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PhD Position in Bioimaging/Biomechanics at ETH Zurich and TheUniversity of Sydney

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  • PhD Position in Bioimaging/Biomechanics at ETH Zurich and TheUniversity of Sydney

    PhD Position in Bioimaging/Biomechanics at ETH Zurich and The University
    of Sydney

    Fracture repair is a hot topic for advancement due to clinical need.
    With recent advances in genetics and new pharmacological treatments
    there is a strong need for new techniques and methods to facilitate
    biological quantification for structure-function assessment in skeletal
    repair research. There, a number of new microstructural imaging
    modalities have been put forward allowing phenotypic quantification with
    high precision and accuracy in humans and animals, especially in the
    mouse. In the Institute for Biomechanics at ETH Zurich, new strategies
    for quantitative 3D bioimaging are investigated. Micro-computed
    tomography (µCT) is such an approach used to image and quantify bone in
    three dimensions (3D) providing resolutions ranging from a few
    millimeters down to one hundred nanometers. Recently, a synchrotron
    radiation-based computed tomography (SR CT) station has been designed
    and implemented at the Swiss Light Source (SLS) of the Paul Scherrer
    Institut (PSI) allowing 3D and fully nondestructive access to the
    ultrastructure of biological materials. Moreover, composition and
    material properties of bone tissue are investigated via internal ETH
    collaboration using other techniques such as Raman spectroscopy and
    nanoindentation. These technologies will be further developed to
    quantify bone healing in normal, pathological and pharmacologically
    treated models of bone repair.

    This project has the following aims:

    1) Develop new methods for quantitative phenotyping of fracture repair
    in bone tissue, using µCT, SR CT, Raman spectroscopy, and
    nanoindentation. Apply these newly developed methods for examining
    fracture repair in normal, pathological, and treated bone.

    2) Develop andestablish image-guided failure assessment (IGFA) for the
    investigation of microscopic failure behavior of normal, pathological,
    and treated bone, using SR CT.

    The Institute for Biomechanics at ETH Zurich, in collaboration with
    Orthopaedic Research at the University of Sydney, Australia, is seeking
    to appoint a highly motivated PhD candidate pursuing research in these
    areas. The successful candidate will work within an international and
    interdisciplinary team of biologists, engineers and physicists at ETH
    Zurich and will have the opportunity to collaborate closely with the SLS
    at PSI. The motivated candidate will also pursue opportunities to spend
    at least one year of the PhD in Australia. The applicant should have a
    recent master degree in Engineering or a related field. Good skills in
    both spoken and written English are mandatory to work in an
    international, young and dynamic team. Knowledge in Bioimaging, Signal
    Processing, Biomechanics and/or Bioengineering is an advantage. The
    position is available upon January 2011 or upon mutual agreement.
    Salaries are highly competitive and are in line with the guidelines of
    ETH Zurich.

    A curriculum vitae, a list of two references and all university classes
    attended (including grades) as well as a one-page statement of your
    background and research interest should be sent to (preferably by email):

    Dr. Philipp Schneider
    Institute for Biomechanics
    ETH Zurich, Wolfgang-Pauli-Strasse 10, 8093 Zurich, Switzerland
    Email:, Web: