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Dear Biomch-L readers,
Since Dan Sheffer who usually monitors the NIH Guide
for Biomch-L is currently on holiday (his Biomch-L subscription is on NOMAIL),
I am posting the below notice as received this morning on his behalf. While
hormonal matters may seem outside the scope of Biomechanics & Movement Science,
I should think that (in vitro) testing of bone samples might quite well fall
within our target domain.
Sincerely -- hjw.
$$R2 BEGIN DK-92-20 FULL-TEXT ***************************************
HORMONAL REGULATION OF BONE IN HEALTH AND DISEASE
NIH GUIDE, Volume 21, Number 21, June 5, 1992
RFA AVAILABLE: DK-92-20
P.T. 34; K.W. 0705050, 0760025, 0775000
National Institute of Diabetes and Digestive and Kidney Diseases
National Institute of Arthritis and Musculoskeletal and Skin Diseases
Letter of Intent Receipt Date: July 10, 1992
Application Receipt Date: August 25, 1992
NOTE: THE FULL TEXT OF THE REQUEST FOR APPLICATIONS (RFA) SHOULD BE
REQUESTED - SEE INQUIRIES SECTION.
PURPOSE
The National Institute of Diabetes and Digestive and Kidney Diseases
(NIDDK) and the NIAMS invite investigator-initiated research grant
applications to elucidate the role(s) of systemic and local hormones,
growth factors, and cytokines on bone in health and disease.
HEALTHY PEOPLE 2000
The Public Health Service (PHS) is committed to achieving the health
promotion and disease prevention objectives of "Healthy People 2000,"
a PHS-led national activity for setting priority areas. Potential
applicants may obtain a copy of "Healthy People 2000" (Full Report:
Stock No. 017-001-00474-0) or "Healthy People 2000" (Summary Report:
Stock No. 017-001-00473-1) through the Superintendent of Documents,
Government Printing Office, Washington, D.C. 20402-9325 (telephone
202-783-3238).
ELIGIBILITY REQUIREMENTS
Applications may be submitted by domestic and foreign, for-profit and
nonprofit organizations, public and private, such as universities,
colleges, hospitals, laboratories, units of State and local
governments, and eligible agencies of the Federal Government. Minority
individuals and women are encouraged to submit as Principal
Investigators.
MECHANISM OF SUPPORT
Support of this program will be through the NIH research project (R01)
award. Responsibility for the planning, direction, and execution of
the proposed project will be solely that of the applicant. Except as
otherwise stated in this announcement, awards will be administered
under PHS grants policy as stated in the Public Health Service Grants
Policy Statement.
This RFA is a one-time solicitation. Future unsolicited competing
continuation applications will compete with all investigator-initiated
applications and reviewed according to the customary peer review
procedures. The total project period for applications submitted in
response to the present RFA may not exceed five years. A maximum of
three years may be requested for foreign awards. The earliest possible
award date will be April 1, 1993.
FUNDS AVAILABLE
For FY 93, the NIDDK intends to commit $2,000,000 to fund applications
submitted in response to this RFA and the NIAMS intends to commit a
further $2,000,000 to this RFA. However, this funding level is
dependent upon the receipt of a sufficient number of applications of
high scientific merit. In order to help meet NIH goals for managing
the costs of biomedical research, applicants must limit requests to not
more than $160,000 direct costs for the initial budget period.
Although this program is provided for in the financial plans of the
NIDDK and the NIAMS, the award of grants pursuant to this RFA is also
contingent upon the availability of funds for this purpose.
RESEARCH OBJECTIVES
This initiative is intended to foster research on the molecular
mechanisms of action of hormones and related factors on a major
endocrine target organ: bone. This research will advance the
understanding of the molecular mechanisms by which hormones regulate
normal growth and homeostasis of bone and how alterations in hormonal
status cause disease. Ultimately, such research may lead to design of
hormone analogs with specific desirable properties for therapy of bone
disorders based on new understandings of molecular endocrinology.
SPECIAL REQUIREMENTS
Interdisciplinary approaches may be needed for these studies with
expertise required in one or more of the following areas: molecular
and cellular biology, endocrinology, physiology, pathology, and
pharmacology.
