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  • NYC Bone Seminar - Fall 06 Series

    Hi Folks:

    The Fall 2006 Bone Seminar Series begins on Tuesday, September 12th
    with a presentation by Philipp Mayer-Kuckuk, Ph.D., Memorial
    Sloan-Kettering, UMDNJ and Hospital for Special Surgery. He will
    speak on " Strategies for imaging bone cell biology in mice and man"

    Please respond to the request for feedback on the continuation of
    seminar refreshments below.

    Details about all seminars appear below as well as on our website:
    http://bonenet.net

    The contents of the rest of this email are as follows:
    [1] Bone Seminar Series: General Information
    [2] September 12th, 2006 Phillipp Mayer-Kuckuk PhD Host: Chris Fritton
    [3] October 17th, 2006 Shelly Buffenstein PhD Host: Bob Majeska
    [4] November 14th, 2006 Elizabeth Shane MD Host: Ed Guo
    [5] December 5th, 2006 Gordana Vunjak-Novakovic Host: Ed Guo


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    THE BONE SEMINAR SERIES

    The Bone Seminar Series has as its focus the mechanosensory system in
    bone. Seminar program and workshop information are regularly posted
    on www.bonenet.net, a website dedicated to research on the
    mechanosensory system in bone. Please send comments on the website to
    the webmaster, Bill Green or to me
    . Please let us have your comments.

    XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX

    THE FALL 2006 BONE SEMINAR PROGRAM

    Seminars will be held on Tuesdays from 7:00 to about 8:30 PM in the
    rooms indicated in the CUNY Graduate Center at the corner of 34th
    Street and 5th Avenue, catty-corner from the Empire State Building.
    There will be some socializing before the seminar in the seminar room
    from 5:45 PM.
    There are several subway lines nearby, and it is less than a
    ten-minute walk to either Grand Central Station or Penn Station.
    There is money to support parking for graduate students; apply to
    Steve Cowin (contact information at the bottom).

    A REQUEST FOR FEEDBACK ON THE CONTINUATION OF SEMINAR REFRESHMENTS

    The refreshments that were available before the seminars in previous
    years will not be available to the first seminar of the fall 2006
    series and, possibly, in subsequent seminars. I would appreciate your
    opinion and/or suggestions on the possible reinstitution of seminar
    refreshments, given the cost. Any refreshments at the Graduate center
    must be purchased from an in-house organization (Restaurant
    Associates at The Graduate Center -CUNY, Catering Department). Until
    February of 2006 the cost of each seminar's refreshments was $215. In
    March of 2006 the cost of the same refreshments jumped to $375 due to
    a surcharge of $160 that was added for "late night service." Given
    that we have an average attendance of about 25, these refreshments
    cost about $15 per person. If a significant number of our attendees
    think that this is an important feature of the seminar (given this
    cost), I will find the money to do it. I would like to hear from
    attendees (pro and con) on this issue and learn of any alternative
    suggestions, .

    XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX

    SEPTEMBER 12th , 2006 in room C205 at the CUNY
    Graduate Center at 7:00 PM

    Speaker: PHILIPP MAYER-KUCKUK, Ph.D., In Vivo Cellular Molecular
    Imaging Center, Memorial Sloan-Kettering Cancer Center and Department
    of Pharmacology, UMDNJ Musculoskeletal Integrity Program, Hospital
    for Special Surgery

    Title: STRATEGIES FOR IMAGING BONE CELL BIOLOGY
    IN MICE AND MAN

    Host: Chris Fritton

    ABSTRACT: Bone is a highly complex tissue. It is composed of cells
    such as the complementing osteoblasts and osteoclasts as well as
    organic macromolecules and mineral. Physiologically relevant studies
    of cell-cell and cell-structure interactions within this composite
    tissue often demand in vivo observations. To this end we have
    proposed the application of a novel investigation strategy called
    Molecular Imaging. We suggest that this method may allow for the
    non-invasive detection and measurement of biological pathways in a
    living subject and we are among the institutions pioneering this
    approach for orthopedic research. This presentation will provide an
    overview of several of our upcoming studies that will utilize
    advanced molecular imaging for the study of bone cell biology. Over
    the course of the talk, I will introduce molecular imaging, discuss
    the reporter gene imaging concept, outline GAIM: Genetically Altered
    and Imaging Competent Mice, and describe SIM: Small Imaging Molecules
    which may allow future clinical application of orthopedic molecular
    imaging

