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muscle cell mechanics

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  • muscle cell mechanics

    Dear Biomch-l readers,

    In order to study the aetiology of pressure sores we (dept. of Computational
    and Experimental Mechanics, Eindhoven University of Technology & dept. of
    Human Movement Sciences, Maastricht University) are developing a numerical
    model and an animal model to obtain knowledge about the basic mechanisms
    whereby 'external' mechanical loads (i.e. applied to the skin) result in soft
    tissue degeneration, especially muscle tissue degeneration.

    In addition, I am involved in the development and characterization of an
    'in-vitro' model to study muscle cell deformation and damage as a consequence
    of compressive loading. For this purpose I would like to compress cultured
    myotubes in agarose gel and visualize them by (confocal) microscopy.
    This technique is used before in other cells, but little information is
    available about muscle cells in agarose and/or under compression.
    I would like to knnow if someone has experience with this kind of research
    or has information about muscle cells or muscle tissue under compression.

    Thanking you in advance,

    Carlijn Bouten
    Eindhoven University of Technology
    The Netherlands