Hi Folks:

The Spring 2006 Bone Seminar Series begins on
Tuesday, February 21 with a presentation by
Racquel LeGeros, Ph.D., the L. Linkow Professor
at the New York University College of Dentistry.
She will speak on " Calcium Phosphate-Based
Biomaterials: an Update."

Details about the workshop and all seminars
appear below as well as on our website:

The contents of the rest of this email are as follows:
[1] Bone Seminar Series: General Information
[2] February 21, 2006 Seminar: Racquel LeGeros, Ph.D.; Host: Tim Bromage
[3] March 14, 2006 Seminar: Chris Price, Ph.D. candidate Host: Bob Majeska
[4] April 11, 2006 Seminar: Jeremy Mao, DDS, Ph.D. Host: Ed Guo
[5] May 9, 2006 Seminar: Tony Valdevit, Host: Peter Walker


The Bone Seminar Series has as its focus the
mechanosensory system in bone. Seminar program
and workshop information are regularly posted on
www.bonenet.net, a website dedicated to research
on the mechanosensory system in bone. Please send
comments on the website to the webmaster, Bill
Green or to me
. Please let us have your



Seminars will be held on Tuesdays from 7:00 to
about 8:30 PM in the rooms indicated in the CUNY
Graduate Center at the corner of 34th Street and
5th Avenue, catty-corner from the Empire State
Building. There will be some socializing before
the seminar in the seminar room from 5:45 PM.
Also, from 5:45 PM until 7:00 PM there will be
food (fruit plate, vegetable plate, cookies) and
drink (coffee and soft drinks) available in the
seminar room. There is also a Graduate Center
snack bar on the first floor.
There are several subway lines nearby, and it is
less than a ten-minute walk to either Grand
Central Station or Penn Station. There is money
to support parking for graduate students; apply
to Steve Cowin (contact information at the


February 21, 2006 in room C202 at the CUNY Graduate Center at 7:00 PM

Speaker: Racquel LeGeros, Ph.D.; Professor and Associate Chair,
Department of Biomaterials & Biomimetics,
L. Linkow Professor in Implant Dentistry
Director, Calcium Phosphate Research Laboratory
New York University College of Dentistry

Host: Tim Bromage


Abstract: Bone is a composite of a mineral
(carbonatehydroxyapatite, CHA) and a polymer
(collagen). The rational for the use of CaP-based
biomaterials is their similarity in composition
to the bone mineral or bone apatite. In addition,
CaP biomaterials have demonstrated bioactive,
osteoconductive and sometimes, even
osteoinductive properties - properties that make
them superior to other types of biomaterials used
for similar purposes.
Commercial and experimental CaP-based
biomaterials are of biologic (e.g., bovine-bone
derived, coral-derived) and synthetic origin.
These include: bioceramics {e.g., hydroxyapatite
(HA), beta-tricalcium phosphate (-TCP), biphasic
calcium phosphate (BCP) consisting of an intimate
mixture of HA and -TCP, substituted apatite
(e.g., F-containing apatite, FA and CFA),
substituted -TCP (e.g., Mg-substituted o
-TCMP)}, calcium phosphate cements (CPC, calcium
phosphate glasses (CPG), CaP/polymer composites
(HA/polyethylene, HA or CHA/collagen, HA or
-TCP/PLGA), coatings (plasma-sprayed,
electrochemically deposited or precipitated) on
orthopedic and dental implants.
Applications (current and potential) of CaP-based
biomaterials in dentistry and medicine include:
bone repair, bone substitution, bone
augmentation, as scaffolds for tissue engineering
for regeneration of teeth and bones, drug
delivery, gene therapy and osteoporosis therapy.
Our research relating to calcium phosphate
biomaterials will be briefly reviewed.

RESEARCH INTERESTS OF Racquel LeGeros: Calcium
phosphates in biological systems; calcium
phosphate based-biomaterials (scaffolds, implant
coatings, cements, composites); calcium
phosphates in osteoporosis therapy.


MARCH 14, 2006 in room C203 at the CUNY Graduate Center at 7:00 PM

Speaker: Chris Price, Ph.D. candidate in
Biomedical Sciences at the Graduate School of
Biomedical Sciences, Mount Sinai School of
Medicine; Orthopaedics Research Laboratory, Mount
Sinai School of Medicine

