

    Host: Bob Majeska

    Title: GENETIC VARIABILITY IN SKELETAL GROWTH:
    HOW DOES BIOLOGY INFLUENCE FRACTURE RISK?

    Abstract: Osteoporotic fracture risk is
    functionally dependent on bone size and shape,
    and thus the processes of skeletal growth early
    in life and bone loss during aging. Whereas a
    large number of studies have focused on the role
    of bone loss in fracture, less is known about the
    role of skeletal growth and development on
    fracture risk. Studies have shown a strong
    connection between peak adult bone size and shape
    (i.e. robustness) and fracture risk later in
    life; furthermore this variability in skeletal
    robusticity is heritable. However, the biological
    mechanisms through which variability in genetics
    influences adult bone morphology are largely
    unknown. Using both engineering and biological
    based approaches our lab has begun to
    systematically establish the functional
    connections between genetic background, the
    biological control of skeletal growth, and peak
    bone properties. Based on these strategies we
    hope to develop new ways of identifying and
    predicting fracture risk early in life, and
    establishing novel prevention and treatment
    regimens. To advance this goal we are utilizing
    an inbred mouse model of skeletal growth and
    biomechanics to connect genetic variability to
    differences in whole bone phenotypes. In these
    inbred mice we have demonstrated that variability
    in transverse femoral growth patterns (from birth
    to 1 year of age) play an important role in
    establishing femoral robusticity. Our research
    demonstrated that inbred mice create very
    different, yet functional, adult femurs based
    upon genotype-specific variability in the general
    patterns of long bone growth (i.e. periosteal and
    endosteal expansion/contraction) that are common
    to most mammalian species (including humans).
    Additionally, our data suggests that variability
    in femoral growth patterns may be functionally
    coupled to genetic variability in material
    quality/composition. Because all genetic
    influences on skeletal growth are necessarily
    propagated through the biological influences of
    the osteoblast and osteoclast upon the bones
    surfaces we are now currently investigating the
    role of bone cell behavior on growth pattern
    variability and adult bone trait outcomes.
    Together, our data provide us with a systematic
    and hierarchical approach to begin to close the
    large gap between genomic variability and whole
    bone fracture risk.

    RESEARCH INTERESTS OF CHRISTOPHER PRICE:
    Investigating the role of variability in skeletal
    growth and development on fracture risk;
    Development of novel phenotyping methods for use
    in skeletal health diagnosis and the genetic
    evaluation of fracture risk; Integrating advanced
    skeletal imaging techniques with novel approaches
    to standard bone analysis to dissect the genetic
    basis of skeletal disease.

    XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX

    APRIL 11, 2006 in room C202 at the CUNY Graduate Center at 7:00 PM

    Speaker: JEREMY MAO, DDS, PHD, School of Dental
    and Oral Surgery, Columbia University

    Title: MECHANICAL MODULATION OF CRANIOFACIAL GROWTH

    Abstract: Craniofacial skeleton is load bearing,
    but not weight bearing. Most of craniofacial
    skeleton is derived from neural crest cells. The
    magnitude of mechanical strain that is capable of
    eliciting bone modeling and remodeling responses
    in craniofacial skeleton appears small, in
    comparison to appendicular bones. Isolated
    craniofacial osteoblasts appear to respond to the
    same mechanical strain differently than
    appendicular osteoblasts. Most craniofacial
    bones lengthen by bone apposition in cranial
    sutures, as opposed to growth plates. Sutural
    cells appear to readily respond to mechanical
    stresses. Our understanding of craniofacial
    skeletal development, especially in response to
    mechanical stress, is far from complete.
    Nonetheless, significant insight has been gained
    in the past decade towards the understanding of
    mechanical modulation of craniofacial growth.

    RESEARCH INTERESTS OF JEREMY MAO: Craniofacial
    development, especially in response to mechanical
    stress. Tissue engineering by stem cells and
    biomaterials

    XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX


    May 9, 2006 in room C201 at the CUNY Graduate Center at 7:00 PM

    Speaker: TONY VALDEVIT,

    Host: Peter Walker

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    ORGANIZATION OF THE SEMINAR SERIES

    The Interinstitutional Steering Committee (ISC)
    will make decisions concerning the seminar
    series, including the selection of speakers.
    Interesting, high quality seminar speakers are
    sought. Seminar attendees are asked to help in
    the identification of investigators with new
    results relative to bone research, questions of
    current interest and distinguished bone
    researchers visiting New York City who might be
    persuaded to present a seminar. Presentations by
    advanced graduate students and post-docs are
    encouraged.
    The members of the Interinstitutional Steering
    Committee (ISC) are Adele Boskey (Head of the
    Mineralized Tissue Section at the Hospital for
    Special Surgery and Professor of Biochemistry at
    the Weill Medical College of Cornell University),
    Timothy Bromage (Director, Hard Tissue Research
    Unit, New York University College of Dentistry),
    Stephen C. Cowin (Professor of Biomedical and
    Mechanical Engineering at the City College of the
    City University of New York (CUNY)), Susannah P.
    Fritton (Director of the Tissue Mechanics
    Laboratory, New York Center for Biomedical
    Engineering and Associate Professor of Biomedical
    Engineering at the City College of CUNY), X.
    Edward Guo (Director of the Bone Bioengineering
    Laboratory and Associate Professor of
    Bioengineering at Columbia University), Clinton
    T. Rubin (Professor and Chair of the Department
    of Biomedical Engineering, and Director of the
    Center for Advanced Technology in Medical
    Biotechnology at SUNY Stony Brook) and Mitchell
    B. Schaffler (Director of Orthopaedic Research
    and Professor of Orthopedics, Cell Biology and
    Anatomy at the Mount Sinai School of Medicine).
    Each of these people represents a community
    consisting of senior bone research people,
    graduate students and, in most cases,
    undergraduate students.

    PLEASE DIRECT YOUR QUESTIONS AND FEEDBACK TO

    Stephen C. Cowin
    New York Center for Biomedical Engineering
    Departments of Biomedical and Mechanical Engineering
    School of Engineering
    The City College
    138th Street and Convent Avenue
    New York, NY 10031-9198, U. S. A.

    Phone (212) 799-7970 (Office at Home)
    Fax (212) 799-7970 (Office at Home)
    Phone (212) 650-5208 (Work)
    Email
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