    RESEARCH INTERESTS OF PHILIPP MAYER-KUCKUK: Osteoblast and osteoclast
    biology, including precursor cells and mechanotransduction;
    pre-clinical and clinical molecular imaging; osteogenesis imperfecta

    XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX

    OCTOBER 17th, 2006 in room C205 at the CUNY Graduate Center at 7:00 PM

    Speaker: ROCHELLE BUFFENSTEIN, Ph.D. and YAEL GRUN-KRAMER, Department
    of Biology, City College of New York

    Host: Bob Majeska

    Title: AGE-RELATED CHANGES IN BONE METABOLISM IN THE
    LONGEST-LIVING RODENT, THE NAKED MOLE-RAT

    ABSTRACT: Naked mole-rats are the longest-living rodent known, living
    eight times longer than similar-sized mice and exhibiting a similar
    longevity quotient (the ratio of actual lifespan to that predicted by
    body mass) to humans. These highly social rodents, unlike most
    mammals appear to retain the ability to reproduce throughout their
    long lives. Age-related changes in body composition, metabolism and
    physiological function are markedly attenuated suggesting that rates
    of aging are retarded; however the mechanisms protecting naked
    mole-rats from the ubiquitous aging process and concomitant
    age-related diseases are unknown. As aging occurs, the efficiency of
    bones to respond to endogenous and environmental stresses declines
    such that bone remodeling is attenuated. This may result in a net
    loss of bone mineral content and increased risk of fracture that
    contributes to the increase in frailty as all mammals age and
    ultimately leads to their demise. Mechanisms employed in bone aging
    are not well understood and there is a constant search for a more
    appropriate mammalian laboratory model for assessing bone aging.
    Given their long lifespan, we would expect that these rodents, unlike
    mice, would require protection of bone integrity and would employ
    highly efficient bone remodeling processes. Specifically, we
    hypothesize that as aging occurs bone quality and structure in the
    naked mole-rat will be retained, and that bone remodeling efficacy
    would be superior to that of mice. Cross sectional femur geometry
    data reveal that NMRs maintain thicker cortical bone than do mice and
    that age-related declines in cortical bone was very small. This
    appears to be most pronounced in breeding females. Furthermore,
    considerable evidence reveals that these rodents continuously remodel
    their trabecular bone and maintain structural integrity throughout
    their long lives. Clearly, given these features, NMRs may prove to be
    a useful model with which to study changes in bone with aging as well
    as the mechanisms that facilitate bone protection in long-lived
    mammals.

    RESEARCH INTERESTS OF SHELLEY BUFFENSTEIN: I am a comparative
    physiologist primarily interested in understanding the tremendous
    variability in maximum lifespan among species and the proximate
    mechanisms employed in aging. I currently am studying both
    age-related changes in physiological function in the longest-living
    rodent, the naked mole-rat as well as oxidative stress and other
    mechanisms of aging in rodents that show disparate longevity.

    XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX

    NOVEMBER 14th, 2006 in room C205 at the CUNY Graduate Center at 7:00 PM

    Speaker: ELIZABETH SHANE MD, Professor of Clinical Medicine,
    Columbia University

    Title: BONE QUALITY IN PREMENOPAUSAL WOMEN WITH
    UNEXPLAINED FRAGILITY FRACTURES

    Host: Ed Guo

    ABSTRACT: In this presentation, I will consider the causes of
    osteoporosis in premenopausal women and will review the results of
    recently published and ongoing studies focused on the pathogenesis of
    bone fragility in young, otherwise healthy women with unexplained
    fragility fractures, including static and dynamic quantitative
    histomorphometry, micro-CT, and mineralization density.

