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  • - Formulation of current concepts in knee jointregeneration

    -- 2nd Announcement and Call for Abstracts --


    The Interaction of Mechanics and Biology in Knee Joint
    Restoration and Regeneration

    From cells to limbs – multi-scale approaches for
    clinical applications

    Wednesday 28th June – Friday 30th June 2006

    Abstract deadline 31st March 2006 !!!!

    Celebrating 10 years of Musculoskeletal research at the Center for
    Musculoskeletal Surgery, Charité - University Medicine Berlin.

    We are delighted to announce the forthcoming international Symposium,
    to be held in the Kaiserin-Friedrich buildings, Berlin.

    SUMMARY - In both knee joint replacement (endoprostheses) and
    regeneration (tissue engineering), mechanical conditions can either
    enhance or endanger the clinical outcome. Although this is generally
    accepted, the wider implications for clinical therapies have not yet
    been fully realised. The goal of this symposium is to formulate current
    concepts in knee regeneration and promote the translation of
    regenerative therapies into the clinic by bringing together
    outstanding researchers in the fields of cellular, tissue and
    musculoskeletal biomechanics.

    Chairmen E. Chao and T. Mittlmeier

    · Current knowledge of in vivo lower limb loading conditions
    D. D'Lima
    G. Bergmann
    · Knee kinematics and kinetics
    T. Andriacchi
    E. Valstar
    · Musculoskeletal interactions
    W. Herzog
    M. Heller
    · Round table discussion
    Which macro-mechanical aspects are most important for
    regeneration of the knee joint?

    Chairmen R. Huiskes and R. Hoffmann

    · Genetic basis for mechano-sensitivity
    A. Pitsillides
    S. Mundlos
    P. Fratzl
    · Cell level mechano-sensitivity
    D. Bader
    A. El Haj
    · Tissue level mechano-sensitivity
    S. Cowin
    J. Klein-Nulend
    L. Claes
    · Localised stimulation of healing using biomaterials
    P. Fratzl
    A. Lendlein
    A. Ignatius
    · Round table discussion
    What factors are essential to obtain tissue matrix of
    a clinically relevant quality?

    Chairmen H. Aro and T. Suedkamp

    · Bone
    D. Hutmacher
    F. Jakob
    G. Schmidmaier
    · Cartilage
    R. Sah
    M. Sittinger
    G. Duda
    · Soft Tissues
    J. Huard
    A. Weiler
    L. Duerselen
    · Round table discussion
    Global mechanics vs. local biological conditions – what is
    essential for clinical success?


    · “Innovations in Endoprostheses”
    U. Munzinger
    · “Current and Future Concepts in Stimulation”
    M. Raschke
    · “The Role of Cells in Surgery”
    C. Perka
    · “Remaining Limitations in Musculoskeletal Regeneration”
    A. Goodship

    ABSTRACTS - Abstracts for posters and presentations are now being
    accepted. The deadline for submission of abstracts is 31st March 2006.

    The best quality abstract submissions of no more than 300 words will
    be accepted on the topics and sub-topics presented above. Please find
    further details, including the submission form the on the web site at

    All oral presentations will be asked to provide a full manuscript for
    submission to a special edition of the Journal of Biomechanics.

    PRIZES - The best three student and best regular rated abstracts will
    receive free registration to the event.

    PRICE - Regular participants - Euro 250
    Student participants - Euro 150

    CELEBRATION - As a celebration of 10 years of musculoskeletal research
    at the Center for Musculoskeletal Surgery, Charité - Universtätsmedizin,
    Berlin, a full evening of entertainment will take place on the Thursday
    evening, included within the price of registration.

    In addition, the quarter finals of the world cup will be shown on the
    Friday evening on a big screen in the friendly atmosphere of the World
    Cup Capital!!!

    WEB - Further information can be found on the meeting at
    and on our research activities under

    BACKGROUND - Although destructive knee conditions can be successfully
    treated through surgical intervention or replacement, durable
    functionality of the lower limb is rarely completely regained due
    to the complex interaction of internal musculoskeletal loading and
    kinematics with the biology of the restored joint. Despite an
    incomplete understanding of these macro-mechanical interactions,
    which are known to be critical for the long-term outcome,
    considerable effort is being expended in translating tissue
    regeneration and tissue engineering techniques into therapies for
    musculoskeletal disorders. These approaches are in turn known to be
    critically affected by the micro-loading environment.

    Recent advances in both musculoskeletal biomechanics, as well as
    molecular and cell biological approaches to tissue engineering,
    lead to high expectations for scientists, clinicians and patients,
    especially in the knee joint. The parallel but independent
    advancement on both macro- and micro-scales is remarkable. Scientific
    interactions between these scales are essential for the development
    of new therapies since, in the patient, all scales are active from
    the operating theatre to postoperative physiotherapy. Mechano-biology
    plays a central role throughout in linking mechano-transduction and
    tissue engineering with macroscopic tissue behaviour and
    musculoskeletal loading. Successful translation into clinical practice
    additionally requires extensive interaction with physicians.

    The knee joint has been the target for many new treatments, as well as
    the focus of a number of basic scientific advances in recent years.
    Our initial meeting in 2000 concentrated on musculoskeletal loading
    conditions and a meeting in 2003 highlighted the contributions of soft
    tissues in musculoskeletal surgery. This upcoming event uses a focus
    on the knee joint to bring together outstanding biomechanical,
    mechano-biological and tissue regenerative research together with expert
    clinical knowledge to promote interaction and to outline an optimum
    strategy for bringing this research successfully into the clinic. The
    goal of this symposium is to identify strategic areas within, and
    interactions between, each discipline that are essential for bringing
    new therapies to the clinic, thereby formulating current concepts in
    knee restoration and regeneration.

    The Center for Musculoskeletal Surgery looks forward to welcoming you to
    Berlin, the football World Cup 2006 capital.

    Univ.-Prof. Dr.-Ing. Georg N. Duda
    Musculoskeletal Research Center Berlin
    Center for Musculoskeletal Surgery
    Charité, University Medicine Berlin
    Free and Humboldt-University of Berlin
    Augustenburger Platz 1
    D-13353 Berlin, Germany
    tel: +49 30 4505 59079
    fax: +49 30 4505 59969