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6-mo internships x 2 for MSc students (neuromuscular respiratory physiology / ultrasound imaging / PET MRI) - UMRS 1158 Paris, France
(Only for students enrolled in a master's program during the current 2022-2023 academic year; feel free to contact me if you are looking for an internship next academic year 2023-2024)
6-month internships for MSc students
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Multimodal assessment of diaphragm contractility
UMR-S 1158, Paris
Locations: UMR-S 1158 Hôpital Universitaire La Pitié-Salpêtrière, 47-83 boulevard de l'Hôpital, 75013, Paris, France with collaborators at BioMaps (Orsay) and the Institute of Myology (Paris)
Starting date: January 2023.
Project summary: We are aiming to combine non-volitional assessment of diaphragm contractility relying on phrenic magnetic stimulation with ultrafast ultrasound imaging (1, 2) in patients with diaphragm dysfunction.
Profile: The candidate must be an MSc student in a relevant discipline(s) (e.g. biomechanics, respiratory physiology, human movement sciences, and rehabilitation sciences). Experience with relevant laboratory techniques is desirable but a strong willingness to learn and an inquisitive attitude is essential. Experience with image analysis/signal processing and computer-programing skills (Matlab, R) are also desirable. Although not mandatory, French speaking is desirable, as the candidate will work with healthy volunteers and patients.
Keywords: Ultrasound imaging, skeletal muscle physiology, respiratory physiology, biomarkers, diaphragm
Contact: Interested applicants should email directly Damien Bachasson (d.bachasson@institut-myologie.org) with a cover letter and a detailed CV. Applications in French and English will be reviewed.
References:
1. D. Bachasson, M. Dres, M. Nierat, J. Doorduin, J. Gennisson, J. Hogrel, T. Similowski, in 2018 IEEE International Ultrasonics Symposium (IUS). (2018), pp. 1-4.
2. T. Poulard, M. Dres, M. C. Nierat, I. Rivals, J. Y. Hogrel, T. Similowski, J. L. Gennisson, D. Bachasson, Ultrafast ultrasound coupled with cervical magnetic stimulation for non-invasive and non-volitional assessment of diaphragm contractility. J. Physiol. n/a, (2020); published online EpubSep 30 (10.1113/JP280457).
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Multiparametric ultrasound imaging of the respiratory muscles
UMR-S 1158, Paris
Locations: UMR-S 1158 Hôpital Universitaire La Pitié-Salpêtrière, 47-83 boulevard de l'Hôpital, 75013, Paris, France with collaborators at BioMaps (Orsay), Institute of Myology (Paris), and eScopics (Saint-Cannat).
Starting date: January 2023.
Funded by: Agence Nationale de la Recherche (ULTRADIAPH project).
Project partners: UMR-S 1158, BioMaps Laboratory, Institute of Myology, eScopics.
Project summary: The overarching goal of the ULTRADIAPH project is to develop innovative ultrasound-based biomarkers for respiratory muscle structure and function. To fulfill this goal, we are aiming to develop an ultraportable solution relying on ultrafast ultrasound providing new tissue-level characterization and reducing operator-dependency of current methods. We intend to use this new tool to improve knowledge regarding respiratory muscle dysfunction induced by mechanical ventilation within the intensive care unit with the ultimate goal to improve the management of these patients. Within this internship, the MSc student will be involved in experiments in healthy volunteers and patients under mechanical ventilation within the intensive care unit. She/he will also be involved in the development of the device software and the validation of the developed tools.
Profile: The candidate must be an MSc student in a relevant discipline(s) (e.g. biomechanics, respiratory physiology, human movement sciences, rehabilitation sciences). Experience with relevant laboratory techniques is desirable but a strong willingness to learn and an inquisitive attitude is essential. Experience with image analysis/signal processing and computer-programing skills (Matlab, R) are also desirable. Although not mandatory, French speaking is desirable, as the candidate will work with healthy volunteers and patients.
