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PhD position: Study of mechanical stimuli in bone tissue engineering

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  • PhD position: Study of mechanical stimuli in bone tissue engineering

    We have 2 vacancies for bright, enthusiastic, self-motivated PhD students to join the Mechanobiology group ( in the Department of Mechanical Engineering at the University of Sheffield. The research group has an extensive experience in the development of computer simulations and bioreactor stimulations to better understand the interaction between biomaterials, cell biology and mechanical stimuli.

    Tissue engineering and regenerative medicine which aim to repair, regenerate or create damaged tissues offer significant promises clinically. Rapid advances in technology have created the realistic possibility of personalized medicine. In 2000, Time magazine listed tissue engineering as one of the ‘hottest 10 career choices’. It is a field that can truly impact health care and personalized medicine. Novel development in fabrication technique and biomaterials are bringing closer to reality the possibility of creating personalized bone implant. Bone holds remarkable mechanical properties due to its structural organization. However, engineering bone constructs with sufficient tissue quality and that replicates the complex zonal organization of cells and extracellular matrix in native bone represents a significant challenge. This project aims to investigate novel approaches to study cell differentiation both mechanically and chemically. It also intends to provide control over the location of the cells within the constructs using methods and equipment in our lab from human mesenchymal stem cells (MSCs). Imaging techniques derived from micro-computed tomography will also be developed to monitor cell response in situ.

    The successful candidate should have or be expected to obtain a 1st class or a good 2.1 degree in mechanical engineering, bioengineering, physics, or a related discipline, and should be enthusiastic about fundamental research. Previous experience in in vitro cell culture, working with porous 3D scaffolds, biochemical assays techniques (e.g PCR, DNA/ECM protein quantification, histo-/immunohisto-chemistry techniques and imaging are highly advantageous.

    This studentship funded by the European Research Council is available immediately. A tax-free stipend at £15,000 per annum is available for three years, plus tuition fees at the UK/EU rate. Applicants from outside UK/EU will only be considered if they are ready to pay the difference between student fees at home rate and overseas rate themselves.
    For an informal discussion on the project please email Prof. Damien Lacroix:

    To apply, please use our standard on-line PhD application form ( together with your cv and 2 references, and indicate on your form that you are replying to this advert.
    Deadline: 30 April 2012