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Joint Melbourne-Birmingham PhD - single ventricle heart function in children

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  • Joint Melbourne-Birmingham PhD - single ventricle heart function in children

    Further details can be found at:

    In collaboration with clinical researchers at the Murdoch Children’s Research Institute (MCRI), and biomechanics and multi-scale computational modelling experts at the University of Birmingham and University of Melbourne, this project will investigate the efficacy of Fontan circulation procedures in providing viable long term heart function to children affected by this congenital disease. Students working on this project will:
    • work closely with clinicians at the MCRI to collect magnetic resonance imaging (MRI) data of heart structure and function of children with a Fontan circulation. In particular, they will measure changes in cardiac output before and after exercise.
    • use the MRI data to create in-silico 3D computer models of the hearts to develop computer simulations of the heart beat that accurately represent the electrical and mechanical function measured in the experimental data;
    • perform ex-vivo measurements of cardiac tissue electrical and mechanical properties sourced from animal models that are commonly used as surrogates for children’s hearts.
    • use the experimental data and the structurally and functionally accurate models of the heart to examine the patterns of electrical activity, strain and stress that are introduced after a Fontan procedure.

    Funding Notes
    A fully-funded studentship, which includes tax-free Doctoral Stipend of £14,553 per annum, is available for Home/EU and Overseas students on this Joint PhD programme between the University of Birmingham and the University of Melbourne for October 2018 start. For engineering students who are to be hosted by the University of Melbourne, the scholarship rate will be $AUD30,000 p.a. and will include provision for a return trip to Birmingham.

    For further information contact either:
    Dr Daniel Espino:
    Profile for Dr Daniel M Espino, Mechanical Engineering, University of Birmingham.

    Dr Vijay Rajagopal: