PhD Position in Bioimaging/Biomechanics at ETH Zurich and The University
of Sydney

Fracture repair is a hot topic for advancement due to clinical need.
With recent advances in genetics and new pharmacological treatments
there is a strong need for new techniques and methods to facilitate
biological quantification for structure-function assessment in skeletal
repair research. There, a number of new microstructural imaging
modalities have been put forward allowing phenotypic quantification with
high precision and accuracy in humans and animals, especially in the
mouse. In the Institute for Biomechanics at ETH Zurich, new strategies
for quantitative 3D bioimaging are investigated. Micro-computed
tomography (µCT) is such an approach used to image and quantify bone in
three dimensions (3D) providing resolutions ranging from a few
millimeters down to one hundred nanometers. Recently, a synchrotron
radiation-based computed tomography (SR CT) station has been designed
and implemented at the Swiss Light Source (SLS) of the Paul Scherrer
Institut (PSI) allowing 3D and fully nondestructive access to the
ultrastructure of biological materials. Moreover, composition and
material properties of bone tissue are investigated via internal ETH
collaboration using other techniques such as Raman spectroscopy and
nanoindentation. These technologies will be further developed to
quantify bone healing in normal, pathological and pharmacologically
treated models of bone repair.

This project has the following aims:

1) Develop new methods for quantitative phenotyping of fracture repair
in bone tissue, using µCT, SR CT, Raman spectroscopy, and
nanoindentation. Apply these newly developed methods for examining
fracture repair in normal, pathological, and treated bone.

2) Develop andestablish image-guided failure assessment (IGFA) for the
investigation of microscopic failure behavior of normal, pathological,
and treated bone, using SR CT.

The Institute for Biomechanics at ETH Zurich, in collaboration with
Orthopaedic Research at the University of Sydney, Australia, is seeking
to appoint a highly motivated PhD candidate pursuing research in these
areas. The successful candidate will work within an international and
interdisciplinary team of biologists, engineers and physicists at ETH
Zurich and will have the opportunity to collaborate closely with the SLS
at PSI. The motivated candidate will also pursue opportunities to spend
at least one year of the PhD in Australia. The applicant should have a
recent master degree in Engineering or a related field. Good skills in
both spoken and written English are mandatory to work in an
international, young and dynamic team. Knowledge in Bioimaging, Signal
Processing, Biomechanics and/or Bioengineering is an advantage. The
position is available upon January 2011 or upon mutual agreement.
Salaries are highly competitive and are in line with the guidelines of
ETH Zurich.

A curriculum vitae, a list of two references and all university classes
attended (including grades) as well as a one-page statement of your
background and research interest should be sent to (preferably by email):

Dr. Philipp Schneider
Institute for Biomechanics
ETH Zurich, Wolfgang-Pauli-Strasse 10, 8093 Zurich, Switzerland
Email:, Web: