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MultiSim is a five-year programme that aims to create a new modelling framework for thehuman musculoskeletal system. The £6.7M Frontier Engineering grant from the Engineering andPhysical Sciences Research Council (EPSRC) – awarded to the world leading and innovativeInsigneo Institute – will improve treatments for diseases of the musculoskeletal system.
The post holder will work the modelling and simulation of cell mechanotransduction osteocytenetwork to control osteoblast and osteoclast activation in bone under physiological andpathological conditions. A modelling approach will be taken to simulate the influence of themechanical stimuli within the osteocyte network on the activation of ion and molecular pathwaysthat control calcium release. The models will be integrated into a hypermodelling framework thatconsists of several sub-models at various scales (cell, tissue, organ, body) so that an overallmusculoskeletal model can be generated.
Applicants should hold a PhD in the Life Sciences, Engineering, Physics, or related disciplines andbe familiar with modelling of cells and the musculoskeletal system.
For more information, please visit:
Job Code: UOS013997
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Closing date: 5th July
Interview date: 18th July
This post is fixed-term for 2 years.
For informal enquiries about this job and department, contact: Professor Tim Skerry on T.Skerry@sheffield.ac.uk or on +44 114 271 2414 or Professor Damien Lacroix on D.Lacroix@sheffield.ac.uk or on +44 114 222 0156.
_________________________________________
Prof. Damien Lacroix
Chair in Biomedical Engineering
University of Sheffield
INSIGNEO Institute for in silico Medicine
Department of Mechanical Engineering
Pam Liversidge Building - Room F32
Sir Frederick Mappin Building
Mappin Street
Sheffield
S1 3JD
UK
Phone: +44 (0)114 2220156
Email: D.Lacroix@sheffield.ac.uk
http://www.mechanobiology.co.uk
http://multisim-insigneo.org
_________________________________________
The post holder will work the modelling and simulation of cell mechanotransduction osteocytenetwork to control osteoblast and osteoclast activation in bone under physiological andpathological conditions. A modelling approach will be taken to simulate the influence of themechanical stimuli within the osteocyte network on the activation of ion and molecular pathwaysthat control calcium release. The models will be integrated into a hypermodelling framework thatconsists of several sub-models at various scales (cell, tissue, organ, body) so that an overallmusculoskeletal model can be generated.
Applicants should hold a PhD in the Life Sciences, Engineering, Physics, or related disciplines andbe familiar with modelling of cells and the musculoskeletal system.
For more information, please visit:
Job Code: UOS013997
Closing date: 5th July
Interview date: 18th July
This post is fixed-term for 2 years.
For informal enquiries about this job and department, contact: Professor Tim Skerry on T.Skerry@sheffield.ac.uk or on +44 114 271 2414 or Professor Damien Lacroix on D.Lacroix@sheffield.ac.uk or on +44 114 222 0156.
_________________________________________
Prof. Damien Lacroix
Chair in Biomedical Engineering
University of Sheffield
INSIGNEO Institute for in silico Medicine
Department of Mechanical Engineering
Pam Liversidge Building - Room F32
Sir Frederick Mappin Building
Mappin Street
Sheffield
S1 3JD
UK
Phone: +44 (0)114 2220156
Email: D.Lacroix@sheffield.ac.uk
http://www.mechanobiology.co.uk
http://multisim-insigneo.org
_________________________________________