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Dear Experts,
I do clinical research in the veterinary field using a ForcePlate set up to
acquire Ground Reaction Force particularly in dogs afflicted by
osteoarthritis. In my latest clinical trials, I encountered a problem. Let
me explain: A group of dogs was followed over time (baseline, Week-4 and
Week-12) to pinpoint the effect of a therapeutic modality. Dogs
significantly increased their body weight between Week-4 and Week-12, while
Week-4 and baseline’s body weight were similar. As recommended I analysed
the Peak Vertical Force (primary study outcome) expressed in percentage of
body weight. This gain in body weight could have biased the study and
consequently, mask a possible beneficial effect. Does a mathematical or
statistical approach exist to limit the effect of weight increase on PVF
values?
Your help and opinion are obviously welcome
Cordially
Maxim Moreau
Université de Montréal, Canada
I do clinical research in the veterinary field using a ForcePlate set up to
acquire Ground Reaction Force particularly in dogs afflicted by
osteoarthritis. In my latest clinical trials, I encountered a problem. Let
me explain: A group of dogs was followed over time (baseline, Week-4 and
Week-12) to pinpoint the effect of a therapeutic modality. Dogs
significantly increased their body weight between Week-4 and Week-12, while
Week-4 and baseline’s body weight were similar. As recommended I analysed
the Peak Vertical Force (primary study outcome) expressed in percentage of
body weight. This gain in body weight could have biased the study and
consequently, mask a possible beneficial effect. Does a mathematical or
statistical approach exist to limit the effect of weight increase on PVF
values?
Your help and opinion are obviously welcome
Cordially
Maxim Moreau
Université de Montréal, Canada