No announcement yet.

collagen fiber deformations

This topic is closed.
  • Filter
  • Time
  • Show
Clear All
new posts

  • collagen fiber deformations

    A few months ago I posted the following message:

    J. Michael Lee recently mailed to me the following interesting
    A couple of years ago we were very interested in whether displacement of
    markers attached to the surface of tissue samples gave accurate reflections of
    internal deformations. We made a micro-tensile tester similar to that
    described in the 70's by Neil Broom and used it to deform uniaxial samples of
    canine pericardium---a tissue which is nearly transparent. This device was
    mounted on a microscope so we could follow internal structure using
    birefringence microscopy. We placed small graphite particles on the tissue
    surface, or glued on small metal flakes. What we discovered was that the
    tissue surface (at least in simple tensile tests) often deforms by quite
    different amounts than does the internal structure. We were very concerned
    about this as you can imagine. I would urge anyone relying on this type of
    system to develop appropriate control experiments to confirm the relationship
    between internal/surface deformation.

    I would like to start a discussion on this topic of inter-laminar
    collagen fiber mobility when the tissue is stretched. This result
    could potentially affect much of the biomechanical data collection
    techniques that have been used for decades for soft tissues. Please
    feel free to respond freely with your ideas. As usual, I will attempt
    to put together all the responses into a single file when I feel we
    have exhausted the subject.

    As luck would have it, I ran out of time to really moderate this
    discussion. I would like to have another go at it. Please post
    your thoughts on this topic or any other related to the micro-
    mechanical basis of soft tissue mechanical behavior.

    Best regards,

    Michael Sacks, Ph.D.
    Dept. of Biomedical Eng.
    U. Miami