STUDY POPULATIONS
It is NIH policy that women and minorities must be included in clinical
study populations unless there is a good reason to exclude them, and
the study design must seek to identify any pertinent gender or minority
population differences.
SPECIAL INSTRUCTIONS FOR INCLUSION OF WOMEN AND MINORITIES IN CLINICAL
RESEARCH STUDIES
For projects involving clinical research, NIH requires applicants to
give special attention to the inclusion of women and minorities in
study populations. If women or minorities are not included in the
study populations for clinical studies, a specific justification for
this exclusion must be provided. Applications without such
documentation will not be accepted for review.
LETTER OF INTENT
Prospective applicants are asked to submit, by July 10, 1992, a letter
of intent that includes a descriptive title of the proposed research,
the name, address, and telephone number of the Principal Investigator,
the identities of other key personnel and participating institutions,
and the number and title of the RFA in response to which the
application is being submitted.
Although a letter of intent is not required, is not binding, and does
not enter into the review of subsequent applications, the information
that it contains is helpful in planning for the review of applications.
It allows NIDDK staff to estimate the potential review workload and to
avoid possible conflict of interest in the review.
A letter of intent is to be sent to:
Chief, Review Branch
Division of Extramural Activities
National Institute of Diabetes and Digestive and Kidney Diseases
Westwood Building, Room 605
Bethesda, MD 20892
Telephone: (301) 496-7083
APPLICATION PROCEDURES
Applications are to be submitted using form PHS 398 (rev. 9/91)
available in the business or grants offices of most academic or
research institutions and from the Office of Grants Inquiries, Division
of Research Grants, National Institutes of Health, 5333 Westbard
Avenue, Room 449, Bethesda, MD 20892, telephone 301-496- 7441.
REVIEW CONSIDERATIONS
Applications that are complete and responsive to the RFA will be
evaluated by an appropriate peer review group convened by the NIDDK in
accordance with the usual NIH peer review procedures. Following
review, the applications will be given a secondary review by the NIDDK
and NIAMS Advisory Councils unless not recommended for further
consideration by the initial review group. Applications that are
incomplete or unresponsive to the RFA will be returned to the applicant
or held until the next receipt date, if requested by the applicant, and
reviewed by the Division of Research Grants.
The National Institute on Aging (NIA), and the National Institute of
Dental Research (NIDR) also have an interest in supporting areas of
research covered by this RFA. The PHS Referral Guidelines will prevail
in the institute assignment of applications.
INQUIRIES
Written and telephone inquiries concerning this RFA are encouraged.
Direct inquiries regarding programmatic issues and requests for copies
of the RFA should be directed to:
Ronald N. Margolis, Ph.D.
Endocrinology Research Program
Division of Diabetes, Endocrinology and Metabolic Diseases
National Institute of Diabetes and Digestive and Kidney Diseases
Westwood Building, Room 621
Bethesda, MD 20892
Telephone: (301) 496-7504
Joan A. McGowan, Ph.D.
Chief, Bone Biology and Bone Diseases Branch
National Institute of Arthritis and Musculoskeletal and Skin Diseases
Westwood Building, Room 403
Bethesda, MD 20892
Telephone: (301) 480-7881
Direct inquiries regarding fiscal matters to:
Sharon Tempchin
Grants Management Specialist
Division of Extramural Activities
National Institute of Diabetes and Digestive and Kidney Diseases
5333 Westbard Avenue, Room 649D
Bethesda, MD 20892
Telephone: (301) 496-7467
AUTHORITY AND REGULATIONS
This program is described in the Catalog of Federal Domestic Assistance
No. 93.847 and 93.846. Awards are made under authorization of the
Public Health Service Act, Title IV, Part A (Public Law 78-410, as
amended by Public Law 99-158, 42 USC 241 and 285) and administered
under PHS grants policies and Federal Regulations 42 CFR 52 and 45 CFR
Part 74. This program is not subject to the intergovernmental review
requirements of Executive Order 12372 or Health Systems Agency review.
$$R2 END ************************************************** **********
Since Dan Sheffer who usually monitors the NIH Guide
for Biomch-L is currently on holiday (his Biomch-L subscription is on NOMAIL),
I am posting the below notice as received this morning on his behalf. While
hormonal matters may seem outside the scope of Biomechanics & Movement Science,
I should think that (in vitro) testing of bone samples might quite well fall
within our target domain.