    RESEARCH INTERESTS OF ELIZABETH SHANE: Osteoporosis, Secondary
    Osteoporosis (Organ Transplantation, GI Tract Disease, Medications),
    Renal Bone Disease, Hyperparathyroidism

    XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX

    December 5th, 2006 in room 9204 at the CUNY Graduate Center at 7:00 PM

    Speaker: GORDANA VUNJAK-NOVAKOVIC PhD, Department of Biomedical
    Engineering, Columbia University

    Host: Ed Guo

    ABSTRACT: Human bone marrow contains a population of mesenchymal stem
    cells (hMSC) capable of forming several types of mesenchymal tissues,
    including bone and cartilage. In vitro expansion and cultivation of
    hMSC on biomaterial scaffolds could facilitate osteochondral repair,
    where functional autologous cartilage/bone constructs would be grown
    and subsequently implanted into the defect site to promote healing.
    In this talk, I'll discuss tissue engineering and animal studies of
    large, mineralized bone constructs and osteochondral grafts by
    bioreactor cultivation of hMSC on three-dimensional scaffolds. Under
    best culture conditions, the volume fractions of mineralized tissue
    came into the range of values measured for human lumbar verterbral
    bone.

    RESEARCH INTERESTS OF GORDANA VUNJAK-NOVAKOVIC: Tissue engineering of
    functional human grafts for clinical application and controlled
    studies of normal and pathological cell and tissue function. Our
    general approach is to use human stem cells (adult or embryonic) and
    culture them on three-dimensional scaffolds (designed to mimic the
    native tissue matrix) in bioreactors (designed to provide
    developmentally relevant molecular and physical regulatory factors).
    Two groups of tissues are of great interest to our lab: osteochondral
    (cartilage, bone, anatomically shaped stratified grafts) and cardiac
    (synchronously contractile cardiac muscle).

    XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX

    ORGANIZATION OF THE SEMINAR SERIES

    The Interinstitutional Steering Committee (ISC) will make
    decisions concerning the seminar series, including the selection of
    speakers. Interesting, high quality seminar speakers are sought.
    Seminar attendees are asked to help in the identification of
    investigators with new results relative to bone research, questions
    of current interest and distinguished bone researchers visiting New
    York City who might be persuaded to present a seminar. Presentations
    by advanced graduate students and post-docs are encouraged.
    The members of the Interinstitutional Steering Committee
    (ISC) are Adele Boskey (Head of the Mineralized Tissue Section at the
    Hospital for Special Surgery and Professor of Biochemistry at the
    Weill Medical College of Cornell University), Timothy Bromage
    (Director, Hard Tissue Research Unit, New York University College of
    Dentistry), Stephen C. Cowin (Professor of Biomedical and Mechanical
    Engineering at the City College of the City University of New York
    (CUNY)), Susannah P. Fritton (Director of the Tissue Mechanics
    Laboratory, New York Center for Biomedical Engineering and Associate
    Professor of Biomedical Engineering at the City College of CUNY), X.
    Edward Guo (Director of the Bone Bioengineering Laboratory and
    Associate Professor of Bioengineering at Columbia University),
    Clinton T. Rubin (Professor and Chair of the Department of Biomedical
    Engineering, and Director of the Center for Advanced Technology in
    Medical Biotechnology at SUNY Stony Brook) and Mitchell B. Schaffler
    (Director of Orthopaedic Research and Professor of Orthopedics, Cell
    Biology and Anatomy at the Mount Sinai School of Medicine). Each of
    these people represents a community consisting of senior bone
    research people, graduate students and, in most cases, undergraduate
    students.

    PLEASE DIRECT YOUR QUESTIONS AND FEEDBACK TO

    Stephen C. Cowin
    New York Center for Biomedical Engineering
    Departments of Biomedical and Mechanical Engineering
    School of Engineering
    The City College
    138th Street and Convent Avenue
    New York, NY 10031-9198, U. S. A.

    Phone (212) 799-7970 (Office at Home)
    Fax (212) 799-7970 (Office at Home)
    Phone (212) 650-5208 (Work)
    Email
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