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Applications are invited for an interdisciplinary Post-Doctoral Research Fellowship at the Institut de Biomécanique Humaine Georges Charpak at ENSAM-ParisTech / Centre des matériaux de Mines-ParisTech (Paris, France) to work in the field of Computational Modelling, and more specifically on the Modelling the osseointegration of hydrogel implants.
In recent works, our team at Mines-ParisTech has shown that materials made from biocompatible synthetic hydrogel closely reproduce the water content and tensile behavior of human ligaments (Bach et al. J.Biomech. 46, 2013). Ensuring the proper osseointegration of these implants and in particular their strong anchoring to bone tissue is a major challenge to take in order to bring this technology to the clinics. This project aims at addressing this question by using a bio-mechanical modeling approach coupling cell activity at the microscopic scale and mechanical state at the meso- and macroscopic scales. The main objective is to develop new quantitative and predictive models that will provide guides for the design of these implants. Besides its interest for artificial ligaments, these tools and approaches have numerous perspectives in terms of applications and a strong potential in the field of medical device is anticipated. The post-doctoral researcher will join a very multidisciplinary team composed of experts in musculoskeletal biomechanics and cell biomechanics, physicists and engineers experts in the design of implantable materials. Moreover, the model validation will benefit from the results of a recent in vivo study in the small animal, obtained in collaboration with a team of biologists and clinicians.
Collaboration : This post-doctoral position is funded by the Fédération Francilienne de Mécanique and will be jointly supervised by the teams of the Institut de Biomécanique Humaine Georges Charpak de l’ENSAM Paris (R. Allena, P.-Y. Rohan) and of the Centre des matériaux de Mines-ParisTech (L. Corté). It will mostly take place at the Institut de Biomécanique Humaine Georges Charpak.
Profile : mechanical engineer, biomechanical engineer and/or biophysicist. Previous experience in numerical modeling is required and knowledge of COMSOL software will be appreciated.
Starting date : ideally between September and November 2016.
Duration : 12 months
Application : Applications should gather a covering letter including a brief statement of research interests, CV and the details of two references. Both applications and informal enquiries may be addressed to: rachele.allena@ensam.eu, laurent.corte@mines-paristech.fr and pierre-yves.rohan@ensam.eu
In recent works, our team at Mines-ParisTech has shown that materials made from biocompatible synthetic hydrogel closely reproduce the water content and tensile behavior of human ligaments (Bach et al. J.Biomech. 46, 2013). Ensuring the proper osseointegration of these implants and in particular their strong anchoring to bone tissue is a major challenge to take in order to bring this technology to the clinics. This project aims at addressing this question by using a bio-mechanical modeling approach coupling cell activity at the microscopic scale and mechanical state at the meso- and macroscopic scales. The main objective is to develop new quantitative and predictive models that will provide guides for the design of these implants. Besides its interest for artificial ligaments, these tools and approaches have numerous perspectives in terms of applications and a strong potential in the field of medical device is anticipated. The post-doctoral researcher will join a very multidisciplinary team composed of experts in musculoskeletal biomechanics and cell biomechanics, physicists and engineers experts in the design of implantable materials. Moreover, the model validation will benefit from the results of a recent in vivo study in the small animal, obtained in collaboration with a team of biologists and clinicians.
Collaboration : This post-doctoral position is funded by the Fédération Francilienne de Mécanique and will be jointly supervised by the teams of the Institut de Biomécanique Humaine Georges Charpak de l’ENSAM Paris (R. Allena, P.-Y. Rohan) and of the Centre des matériaux de Mines-ParisTech (L. Corté). It will mostly take place at the Institut de Biomécanique Humaine Georges Charpak.
Profile : mechanical engineer, biomechanical engineer and/or biophysicist. Previous experience in numerical modeling is required and knowledge of COMSOL software will be appreciated.
Starting date : ideally between September and November 2016.
Duration : 12 months
Application : Applications should gather a covering letter including a brief statement of research interests, CV and the details of two references. Both applications and informal enquiries may be addressed to: rachele.allena@ensam.eu, laurent.corte@mines-paristech.fr and pierre-yves.rohan@ensam.eu