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PhD Candiate Opening: Characterization of Structural Remodelling in Tissue-Engineered Human Skeletal Muscles During Multi-Week Training (U. Twente, NL)

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  • PhD Candiate Opening: Characterization of Structural Remodelling in Tissue-Engineered Human Skeletal Muscles During Multi-Week Training (U. Twente, NL)

    Are you interested in laying down the basis for developing breakthrough regenerative technologies for restoring movement following neuromuscular injuries? Are you passionate about investigating how skeletal muscles remodel their biological structure when exposed to electrical and mechanical stimuli over multiple weeks? Are you interested in doing so by combining advanced in vitrotechniques for tissue-engineering muscles from human induced pluripotent stem cells together with computational modelling techniques?

    The Neuro-Mechanical Modeling and Engineering Lab ( is seeking for an outstanding PhD candidate fellow to work within our new Project ROBOREACTOR funded by the prestigious European Research Council (Consolidator Grant). You will join an international team working on a novel and ambitious project at the frontiers of muscle neurophysiology, muscle tissue regeneration and regenerative robotics (

    The opening:
    We are seeking for a motivated person that understands the physiology of skeletal muscles and isenthusiastic about working in cell culture labs for creating tissue-engineered skeletal muscles in vitro from human induced pluripotent stem cells (hiPSCs).
    We are also looking for someone who will design four-week eccentric training protocols for pacing the tissue-engineered muscles and analyze how these tissues remodel their morphology over time e.g., genesis of sarcomeres (i.e., in parallel and in series), phenotype (i.e., fiber type transition between fast and slow types), and changes in tissue force-generating capacity.
    We are also looking for somebody who can learn to use computational modelling to predict how tissue-engineered muscles remodel during the 4-week eccentric training.

    Your tasks will be:
    • Design and conduct 4-week in vitro experiments on tissue-engineered skeletal muscle to mimic eccentric muscle training, incorporating both electrical and mechanical pacing.
    • To characterize structural remodelling in the tissue-engineered muscles. This implies the ability of characterizing changes in tissue force-generating capacity, morphology, phenotype and myotrophic factors.
    • Use the gathered data to establish computational models of muscle structural remodelling.

    Your work will be facilitated by in-house expertise and mentorship. You will collaborate with top-scientists on aspects including muscle-on-a-chip and statistical modelling, giving large opportunity to perform impactful research!

    Information and application

    Apply by August 18th, 2024 from this link:

    Applications must include the following documents:
    • A video (2-minute max) describing your scientific interests and why you want to apply for this position.
    • A cover letter (1-page max) specifying how your experience and skills match the position as well as summarizing work in your masters.
    • A CV including English proficiency level, nationality, visa requirements, date of birth, experience overview, and publication list.
    • Contact information for at least two academic references. A support letter will be requested only if your application is considered.

    The first interview will take place in the week of September the 2nd. Start of the contract is expected as soon as possible and no later than December 2024. For questions, please contact Prof. Massimo Sartori, mail: Please, only apply via the web platform and not via email.

    Massimo Sartori
    Full Professor and Head of Chair, Neuromuscular Robotics

    Lab Head, Neuromechanical Modeling and Engineering Lab

    University of Twente, TechMed Centre, Robotics Centre
    Faculty of Engineering Technology
    Department of Biomechanical Engineering
    7500 AE, The Netherlands


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