Keywords: Ultrasound imaging, skeletal muscle physiology, respiratory physiology, biomarkers, diaphragm, mechanical ventilation, intensive care unit
Contact: Interested applicants should email directly Damien Bachasson (d.bachasson@institut-myologie.org) with a cover letter and a detailed CV. Applications in French and English will be reviewed.
References:
1. D. Bachasson, M. Dres, M. C. Nierat, J. L. Gennisson, J. Y. Hogrel, J. Doorduin, T. Similowski, Diaphragm shear modulus reflects transdiaphragmatic pressure during isovolumetric inspiratory efforts and ventilation against inspiratory loading. J Appl Physiol (1985) 126, 699-707 (2019); published online EpubMar 1 (10.1152/japplphysiol.01060.2018).
2. Q. Fosse, T. Poulard, M. C. Nierat, S. Virolle, E. Morawiec, J. Y. Hogrel, T. Similowski, A. Demoule, J. L. Gennisson, D. Bachasson, M. Dres, Ultrasound shear wave elastography for assessing diaphragm function in mechanically ventilated patients: a breath-by-breath analysis. Crit. Care 24, 669 (2020); published online EpubNov 27 (10.1186/s13054-020-03338-y).
3. T. Poulard, M. Dres, M. C. Nierat, I. Rivals, J. Y. Hogrel, T. Similowski, J. L. Gennisson, D. Bachasson, Ultrafast ultrasound coupled with cervical magnetic stimulation for non-invasive and non-volitional assessment of diaphragm contractility. J. Physiol. 598, 5627-5638 (2020); published online EpubDec (10.1113/JP280457).
4. T. Poulard, D. Bachasson, Q. Fosse, M. C. Nierat, J. Y. Hogrel, A. Demoule, J. L. Gennisson, M. Dres, Poor Correlation between Diaphragm Thickening Fraction and Transdiaphragmatic Pressure in Mechanically Ventilated Patients and Healthy Subjects. Anesthesiology 136, 162-175 (2022); published online EpubJan 1 (10.1097/ALN.0000000000004042).
6-month internships for MSc students
----
Multimodal assessment of diaphragm contractility
UMR-S 1158, Paris
Locations: UMR-S 1158 Hôpital Universitaire La Pitié-Salpêtrière, 47-83 boulevard de l'Hôpital, 75013, Paris, France with collaborators at BioMaps (Orsay) and the Institute of Myology (Paris)
Starting date: January 2023.
Project summary: We are aiming to combine non-volitional assessment of diaphragm contractility relying on phrenic magnetic stimulation with ultrafast ultrasound imaging (1, 2) in patients with diaphragm dysfunction.
Profile: The candidate must be an MSc student in a relevant discipline(s) (e.g. biomechanics, respiratory physiology, human movement sciences, and rehabilitation sciences). Experience with relevant laboratory techniques is desirable but a strong willingness to learn and an inquisitive attitude is essential. Experience with image analysis/signal processing and computer-programing skills (Matlab, R) are also desirable. Although not mandatory, French speaking is desirable, as the candidate will work with healthy volunteers and patients.
Keywords: Ultrasound imaging, skeletal muscle physiology, respiratory physiology, biomarkers, diaphragm
Contact: Interested applicants should email directly Damien Bachasson (d.bachasson@institut-myologie.org) with a cover letter and a detailed CV. Applications in French and English will be reviewed.
References:
1. D. Bachasson, M. Dres, M. Nierat, J. Doorduin, J. Gennisson, J. Hogrel, T. Similowski, in 2018 IEEE International Ultrasonics Symposium (IUS). (2018), pp. 1-4.
2. T. Poulard, M. Dres, M. C. Nierat, I. Rivals, J. Y. Hogrel, T. Similowski, J. L. Gennisson, D. Bachasson, Ultrafast ultrasound coupled with cervical magnetic stimulation for non-invasive and non-volitional assessment of diaphragm contractility. J. Physiol. n/a, (2020); published online EpubSep 30 (10.1113/JP280457).
