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PhD: Design & Development of New Ligament & Tendon Implants - Manchester, UK

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  • PhD: Design & Development of New Ligament & Tendon Implants - Manchester, UK

    PhD studentship: Design & Development of New Ligament & Tendon Implants
    Manchester Metropolitan University, UK

    Many current tendon/ligament replacements utilise woven structures, inadequately matching the biological environments and/or tissues they aim to substitute.
    We seek to use an alternative fabrication technique (electrospinning) and to design these fibrous structures to enhance cell repair and growth mechanisms, producing a bioengineered construct optimised for location and placement.

    Project Aims and Objectives:
    Damaged or diseased ligaments and tendons have a major impact upon a person’s mobility and lifestyle. The problem is becoming increasingly common due to sports injuries, obesity and an ageing population. Current treatments include reconstruction with an autograft or allograft rather than primary repair; however, these reconstructions contain inherent problems such as reduced Young’s modulus associated with scar tissue, secondary injury or tearing after surgery, or additional complications. A large number of the currently available tendon and ligament replacements are produced using woven structures, and have been shown to be inadequate matches for the biological environments and/or structures they seek to substitute. This project aims to understand the mechanical design requirements of the tendon/ligament and to investigate novel tissue engineering manufacturing methods to produce implants.

    Project Aim: to develop electrospun artificial ligaments/tendons based on functional biomechanical and cell regeneration requirements.

    The project will involve reviewing the literature, developing a product design specification, engineering analysis techniques, biomechanics and tissue engineering (including cell culture).

    Candidate Requirements:
    Essential:
    A good (2i or First Class) undergraduate degree in Engineering, Biomedical Sciences/Bioengineering, Physics or similar (BEng, MEng, BSc) (or equivalent industrial experience)
    Good written and verbal English language skills (IELTS 6.5 or equivalent if English is not first language)
    Ability to work in a team and conduct tasks independently
    Good level Mathematics ability
    An appreciation for the field of biomedical engineering
    Desirable Skills:
    Postgraduate Masters level qualification
    Experience of mathematical stress modelling or finite element analysis and/or programming skills
    Tissue engineering experience (cell culture, sample analysis)
    Understanding of electrospinning as a materials fabrication technique
    Understanding of composite material mechanics
    Experience of mechanical testing

    Student Eligibility
    Fully funded PhD studentships at the Manchester Metropolitan University are only available to home and EU students.

    Informal enquiries can be made to Dr. Kirstie Andrews: email K.Andrews@mmu.ac.uk; Dr. Glen Cooper: email g.cooper@mmu.ac.uk or Prof. Neil Reeves: email N.Reeves@mmu.ac.uk.

    Closing date for applications: 13th April, 2014.
    To Apply please visit:
    http://www2.mmu.ac.uk/research/stude...d-engineering/
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