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Summary: Minimizing group differences at baseline in controlledtrials

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  • Summary: Minimizing group differences at baseline in controlledtrials

    Two months ago I sent a message to the BIOMCH-L and Sportscience lists
    asking for volunteers to try out the spreadsheets I devised to allocate
    subjects to groups in a manner that minimizes differences in group means of
    subject characteristics. I ended up with feedback from several people,
    thank you. The article is now written and peer-reviewed. Go to to view the article explaining the gains in
    precision with minimization and to download the spreadsheets.

    There are bound to be a few bugs in the spreadsheets and errors in the
    article. Please get back to me if you find anything worth fixing.

    By the way, in the process of checking this article on the Web I discovered
    that Firefox produces pixelly images from the html conversions I do from the
    original Word doc. There is also a problem with some symbols of the symbol
    font with Firefox 3. I have also been playing with the screen resolution
    since I got a new laptop this week, and I found that Firefox does not render
    pages within frames correctly when I change the DPI setting from normal (96
    DPI) to the large (120 DPI) or a custom setting. None of these problems
    occur with Internet Explorer. I don't know about other browsers. I found
    also that Dreamweaver does not display its windows correctly with anything
    other than the normal DPI setting. In fact it's practically unusable. Bottom
    line for me is that I HAVE to use a screen resolution (1440 x 900) that is
    less the optimum (1680 x 1050) in order to be able to read the screen, but
    the result is a degraded fuzzy display. Does anyone have a solution? I have
    played with larger font sizes with 1680 x 1050 resolution, but there are
    many windows that don't respond to the new fonts and I end up with a
    disgusting mess. My IT people aren't any help.

    Will G Hopkins, PhD FACSM
    Contact info:
    Be creative: break rules.