---
Multiparametric ultrasound imaging of the respiratory muscles
UMR-S 1158, Paris
Locations: UMR-S 1158 Hôpital Universitaire La Pitié-Salpêtrière, 47-83 boulevard de l'Hôpital, 75013, Paris, France with collaborators at BioMaps (Orsay), Institute of Myology (Paris), and eScopics (Saint-Cannat).
Starting date: January 2023.
Funded by: Agence Nationale de la Recherche (ULTRADIAPH project).
Project partners: UMR-S 1158, BioMaps Laboratory, Institute of Myology, eScopics.
Project summary: The overarching goal of the ULTRADIAPH project is to develop innovative ultrasound-based biomarkers for respiratory muscle structure and function. To fulfill this goal, we are aiming to develop an ultraportable solution relying on ultrafast ultrasound providing new tissue-level characterization and reducing operator-dependency of current methods. We intend to use this new tool to improve knowledge regarding respiratory muscle dysfunction induced by mechanical ventilation within the intensive care unit with the ultimate goal to improve the management of these patients. Within this internship, the MSc student will be involved in experiments in healthy volunteers and patients under mechanical ventilation within the intensive care unit. She/he will also be involved in the development of the device software and the validation of the developed tools.
Profile: The candidate must be an MSc student in a relevant discipline(s) (e.g. biomechanics, respiratory physiology, human movement sciences, rehabilitation sciences). Experience with relevant laboratory techniques is desirable but a strong willingness to learn and an inquisitive attitude is essential. Experience with image analysis/signal processing and computer-programing skills (Matlab, R) are also desirable. Although not mandatory, French speaking is desirable, as the candidate will work with healthy volunteers and patients.
Keywords: Ultrasound imaging, skeletal muscle physiology, respiratory physiology, biomarkers, diaphragm, mechanical ventilation, intensive care unit
Contact: Interested applicants should email directly Damien Bachasson (d.bachasson@institut-myologie.org) with a cover letter and a detailed CV. Applications in French and English will be reviewed.
References:
1. D. Bachasson, M. Dres, M. C. Nierat, J. L. Gennisson, J. Y. Hogrel, J. Doorduin, T. Similowski, Diaphragm shear modulus reflects transdiaphragmatic pressure during isovolumetric inspiratory efforts and ventilation against inspiratory loading. J Appl Physiol (1985) 126, 699-707 (2019); published online EpubMar 1 (10.1152/japplphysiol.01060.2018).
2. Q. Fosse, T. Poulard, M. C. Nierat, S. Virolle, E. Morawiec, J. Y. Hogrel, T. Similowski, A. Demoule, J. L. Gennisson, D. Bachasson, M. Dres, Ultrasound shear wave elastography for assessing diaphragm function in mechanically ventilated patients: a breath-by-breath analysis. Crit. Care 24, 669 (2020); published online EpubNov 27 (10.1186/s13054-020-03338-y).
3. T. Poulard, M. Dres, M. C. Nierat, I. Rivals, J. Y. Hogrel, T. Similowski, J. L. Gennisson, D. Bachasson, Ultrafast ultrasound coupled with cervical magnetic stimulation for non-invasive and non-volitional assessment of diaphragm contractility. J. Physiol. 598, 5627-5638 (2020); published online EpubDec (10.1113/JP280457).
4. T. Poulard, D. Bachasson, Q. Fosse, M. C. Nierat, J. Y. Hogrel, A. Demoule, J. L. Gennisson, M. Dres, Poor Correlation between Diaphragm Thickening Fraction and Transdiaphragmatic Pressure in Mechanically Ventilated Patients and Healthy Subjects. Anesthesiology 136, 162-175 (2022); published online EpubJan 1 (10.1097/ALN.0000000000004042).