-- Final Call for Abstracts --

Abstract deadline 31st March 2006




The Interaction of Mechanics and Biology in Knee Joint
Restoration and Regeneration

From cells to limbs – multi-scale approaches for
clinical applications

Wednesday 28th June – Friday 30th June 2006

We are delighted to invite you to submit abstracts to the forthcoming
international Symposium, to be held in the Kaiserin-Friedrich buildings,

Celebrating 10 years of Musculoskeletal research at the Center for
Musculoskeletal Surgery, Charité - Universitätsmedizin Berlin.

SUMMARY - In both knee joint replacement (endoprostheses) and
regeneration (tissue engineering), mechanical conditions can either
enhance or endanger the clinical outcome. Although this is generally
accepted, the wider implications for clinical therapies have not yet
been fully realised. The goal of this symposium is to formulate current
concepts in knee regeneration and promote the translation of
regenerative therapies into the clinic by bringing together
outstanding researchers in the fields of cellular, tissue and
musculoskeletal biomechanics.

Chairmen E. Chao and T. Mittlmeier

· Current knowledge of in vivo lower limb loading conditions
D. D'Lima
G. Bergmann
· Knee kinematics and kinetics
T. Andriacchi
E. Valstar
· Musculoskeletal interactions
W. Herzog
M. Heller
· Round table discussion
Which macro-mechanical aspects are most important for
regeneration of the knee joint?

Chairmen R. Huiskes and R. Hoffmann

· Genetic basis for mechano-sensitivity
A. Pitsillides
S. Mundlos
P. Fratzl
· Cell level mechano-sensitivity
D. Bader
A. El Haj
· Tissue level mechano-sensitivity
S. Cowin
J. Klein-Nulend
L. Claes
· Localised stimulation of healing using biomaterials
P. Fratzl
A. Lendlein
A. Ignatius
· Round table discussion
What factors are essential to obtain tissue matrix of
a clinically relevant quality?

Chairmen H. Aro and T. Suedkamp

· Bone
D. Hutmacher
F. Jakob
G. Schmidmaier
· Cartilage
R. Sah
M. Sittinger
G. Duda
· Soft Tissues
J. Huard
A. Weiler
L. Duerselen
· Round table discussion
Global mechanics vs. local biological conditions – what is
essential for clinical success?


· “Innovations in Endoprostheses”
U. Munzinger
· “Current and Future Concepts in Stimulation”
M. Raschke
· “The Role of Cells in Surgery”
C. Perka
· “Remaining Limitations in Musculoskeletal Regeneration”
A. Goodship

ABSTRACTS - Abstracts for posters and presentations are now being
accepted. The deadline for submission of abstracts is 31st March 2006.

The best quality abstract submissions of no more than 300 words will
be accepted on the topics and sub-topics presented above. Please find
further details, including the submission form the on the web site at

All oral presentations will be asked to provide a full manuscript for
submission to a special edition of the Journal of Biomechanics.

PRIZES - The best three student and best regular rated abstracts will
receive free registration to the event.

PRICE - Regular participants - Euro 250
Student participants - Euro 150

CELEBRATION - As a celebration of 10 years of musculoskeletal research
at the Center for Musculoskeletal Surgery, Charité - Universtätsmedizin,
Berlin, a full evening of entertainment will take place on the Thursday
evening, included within the price of registration.

In addition, the quarter finals of the world cup will be shown on the
Friday evening on a big screen in the friendly atmosphere of the World
Cup Capital!!!

WEB - Further information can be found on the meeting at www.knee2006.de
and on our research activities under www.charite.de/cmsc

BACKGROUND - Although destructive knee conditions can be successfully
treated through surgical intervention or replacement, durable
functionality of the lower limb is rarely completely regained due
to the complex interaction of internal musculoskeletal loading and
kinematics with the biology of the restored joint. Despite an
incomplete understanding of these macro-mechanical interactions,
which are known to be critical for the long-term outcome,
considerable effort is being expended in translating tissue
regeneration and tissue engineering techniques into therapies for
musculoskeletal disorders. These approaches are in turn known to be
critically affected by the micro-loading environment.

Recent advances in both musculoskeletal biomechanics, as well as
molecular and cell biological approaches to tissue engineering,
lead to high expectations for scientists, clinicians and patients,
especially in the knee joint. The parallel but independent
advancement on both macro- and micro-scales is remarkable. Scientific
interactions between these scales are essential for the development
of new therapies since, in the patient, all scales are active from
the operating theatre to postoperative physiotherapy. Mechano-biology
plays a central role throughout in linking mechano-transduction and
tissue engineering with macroscopic tissue behaviour and
musculoskeletal loading. Successful translation into clinical practice
additionally requires extensive interaction with physicians.

The knee joint has been the target for many new treatments, as well as
the focus of a number of basic scientific advances in recent years.
Our initial meeting in 2000 concentrated on musculoskeletal loading
conditions and a meeting in 2003 highlighted the contributions of soft
tissues in musculoskeletal surgery. This upcoming event uses a focus
on the knee joint to bring together outstanding biomechanical,
mechano-biological and tissue regenerative research together with expert
clinical knowledge to promote interaction and to outline an optimum
strategy for bringing this research successfully into the clinic. The
goal of this symposium is to identify strategic areas within, and
interactions between, each discipline that are essential for bringing
new therapies to the clinic, thereby formulating current concepts in
knee restoration and regeneration.

The Center for Musculoskeletal Surgery looks forward to welcoming you to
Berlin, the football World Cup 2006 capital.

Univ.-Prof. Dr.-Ing. Georg N. Duda
Musculoskeletal Research Center Berlin
Center for Musculoskeletal Surgery
Charité, University Medicine Berlin
Free and Humboldt-University of Berlin
Augustenburger Platz 1
D-13353 Berlin, Germany
tel: +49 30 4505 59079
fax: +49 30 4505 59969
email georg.duda@charite.de