Sincerely -- hjw.
$$R2 BEGIN DK-92-20 FULL-TEXT ***************************************
HORMONAL REGULATION OF BONE IN HEALTH AND DISEASE
NIH GUIDE, Volume 21, Number 21, June 5, 1992
RFA AVAILABLE: DK-92-20
P.T. 34; K.W. 0705050, 0760025, 0775000
National Institute of Diabetes and Digestive and Kidney Diseases
National Institute of Arthritis and Musculoskeletal and Skin Diseases
Letter of Intent Receipt Date: July 10, 1992
Application Receipt Date: August 25, 1992
NOTE: THE FULL TEXT OF THE REQUEST FOR APPLICATIONS (RFA) SHOULD BE
REQUESTED - SEE INQUIRIES SECTION.
PURPOSE
The National Institute of Diabetes and Digestive and Kidney Diseases
(NIDDK) and the NIAMS invite investigator-initiated research grant
applications to elucidate the role(s) of systemic and local hormones,
growth factors, and cytokines on bone in health and disease.
HEALTHY PEOPLE 2000
The Public Health Service (PHS) is committed to achieving the health
promotion and disease prevention objectives of "Healthy People 2000,"
a PHS-led national activity for setting priority areas. Potential
applicants may obtain a copy of "Healthy People 2000" (Full Report:
Stock No. 017-001-00474-0) or "Healthy People 2000" (Summary Report:
Stock No. 017-001-00473-1) through the Superintendent of Documents,
Government Printing Office, Washington, D.C. 20402-9325 (telephone
202-783-3238).
ELIGIBILITY REQUIREMENTS
Applications may be submitted by domestic and foreign, for-profit and
nonprofit organizations, public and private, such as universities,
colleges, hospitals, laboratories, units of State and local
governments, and eligible agencies of the Federal Government. Minority
individuals and women are encouraged to submit as Principal
Investigators.
MECHANISM OF SUPPORT
Support of this program will be through the NIH research project (R01)
award. Responsibility for the planning, direction, and execution of
the proposed project will be solely that of the applicant. Except as
otherwise stated in this announcement, awards will be administered
under PHS grants policy as stated in the Public Health Service Grants
Policy Statement.
This RFA is a one-time solicitation. Future unsolicited competing
continuation applications will compete with all investigator-initiated
applications and reviewed according to the customary peer review
procedures. The total project period for applications submitted in
response to the present RFA may not exceed five years. A maximum of
three years may be requested for foreign awards. The earliest possible
award date will be April 1, 1993.
FUNDS AVAILABLE
For FY 93, the NIDDK intends to commit $2,000,000 to fund applications
submitted in response to this RFA and the NIAMS intends to commit a
further $2,000,000 to this RFA. However, this funding level is
dependent upon the receipt of a sufficient number of applications of
high scientific merit. In order to help meet NIH goals for managing
the costs of biomedical research, applicants must limit requests to not
more than $160,000 direct costs for the initial budget period.
Although this program is provided for in the financial plans of the
NIDDK and the NIAMS, the award of grants pursuant to this RFA is also
contingent upon the availability of funds for this purpose.
RESEARCH OBJECTIVES
This initiative is intended to foster research on the molecular
mechanisms of action of hormones and related factors on a major
endocrine target organ: bone. This research will advance the
understanding of the molecular mechanisms by which hormones regulate
normal growth and homeostasis of bone and how alterations in hormonal
status cause disease. Ultimately, such research may lead to design of
hormone analogs with specific desirable properties for therapy of bone
disorders based on new understandings of molecular endocrinology.
SPECIAL REQUIREMENTS
Interdisciplinary approaches may be needed for these studies with
expertise required in one or more of the following areas: molecular
and cellular biology, endocrinology, physiology, pathology, and
pharmacology.
