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TITLE OF POST: Post Doctoral Researcher in Bone Mechanobiology
LOCATION: University of Limerick / Trinity College Dublin
SALARY SCALE: €37,750 - €46,255 p.a. (maximum starting salary €42,394 p.a.)
QUALIFICATIONS:
OVERALL PURPOSE OF THE JOB:
The primary purpose of this position is to conduct experimental studies of cellular mechanosensing in bone as it relates to stem cell homing and differentiation in-vivo, to publish this research in international academic journals and contribute to future research proposals on the area of bone mechanosensing.
DESCRIPTION:
Osteoporosis arises when mesenchymal stem cells (MSC) fail to produce sufficient numbers of bone forming osteoblasts. A key regulator of MSC behaviour is physical loading, yet the mechanisms by which MSCs sense and respond to changes in their mechanical environment are virtually unknown. Primary cilia are nearly ubiquitous ‘antennae-like’ cellular organelles that have very recently emerged as extracellular sensors and thus, are strong candidates to play an important role in regulating MSC responses in bone. Therefore, the objective of this research project is to determine the role of the understudied primary cilium and associated molecular components in the osteogenic differentiation and recruitment of human MSCs in loading-induced bone adaptation. This work has implications for both bone tissue engineering and therapeutic development for diseases such as osteoporosis.
The successful applicant will work within a multidisciplinary environment in the MSSI and CABER in the University of Limerick and the Trinity Centre for Bioengineering, Trinity College Dublin. The position is funded by an ERC Starting Grant.
Essential:
Desirable:
More details and application forms can be found at https://psi.ul.ie/pls/corehrrecruit/...m.display_form.
Applications MUST be completed ONLINE before 12 NOON on August 11th.
Informal enquiries regarding the post may be directed to:
Dr. David Hoey
Dept of Mechanical, Aeronautical & Biomedical Engineering
University of Limerick
Email: david.hoey@ul.ie
LOCATION: University of Limerick / Trinity College Dublin
SALARY SCALE: €37,750 - €46,255 p.a. (maximum starting salary €42,394 p.a.)
QUALIFICATIONS:
- BEng/BSc in Biomedical/Mechanical Engineering or Cell Biology/Biochemistry
- PhD (completed or at final stages of completion) in Biomedical Engineering or PhD with substantial research of relevance to the subject of the position.
OVERALL PURPOSE OF THE JOB:
The primary purpose of this position is to conduct experimental studies of cellular mechanosensing in bone as it relates to stem cell homing and differentiation in-vivo, to publish this research in international academic journals and contribute to future research proposals on the area of bone mechanosensing.
DESCRIPTION:
Osteoporosis arises when mesenchymal stem cells (MSC) fail to produce sufficient numbers of bone forming osteoblasts. A key regulator of MSC behaviour is physical loading, yet the mechanisms by which MSCs sense and respond to changes in their mechanical environment are virtually unknown. Primary cilia are nearly ubiquitous ‘antennae-like’ cellular organelles that have very recently emerged as extracellular sensors and thus, are strong candidates to play an important role in regulating MSC responses in bone. Therefore, the objective of this research project is to determine the role of the understudied primary cilium and associated molecular components in the osteogenic differentiation and recruitment of human MSCs in loading-induced bone adaptation. This work has implications for both bone tissue engineering and therapeutic development for diseases such as osteoporosis.
The successful applicant will work within a multidisciplinary environment in the MSSI and CABER in the University of Limerick and the Trinity Centre for Bioengineering, Trinity College Dublin. The position is funded by an ERC Starting Grant.
Essential:
- BEng/BSc in Biomedical/Mechanical Engineering or Cell Biology/Biochemistry
- PhD (or be about to complete a PhD) in Biomedical Engineering or PhD with substantial research of relevance to the subject of the position.
Desirable:
- Experience in small animal models, ulna-loading, histology, stem cell and primary cilia biology.
- Strong publication record.
- Demonstrated ability to mentor PhD students.
More details and application forms can be found at https://psi.ul.ie/pls/corehrrecruit/...m.display_form.
Applications MUST be completed ONLINE before 12 NOON on August 11th.
Informal enquiries regarding the post may be directed to:
Dr. David Hoey
Dept of Mechanical, Aeronautical & Biomedical Engineering
University of Limerick
Email: david.hoey@ul.ie