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Research Associate
Development of computational models of bone formation and resorption to predict changes in bone in preclinical intervention studies
University of Sheffield -Faculty of Engineering, Mechanical Engineering
Job Reference Number: UOS006291
Contract Type: Fixed-term with a start date of 1/7/2013 and an end date of 30/6/2015.
Location: INSIGNEO Institute for in silico medicine
Salary: Grade 7 -£28,685-29,249 per annum.
Closing Date: 17 May 2013
Summary:
The INSIGNEO Institute for in silico Medicine is an initiative between the Faculty of Engineering and the Faculty of Medicine at the University of Sheffield and the Sheffield Teaching Hospitals Foundation Trust. INSIGNEO intends to realise the scientific ambition behind the Virtual Physiological Human, producing a transformational impact on healthcare. While recently established, INSIGNEO is already considered one of worldwide-leading institutions in the area of in silico medicine research. For more information on INSIGNEO please see our web pages: http://www.insigneo.org/.
One of the strategic objectives of INSIGNEO is to supplement animal experimentation with in silico technologies in order to refine, reduce and eventually partially replace animal testing. In this 24 months' project, funded by the National Centre for Reduction, Refinement and Replacement of animals in research (NC3Rs), we plan to develop a protocol that uses non-invasive microCT-based bone tissue morphometry to follow-up longitudinally the effect of various interventions over time, micro-finite element modelling to correlate such changes with the biomechanical environment, and bone remodelling prediction algorithms to attempt an in silico replication of the observed response, so as to eventually replace part of the animal experimentation.
The ideal candidate for this post would hold a PhD (or equivalent experience) in Engineering, Physics, or related disciplines, with a PhD thesis on musculoskeletal computational biomechanics, a good knowledge of musculoskeletal anatomy and physiology, in depth knowledge of finite element analysis, a good understanding of medical imaging methods and some programming skills with Matlab and C/C++ language. Under the supervision of Prof Viceconti, internationally recognised expert in multiscale modelling of the musculoskeletal system, and in collaboration with Dr Ilaria Bellantuono, specialist in bone biology, the post-holder will develop computational models of bone formation and resorption to predict changes in bone in preclinical intervention studies.
To apply:
Development of computational models of bone formation and resorption to predict changes in bone in preclinical intervention studies
University of Sheffield -Faculty of Engineering, Mechanical Engineering
Job Reference Number: UOS006291
Contract Type: Fixed-term with a start date of 1/7/2013 and an end date of 30/6/2015.
Location: INSIGNEO Institute for in silico medicine
Salary: Grade 7 -£28,685-29,249 per annum.
Closing Date: 17 May 2013
Summary:
The INSIGNEO Institute for in silico Medicine is an initiative between the Faculty of Engineering and the Faculty of Medicine at the University of Sheffield and the Sheffield Teaching Hospitals Foundation Trust. INSIGNEO intends to realise the scientific ambition behind the Virtual Physiological Human, producing a transformational impact on healthcare. While recently established, INSIGNEO is already considered one of worldwide-leading institutions in the area of in silico medicine research. For more information on INSIGNEO please see our web pages: http://www.insigneo.org/.
One of the strategic objectives of INSIGNEO is to supplement animal experimentation with in silico technologies in order to refine, reduce and eventually partially replace animal testing. In this 24 months' project, funded by the National Centre for Reduction, Refinement and Replacement of animals in research (NC3Rs), we plan to develop a protocol that uses non-invasive microCT-based bone tissue morphometry to follow-up longitudinally the effect of various interventions over time, micro-finite element modelling to correlate such changes with the biomechanical environment, and bone remodelling prediction algorithms to attempt an in silico replication of the observed response, so as to eventually replace part of the animal experimentation.
The ideal candidate for this post would hold a PhD (or equivalent experience) in Engineering, Physics, or related disciplines, with a PhD thesis on musculoskeletal computational biomechanics, a good knowledge of musculoskeletal anatomy and physiology, in depth knowledge of finite element analysis, a good understanding of medical imaging methods and some programming skills with Matlab and C/C++ language. Under the supervision of Prof Viceconti, internationally recognised expert in multiscale modelling of the musculoskeletal system, and in collaboration with Dr Ilaria Bellantuono, specialist in bone biology, the post-holder will develop computational models of bone formation and resorption to predict changes in bone in preclinical intervention studies.
To apply:
