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OpenSim Webinar: Interpreting Simulations in the Context of Clinical Variability

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  • OpenSim Webinar: Interpreting Simulations in the Context of Clinical Variability

    The OpenSim Project and the National Center for Simulation in Rehabilitation Research (NCSRR) at Stanford invite you to join our next webinar, featuring Kate Saul from North Carolina State University.

    Title: Interpreting Upper-limb Dynamic Simulations in the Context of Clinical Variability
    Speaker: Kate Saul, North Carolina State University
    Time: Tuesday, August 19, 2014 at 10:00 a.m. Pacific Daylight Time

    Clinical movement dysfunction and rehabilitation of the upper limb can pose a challenge to clinicians and researchers due to concomitant injuries or disabilities and multiple concurrent treatments. For example, injury to the brachial plexus may be accompanied by penetrating wounds or bone fracture, and multiple concurrent surgical approaches may be used for repair and to restore function. Musculoskeletal simulations can elucidate isolated effects of an injury or treatment and provide treatment guidelines for clinicians. However, computational results must be interpreted in the context of variability of human anatomy and clinical condition.

    In this webinar, I will describe how we have incorporated clinical knowledge to interpret our upper limb musculoskeletal simulations for two case studies. Our first study evaluated the biomechanical consequences of nerve transfer strategies to restore function following adult brachial plexus injuries. This involved running a series of simulations with different post-surgical muscle activation capacities to capture the variability in post-surgical patient response. Our second study explored shoulder deformity following the special case of brachial plexus birth palsy, by representing two potential deformity mechanisms: muscle force imbalance at the shoulder and abnormal muscle growth. Simulation results were used to evaluate the sensitivity of joint forces and range of motion to these mechanisms, enabling us to identify appropriate muscle targets for treatment.

    During this presentation, I will discuss the results of these two studies and highlight some of the key steps we took to achieve them, including:
    • Developing a new dynamic upper limb model in OpenSim
    • Incorporating clinical features and variability into models and simulation
    • Using CMC and joint force analysis to obtain clinically relevant outcome measures

    Participation is free, but you must register in advance. We also ask that you join the webinar 5 minutes early to orient yourself to the webinar interface.

    Visit our website for more information and registration. The website also includes links to recordings of past webinars:

    The OpenSim Webinar Series is funded by the NIH National Center for Simulation in Rehabilitation Research (NCSRR). Find out more about the NCSRR and the webinar series by visiting our website,