Host: Bob Majeska


Abstract: Osteoporotic fracture risk is
functionally dependent on bone size and shape,
and thus the processes of skeletal growth early
in life and bone loss during aging. Whereas a
large number of studies have focused on the role
of bone loss in fracture, less is known about the
role of skeletal growth and development on
fracture risk. Studies have shown a strong
connection between peak adult bone size and shape
(i.e. robustness) and fracture risk later in
life; furthermore this variability in skeletal
robusticity is heritable. However, the biological
mechanisms through which variability in genetics
influences adult bone morphology are largely
unknown. Using both engineering and biological
based approaches our lab has begun to
systematically establish the functional
connections between genetic background, the
biological control of skeletal growth, and peak
bone properties. Based on these strategies we
hope to develop new ways of identifying and
predicting fracture risk early in life, and
establishing novel prevention and treatment
regimens. To advance this goal we are utilizing
an inbred mouse model of skeletal growth and
biomechanics to connect genetic variability to
differences in whole bone phenotypes. In these
inbred mice we have demonstrated that variability
in transverse femoral growth patterns (from birth
to 1 year of age) play an important role in
establishing femoral robusticity. Our research
demonstrated that inbred mice create very
different, yet functional, adult femurs based
upon genotype-specific variability in the general
patterns of long bone growth (i.e. periosteal and
endosteal expansion/contraction) that are common
to most mammalian species (including humans).
Additionally, our data suggests that variability
in femoral growth patterns may be functionally
coupled to genetic variability in material
quality/composition. Because all genetic
influences on skeletal growth are necessarily
propagated through the biological influences of
the osteoblast and osteoclast upon the bones
surfaces we are now currently investigating the
role of bone cell behavior on growth pattern
variability and adult bone trait outcomes.
Together, our data provide us with a systematic
and hierarchical approach to begin to close the
large gap between genomic variability and whole
bone fracture risk.

Investigating the role of variability in skeletal
growth and development on fracture risk;
Development of novel phenotyping methods for use
in skeletal health diagnosis and the genetic
evaluation of fracture risk; Integrating advanced
skeletal imaging techniques with novel approaches
to standard bone analysis to dissect the genetic
basis of skeletal disease.


APRIL 11, 2006 in room C202 at the CUNY Graduate Center at 7:00 PM

Speaker: JEREMY MAO, DDS, PHD, School of Dental
and Oral Surgery, Columbia University


Abstract: Craniofacial skeleton is load bearing,
but not weight bearing. Most of craniofacial
skeleton is derived from neural crest cells. The
magnitude of mechanical strain that is capable of
eliciting bone modeling and remodeling responses
in craniofacial skeleton appears small, in
comparison to appendicular bones. Isolated
craniofacial osteoblasts appear to respond to the
same mechanical strain differently than
appendicular osteoblasts. Most craniofacial
bones lengthen by bone apposition in cranial
sutures, as opposed to growth plates. Sutural
cells appear to readily respond to mechanical
stresses. Our understanding of craniofacial
skeletal development, especially in response to
mechanical stress, is far from complete.
Nonetheless, significant insight has been gained
in the past decade towards the understanding of
mechanical modulation of craniofacial growth.

development, especially in response to mechanical
stress. Tissue engineering by stem cells and


May 9, 2006 in room C201 at the CUNY Graduate Center at 7:00 PM


Host: Peter Walker



The Interinstitutional Steering Committee (ISC)
will make decisions concerning the seminar
series, including the selection of speakers.
Interesting, high quality seminar speakers are
sought. Seminar attendees are asked to help in
the identification of investigators with new
results relative to bone research, questions of
current interest and distinguished bone
researchers visiting New York City who might be
persuaded to present a seminar. Presentations by
advanced graduate students and post-docs are
The members of the Interinstitutional Steering
Committee (ISC) are Adele Boskey (Head of the
Mineralized Tissue Section at the Hospital for
Special Surgery and Professor of Biochemistry at
the Weill Medical College of Cornell University),
Timothy Bromage (Director, Hard Tissue Research
Unit, New York University College of Dentistry),
Stephen C. Cowin (Professor of Biomedical and
Mechanical Engineering at the City College of the
City University of New York (CUNY)), Susannah P.
Fritton (Director of the Tissue Mechanics
Laboratory, New York Center for Biomedical
Engineering and Associate Professor of Biomedical
Engineering at the City College of CUNY), X.
Edward Guo (Director of the Bone Bioengineering
Laboratory and Associate Professor of
Bioengineering at Columbia University), Clinton
T. Rubin (Professor and Chair of the Department
of Biomedical Engineering, and Director of the
Center for Advanced Technology in Medical
Biotechnology at SUNY Stony Brook) and Mitchell
B. Schaffler (Director of Orthopaedic Research
and Professor of Orthopedics, Cell Biology and
Anatomy at the Mount Sinai School of Medicine).
Each of these people represents a community
consisting of senior bone research people,
graduate students and, in most cases,
undergraduate students.


Stephen C. Cowin
New York Center for Biomedical Engineering
Departments of Biomedical and Mechanical Engineering
School of Engineering
The City College
138th Street and Convent Avenue
New York, NY 10031-9198, U. S. A.

Phone (212) 799-7970 (Office at Home)
Fax (212) 799-7970 (Office at Home)
Phone (212) 650-5208 (Work)