STUDY POPULATIONS
It is NIH policy that women and minorities must be included in clinical
study populations unless there is a good reason to exclude them, and
the study design must seek to identify any pertinent gender or minority
population differences.
SPECIAL INSTRUCTIONS FOR INCLUSION OF WOMEN AND MINORITIES IN CLINICAL
RESEARCH STUDIES
For projects involving clinical research, NIH requires applicants to
give special attention to the inclusion of women and minorities in
study populations. If women or minorities are not included in the
study populations for clinical studies, a specific justification for
this exclusion must be provided. Applications without such
documentation will not be accepted for review.
LETTER OF INTENT
Prospective applicants are asked to submit, by July 10, 1992, a letter
of intent that includes a descriptive title of the proposed research,
the name, address, and telephone number of the Principal Investigator,
the identities of other key personnel and participating institutions,
and the number and title of the RFA in response to which the
application is being submitted.
Although a letter of intent is not required, is not binding, and does
not enter into the review of subsequent applications, the information
that it contains is helpful in planning for the review of applications.
It allows NIDDK staff to estimate the potential review workload and to
avoid possible conflict of interest in the review.
A letter of intent is to be sent to:
Chief, Review Branch
Division of Extramural Activities
National Institute of Diabetes and Digestive and Kidney Diseases
Westwood Building, Room 605
Bethesda, MD 20892
Telephone: (301) 496-7083
APPLICATION PROCEDURES
Applications are to be submitted using form PHS 398 (rev. 9/91)
available in the business or grants offices of most academic or
research institutions and from the Office of Grants Inquiries, Division
of Research Grants, National Institutes of Health, 5333 Westbard
Avenue, Room 449, Bethesda, MD 20892, telephone 301-496- 7441.
REVIEW CONSIDERATIONS
Applications that are complete and responsive to the RFA will be
evaluated by an appropriate peer review group convened by the NIDDK in
accordance with the usual NIH peer review procedures. Following
review, the applications will be given a secondary review by the NIDDK
and NIAMS Advisory Councils unless not recommended for further
consideration by the initial review group. Applications that are
incomplete or unresponsive to the RFA will be returned to the applicant
or held until the next receipt date, if requested by the applicant, and
reviewed by the Division of Research Grants.
The National Institute on Aging (NIA), and the National Institute of
Dental Research (NIDR) also have an interest in supporting areas of
research covered by this RFA. The PHS Referral Guidelines will prevail
in the institute assignment of applications.
INQUIRIES
Written and telephone inquiries concerning this RFA are encouraged.
Direct inquiries regarding programmatic issues and requests for copies
of the RFA should be directed to:
Ronald N. Margolis, Ph.D.
Endocrinology Research Program
Division of Diabetes, Endocrinology and Metabolic Diseases
National Institute of Diabetes and Digestive and Kidney Diseases
Westwood Building, Room 621
Bethesda, MD 20892
Telephone: (301) 496-7504
Joan A. McGowan, Ph.D.
Chief, Bone Biology and Bone Diseases Branch
National Institute of Arthritis and Musculoskeletal and Skin Diseases
Westwood Building, Room 403
Bethesda, MD 20892
Telephone: (301) 480-7881
Direct inquiries regarding fiscal matters to:
Sharon Tempchin
Grants Management Specialist
Division of Extramural Activities
National Institute of Diabetes and Digestive and Kidney Diseases
5333 Westbard Avenue, Room 649D
Bethesda, MD 20892
Telephone: (301) 496-7467
AUTHORITY AND REGULATIONS
This program is described in the Catalog of Federal Domestic Assistance
No. 93.847 and 93.846. Awards are made under authorization of the
Public Health Service Act, Title IV, Part A (Public Law 78-410, as
amended by Public Law 99-158, 42 USC 241 and 285) and administered
under PHS grants policies and Federal Regulations 42 CFR 52 and 45 CFR
Part 74. This program is not subject to the intergovernmental review
requirements of Executive Order 12372 or Health Systems Agency review.
$$R2 END ************************************************** **********